1. Date of download: 5/28/2016 From: New Fibrate Use and Acute Renal Outcomes in Elderly Adults: A Population-Based Study Ann Intern Med. 2012;156(8):560-569. doi:10.7326/0003-4819-156-8-201204170-00401 Study flow diagram. Two or more of the exclusion criteria may have applied to certain patients. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 5/28/2016 From: New Fibrate Use and Acute Renal Outcomes in Elderly Adults: A Population-Based Study Ann Intern Med. 2012;156(8):560-569. doi:10.7326/0003-4819-156-8-201204170-00401 Acute (90-day) changes in serum creatinine level after fibrate and ezetimibe use. IQR = interquartile range. * Comparison of changes in serum creatinine level between fibrate and ezetimibe users by using the Wilcoxon rank-sum test. † Figure excludes an outlier with baseline estimated glomerular filtration rate below 60 mL/min per 1.73 m 2 and increase in serum creatinine level of 607 µmol/L (6.9 mg/dL) after fibrate use. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 5/28/2016 From: New Fibrate Use and Acute Renal Outcomes in Elderly Adults: A Population-Based Study Ann Intern Med. 2012;156(8):560-569. doi:10.7326/0003-4819-156-8-201204170-00401 Modification of the association between fibrate use and hospitalization for an increase in serum creatinine level, by diabetes, statin use, and CKD. The number of events (and the proportion of patients who had an event) was assessed by diagnostic codes. This underestimated the true event rate because codes are specific but not sensitive. We adjusted for age (per year); sex; accrual date (per year); socioeconomic status (per quintile of household income); the number of unique drug products in the 12 mo before accrual (per drug); use of nonsteroidal anti-inflammatory drugs, angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers, calcium-channel blockers, statins, or diuretics; and evidence of coronary artery disease, diabetes mellitus, hypertension, peripheral vascular disease, congestive heart failure, or CKD (using records from the 5 y before the index date). CKD = chronic kidney disease. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 5/28/2016 From: New Fibrate Use and Acute Renal Outcomes in Elderly Adults: A Population-Based Study Ann Intern Med. 2012;156(8):560-569. doi:10.7326/0003-4819-156-8-201204170-00401 Comparison of change in serum creatinine level among fibrate users and ezetimibe users, by baseline eGFR. eGFR = estimated glomerular filtration rate. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5. Date of download: 5/28/2016 From: New Fibrate Use and Acute Renal Outcomes in Elderly Adults: A Population-Based Study Ann Intern Med. 2012;156(8):560-569. doi:10.7326/0003-4819-156-8-201204170-00401 90-day changes in serum creatinine level after fibrate use, by baseline eGFR. eGFR = estimated glomerular filtration rate. * Comparison of changes in serum creatinine level between those with eGFR 60 mL/min per 1.73 m 2 or higher and those with eGFR below 60 mL/min per 1.73 m 2 by using the Wilcoxon rank-sum test. † Figure excludes an outlier with baseline eGFR below 60 mL/min per 1.73 m 2 and increase in serum creatinine level of 607 µmol/L (6.9 mg/dL) after fibrate use. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians