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Published byKerry Bates Modified over 9 years ago
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Spinal cord stimulation restores locomotion in animal models of Parkinson's disease "... led us to hypothesize that stimulation... could alleviate motor symptons of PD by disrupting aberrant low- frequency oscillations."
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Published by AAAS R. Fuentes et al., Science 323, 1578 -1582 (2009) Fig. 2. DCS restores locomotion and desynchronizes corticostriatal activity
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Likelihood approaches. based on full model all the information efficient direct inference methods mle's
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Conditional intensity. Simple case History H t = { j t} Pr{dN(t)=1 | H t } = (t: )dt r.v Probability the points in [0,T) are t 1,...,t N Pr{dN(t 1 )=1,..., dN(t N )=1} = (t 1 )... (t N )exp{- (t)dt}dt 1... dt N Split the time period into cells of width h [1- (h)h][1- (2h)h]...[1-.] (K 1 h)h... K 1 h t 1
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log{[1- (h)h][1- (2h)h]...[1-.]} = log[1- (kh)h] - (kh)h - (t)dt
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