1. 12 juin 2016 - 1 ADVANCE IN DERMATO - COSMETOLOGY Auriderm XO Vitamin K oxide Metabolite Patented

2. 12 juin 2016 - 2 ADVANCE IN DERMATO - COSMETOLOGY Elson 1 (clinical trial) observed that vitamin K influenced the absorption of bruising produced by the injection of autologous whole blood intradermally and subcutaneously. Topical vitamin K is now emerging as potential factor in cutaneous physio-pharmacology. Topical Vitamin K Melvin l. Elson, M.D. is a practicing dermatologist; medical director of the dermatology center Inc. Nashville,Tenn. and President & Chief Executive Officer of Cosmeceutical Research

3. 12 juin 2016 - 3 ADVANCE IN DERMATO - COSMETOLOGY 1995 Melvin Elson, MD, published his clinical trial in Cosmetic Dermatology Journal for the use of vitamin K in the treatment of actinic and traumatic purpura. Topical Vitamin K Topical Phytonadione (Vitamin K) in the treatment of Actinic and Traumatic Purpura, Vol. 8 No. 12 December - Cosmetic Dermatology

4. 12 juin 2016 - 4 ADVANCE IN DERMATO - COSMETOLOGY Trial results prove that topical vitamin K has an influence on the disappearance of extra vascular blood decreasing the incidence of bruising when compared to its base. In addition, there is a number of clinical situations in which there is increased bleeding diathesis into skin. Steroidal therapy, both systemic and topical The use of salicylates Topical Vitamin K Topical Phytonadione (Vitamin K) in the treatment of Actinic and Traumatic Purpura, Vol. 8 No. 12 December - Cosmetic Dermatology

5. 12 juin 2016 - 5 ADVANCE IN DERMATO - COSMETOLOGY Open evaluation studies revealed more rapid resolution of purpura than expected in normal circumstances as well as prevention of purpura which normally occur with surgical and cosmetic procedures including blepharoplasty, rhytidictomy, collagen injection and facial liposuction. The whole blood created bruising cleared in 5 to 8 days with the use of vitamin K and it took 11 to 13 days for total resolution in placebo sites. Topical Phytonadione (Vitamin K) in the Treatment of Actinic and Traumatic Purpura, Vol. 8 No. 12 December - Cosmetic Dermatology Topical Vitamin K

6. 12 juin 2016 - 6 ADVANCE IN DERMATO - COSMETOLOGY Purpura, an expected consequence of pulsed dye laser treatment, is usually quite an annoyance to patients. Vitamin K & Laser induced purpura Wendy.W. Lou,MD,Adelle T. Quintana,MD,Roy G. Geronemus,MD & Melanie C. Grossman,MD, 1999 BY THE ASDS,Dermatol.Surg. 1999;25:942-944

7. 12 juin 2016 - 7 ADVANCE IN DERMATO - COSMETOLOGY Vitamin K & Laser induced purpura Laser induced purpura is an unwanted side effect of pulsed dye laser treatment. Its hindrance to normal social interactions for days after treatment has a negative psychological impact on patients, who are often children receiving multiple treatments for congenital vascular malformation. Wendy.W. Lou,MD,Adelle T. Quintana,MD,Roy G. Geronemus,MD & Melanie C. Grossman,MD, 1999 BY THE ASDS,Dermatol.Surg. 1999;25:942-944

8. 12 juin 2016 - 8 ADVANCE IN DERMATO - COSMETOLOGY Any manipulation that curtails laser-induced purpura, either via laser technology or pharmacological agents, will prove to be extremely valuable. Wendy.W. Lou,MD,Adelle T. Quintana,MD,Roy G. Geronemus,MD & Melanie C. Grossman,MD, 1999 BY THE ASDS,Dermatol.Surg. 1999;25:942-944 Vitamin K & Laser induced purpura

9. 12 juin 2016 - 9 ADVANCE IN DERMATO - COSMETOLOGY Lou ET AL: study conducted in Laser and Skin Surgery, Dermatology Department, New York University, to evaluate the effect of vitamin K & retinol on laser induced purpura on non lesional skin. Wendy.W. Lou,MD,Adelle T. Quintana,MD,Roy G. Geronemus,MD & Melanie C. Grossman,MD, 1999 BY THE ASDS,Dermatol.Surg. 1999;25:942-944 Vitamin K & Laser induced purpura

10. 12 juin 2016 - 10 ADVANCE IN DERMATO - COSMETOLOGY Vitamin K in lower concentrations hastened the resolution of laser induced purpura significantly more than the control did. Wendy.W. Lou,MD,Adelle T. Quintana,MD,Roy G. Geronemus,MD & Melanie C. Grossman,MD, 1999 BY THE ASDS,Dermatol.Surg. 1999;25:942-944 Vitamin K & Laser induced purpura

