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Spinal cord stimulation restores locomotion in animal models of Parkinson's disease "... led us to hypothesize that stimulation... could alleviate motor.

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Presentation on theme: "Spinal cord stimulation restores locomotion in animal models of Parkinson's disease "... led us to hypothesize that stimulation... could alleviate motor."— Presentation transcript:

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2 Spinal cord stimulation restores locomotion in animal models of Parkinson's disease "... led us to hypothesize that stimulation... could alleviate motor symptons of PD by disrupting aberrant low- frequency oscillations."

3 Published by AAAS R. Fuentes et al., Science 323, 1578 -1582 (2009) Fig. 2. DCS restores locomotion and desynchronizes corticostriatal activity

4 Likelihood approaches. based on full model all the information efficient direct inference methods mle's

5 Conditional intensity. Simple case History H t = {  j  t} Pr{dN(t)=1 | H t } =  (t:  )dt  r.v Probability the points in [0,T) are t 1,...,t N Pr{dN(t 1 )=1,..., dN(t N )=1} =  (t 1 )...  (t N )exp{-   (t)dt}dt 1... dt N Split the time period into cells of width h [1-  (h)h][1-  (2h)h]...[1-.]  (K 1 h)h... K 1 h  t 1

6 log{[1-  (h)h][1-  (2h)h]...[1-.]} =  log[1-  (kh)h]  -   (kh)h  -   (t)dt

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