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Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection by Kartik Chandran, Nancy J. Sullivan, Ute Felbor, Sean P. Whelan, and.

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Presentation on theme: "Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection by Kartik Chandran, Nancy J. Sullivan, Ute Felbor, Sean P. Whelan, and."— Presentation transcript:

1 Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection by Kartik Chandran, Nancy J. Sullivan, Ute Felbor, Sean P. Whelan, and James M. Cunningham Science Volume 308(5728):1643-1645 June 10, 2005 Published by AAAS

2 Fig. 1. Endosomal cysteine proteases CatB and CatL are host factors for VSV-GPΔMuc infection. Kartik Chandran et al. Science 2005;308:1643-1645 Published by AAAS

3 Fig. 2. Endosomal cysteine proteases act directly on EboV GPΔMuc to mediate infection of Vero cells. Kartik Chandran et al. Science 2005;308:1643-1645 Published by AAAS

4 Fig. 3. Endosomal cysteineproteaseinhibitors diminish EboV-Zaire multiplication in Vero cells. Kartik Chandran et al. Science 2005;308:1643-1645 Published by AAAS


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