11. 12 juin 2016 - 11 ADVANCE IN DERMATO - COSMETOLOGY Bruising resolved in 5 - 8 days with vitamin K cream applied twice a day and in 11- 13 days without treatment. Wendy.W. Lou,MD,Adelle T. Quintana,MD,Roy G. Geronemus,MD & Melanie C. Grossman,MD, 1999 BY THE ASDS,Dermatol.Surg. 1999;25:942-944 Vitamin K & Laser induced purpura

12. 12 juin 2016 - 12 ADVANCE IN DERMATO - COSMETOLOGY Mechanism of action Vitamin K applied topically was unlikely to alter systemic levels of vitamin K or to have effects centrally. Vitamin K hastens the resolution of laser induced purpura by peripheral effect, and the mechanism of action of topical vitamin K on this is still unknown. However it seems certain that it strengthens the vascular wall by reducing the tendency of capillaries to fragment. Wendy.W. Lou,MD,Adelle T. Quintana,MD,Roy G. Geronemus,MD & Melanie C. Grossman,MD, 1999 BY THE ASDS,Dermatol.Surg. 1999;25:942-944

13. 12 juin 2016 - 13 ADVANCE IN DERMATO - COSMETOLOGY Auriderm XO 30 ml – 75 ml – 4ml Stick

14. 12 juin 2016 - 14 ADVANCE IN DERMATO - COSMETOLOGY Auriderm XO Powerful Penetration Vectors Nanosomes formulation

15. 12 juin 2016 - 15 ADVANCE IN DERMATO - COSMETOLOGY The new generation of topical vitamin K Worldwide patented Auriderm XO

16. 12 juin 2016 - 16 ADVANCE IN DERMATO - COSMETOLOGY Aqua Alcohol denat Ethoxydiglycol Propylene glycol Caprilic capric triglyceride Sodium acrylate Sodium styrene Sodium acryloyldimethylaurate copolymer Triethanolamine PEG 10 maleate Polyisobutene Lecithin Nonoxynol 10 maleate Caprilyl capryl glucoside Acrylate copolymer Nonoxynol-4 EDTA disodium Auriderm XO Formula Phytonadione oxide (Vitamin K oxide) Ascorbyl Palmitate (Vitamin C) Tocopherol (Vitamin E) Tocopheryl Acetate (Vitamin E) Phospholipids

17. 12 juin 2016 - 17 ADVANCE IN DERMATO - COSMETOLOGY Mechanism of Action of Vitamin K

18. 12 juin 2016 - 18 ADVANCE IN DERMATO - COSMETOLOGY Vitamin K and Vitamin K oxide

19. 12 juin 2016 - 19 ADVANCE IN DERMATO - COSMETOLOGY Formation of naphtoquinones with UV light or sunlight Vitamin K Yes Vitamin K & retinol Yes Vitamin K oxideNO Vitamin K oxide & retinolNO

20. 12 juin 2016 - 20 ADVANCE IN DERMATO - COSMETOLOGY Photo-toxicity Pilot without UV Ref: BioHC 2003 Active with UV 6J/cm2 Viability on epidermis exposed to UV

21. 12 juin 2016 - 21 ADVANCE IN DERMATO - COSMETOLOGY Dermatological tolerance 5% of allergy occur in using vitamin K1 in various conditions on skin We have tested the discovered allergic patients to vitamin K We have found : Positive to vitamin K Negative to vitamin K oxide Ref: M. Castelain, Hop. St Marguerite Marseille, 2003

22. 12 juin 2016 - 22 ADVANCE IN DERMATO - COSMETOLOGY A D V A N T A G E S Faster action and better efficacy Colourless cream No photo-sensitivity No interaction with other components Far better skin tolerance No sensitivity to heat

23. 12 juin 2016 - 23 ADVANCE IN DERMATO - COSMETOLOGY Vitamin K oxide Decreases the appearance of broken vessels Decreases the appearance of rosacea Speeds up absorption of purpura associated with plastic surgery techniques, vascular laser treatments, sclerotherapy, or following any filling material Eliminates post laser resurfacing erythema Eliminates post chemical peel erythema Eliminates post microdermabrasion erythema Auriderm XO

24. 12 juin 2016 - 24 ADVANCE IN DERMATO - COSMETOLOGY Nanosome Delivery System AURIGA INTERNATIONAL developed the modern technology of vitamin K in nanosomes to 1.Improve penetration and absorption of vitamin K 2.Reduce the concentration 3.Provide sustained release of vitamin K for 12 hours 4.Decrease the cost

25. 12 juin 2016 - 25 ADVANCE IN DERMATO - COSMETOLOGY Nanosome biotechnology formulation brings to AURIDERM XO the best penetration through the skin. The system contains vitamin K which is a lipophilic substance within a monolayer of phosphotidylcholine. This unique technology results in particles of diameter of 180 nm Nanosome Delivery System

26. 12 juin 2016 - 26 ADVANCE IN DERMATO - COSMETOLOGY Vitamin C, E & A AURIDERM contains Vitamins C, E and A. The addition of those ingredients is very important because they have a synergistic action with vitamin K. Auriderm XO

27. 12 juin 2016 - 27 ADVANCE IN DERMATO - COSMETOLOGY Iron in the bivalent form (Ferrous) is soluble and easily eliminated. Iron in the trivalent form i.e. as Ferric is insoluble, not eliminated, and produces subcutaneous deposits of hemosiderin. Hemosiderin gives the unaesthetic spots with rusty color that will stay permanently. Auriderm XO

28. 12 juin 2016 - 28 ADVANCE IN DERMATO - COSMETOLOGY Fe + ²Fe + ³ Vitamin C, E Vitamins C and E are able to maintain the iron under a bivalent form (Ferrous), avoiding transformation to trivalent form (Ferric) Auriderm XO

29. 12 juin 2016 - 29 ADVANCE IN DERMATO - COSMETOLOGY Indications Erythrosis Rosacea Purpura Spider veins Post sclerosis of small vessels Bruising post vascular laser treatment Bruising post sclerotherapy Bruising post traumatic

30. 12 juin 2016 - 30 ADVANCE IN DERMATO - COSMETOLOGY Indications Purpura and bruising following: Liposuction Face or neck lift Blepharoplasty Rhinoplasty Any filling materials injection (New Fill, Botox, Collagen, Hyaluronic acid,…)

31. 12 juin 2016 - 31 ADVANCE IN DERMATO - COSMETOLOGY (55 years old) 얼굴 리프트 & 미용성형 Pre & Post cosmetic procedure 3일 후3일 후 6일 후6일 후 미용시술 후

32. 12 juin 2016 - 32 ADVANCE IN DERMATO - COSMETOLOGY Day 2Day 6Day 8 1 = Placebo 2 = AURIDERM Pre & Post cosmetic procedure

33. 12 juin 2016 - 33 ADVANCE IN DERMATO - COSMETOLOGY Female 52 years one year after sclerotherapy Post Sclerotherapy procedure

34. 12 juin 2016 - 34 ADVANCE IN DERMATO - COSMETOLOGY Female 51 year - 1 year post sclerotherapy Post Sclerotherapy

35. 12 juin 2016 - 35 ADVANCE IN DERMATO - COSMETOLOGY Blépharoplasty clinical trial Karavani 2004 Auriderm XO study Double blind Right eye with Auriderm XO

36. 12 juin 2016 - 36 ADVANCE IN DERMATO - COSMETOLOGY Right side: Auriderm XO Results after 4 days

37. 12 juin 2016 - 37 ADVANCE IN DERMATO - COSMETOLOGY Pr. Philippe Humbert, Besançon, France, 2005 Study on erythrosis on 24 patients  during 2 months  in double blind  compared with placebo Different levels of intensity: 1. Erythrosis AURIDERM XO !!! 2. Erythro-rosacea AURIDERM XO !!! 3. Rosacea 4. Rhinophyma AURIDERM XO & ERYTHROSIS

38. 12 juin 2016 - 38 ADVANCE IN DERMATO - COSMETOLOGY AURIDERM XO & ERYTHROSIS Results at d-56: Images made by videocapillaroscopy Images in 3D (videocapillaroscopy) Treated with placebo Treated with Auriderm XO

39. 12 juin 2016 - 39 ADVANCE IN DERMATO - COSMETOLOGY Method of application AURIDERM must be applied thinly twice a day, morning and evening, after cleansing the skin. Gently massage into skin until the gel is absorbed. AURIDERM is recommended for 10 to 15 days as preparatory skin care before and after surgical and medical cosmetic procedure. AURIDERM must be applied before all other beauty or cosmetic skin care products and can be used as a base for those preparations.

40. 12 juin 2016 - 40 ADVANCE IN DERMATO - COSMETOLOGY Precautions & Contre Indications Do not apply to wounds, mucous areas or eyes. Hypersensitivity to any component of the product.