Site Management Organization (SMO) Making Clinical Trials More Efficient Site Management Organization (SMO)

Core Strategic Offerings med fusion provides successful recruiting strategies by Increasing research and operational efficiencies Committing to communication and coordination We make clinical trials more efficient by Evaluating patients for rapid study startup and gathering data Maintaining a dedicated network of healthcare providers Denise – this is the critical slide in my opinion. It shows by Pharma should partner with med fusion for clinical trials. You might want to consider leading with this slide and then going into some of the background about med fusion followed by examples to support the statements regarding the value med fusion brings to clinical trials which are on this slide. As a result, we enhance the health, quality of life, and clinical value of patient care while increasing turn-around times and revenues.

med fusion Provides Solutions We promote timely and accurate payment by delivering Fully integrated Clinical Trial Management Systems (CTMS) Efficient accounts payable/receivable support We find appropriate studies by using Extensive portfolios of active clinical trials Strong relationships with sponsors We reduce costs by utilizing Professional budget analysts to identify hidden costs in clinical trials Field service specialists to identify and resolve front end issues Patient Service Center (PSC) networks to optimize operations

med fusion Provides Solutions We make recruiting patients easy with our Ability to evaluate patient populations for rapid study start-up Dedicated full-time call center We streamline the negotiation of contracts with Centralized contract review and negotiation for rapid turn-around Established Master Service Agreements with study sponsors We ensure you stay ahead of the competition by providing Ease of Use Model provides a platform to accelerate and drive execution at study site level Rewarding and dynamic work environments associated with research

Clinical Trials with SMO Support Industry Sponsors Requests Results med fusion Rapid study startup Contract and budget negotiation Patient service centers Site management personnel Field service specialists Study kit inventory and distribution Affiliations with central IRBs Subcontracts and payments Clinical trials and patient data Sites Oncology GI/GU CNS Immunology CV ID 5

Clinical Trial Site Management Support Connecting Sponsors and Physicians Clinical Trials Site Management and Recruitment Data Industry Sponsors Manages trials and testing Field service support Clinical Trial Site Management Support Test results Physician Offices

Clinical Trial Site Management Support Connecting Sponsors and Physicians Clinical Trials Site Management and Recruitment Data Industry Sponsors Manages trials and testing Field service support Reference testing Clinical Trial Site Management Support Testing Physician Office Labs and Patient Service Centers Test results Community Pathology Health System Laboratories Consultations Test results Populates database Electronic Medical Records Physician Offices

North Texas Market med fusion provides professional, high-quality clinical research through a dedicated network of geographically distinct clinical investigative sites with large, readily available patient populations. We deliver the following resources through our unique partnerships with Baylor Healthcare System (BHCS), U.S. Oncology, and Texas Oncology. Medical resources Patient resources 624,514 outpatient registrations 235 patient access points 388,951 ER visits 41 satellite outpatient clinics 127,415 admissions 26 hospitals 6,300 medical staff members 21 ambulatory surgery centers 3,532 licensed beds 7 short-stay surgical hospitals

The med fusion Advantage To deliver effective clinical trial programs, med fusion will Implement ongoing site relationship training Reduce patient drop-out rates Increase patient enrollment rates Enable the expansion of projects to a large pool of potential patients Build robust databases for future research and outcomes projects

The med fusion Advantage To deliver effective clinical trial programs, med fusion will Increase physician participation in clinical trials Provide an extensive IT system to access clinical trial information Integrate systems and services to eliminate clinical trial delay Support and enhance central and local IRB interactions Distribute study kits on an as-needed basis through advanced logistics courier, tracking, and monitoring systems

Field and Patient Service Centers med fusion provides a fully integrated network of field and patient service centers that Lower operation costs Consolidate the processing of accounts payable/receivable Integrate information about clinical trial availability into test results Optimize supply storage, management, and delivery Reduce patient attrition through dedicated field service support Denise – I think it is Field Service

Field and Patient Service Centers Skilled phlebotomists who are patient friendly and service oriented Advanced scheduling of appointments and appointment reminders med fusion service centers ease the burden of clinical trials via Study kit distribution on an as-needed basis Denise – I think it is Field Service

Enhancing Patient-Site Relationships The patient-site relationship is key to retention. med fusion builds and maintains strong relationships by Identifying key factors that draw patients to clinical trials Integrating field service specialists with sites Ensuring adequate resources for patient recruitment Developing patient recruitment and referral centers Automating systems to vastly increase efficiency Minimizing interference with other physician activities

The Bottom Line Potential Revenue $565,714 $1,414,285 $2,828,571 Amount of 10% Market Share 25% 50% Investigator Sites 6 15 30 Studies 5 13 26 Study Subjects Enrolled 113 283 566 Study Subject Visits 170 424 849 Potential Revenue $565,714 $1,414,285 $2,828,571 Assumptions 300 bed hospital service area (180 MDs to support) 22 patients per study 20 visits per patient per study per year Average reimbursement per patient is $5,000 Average of 3 MDs per site Average of 18 months per clinical trial

Making Clinical Trials More Efficient When you rely on med fusion for Site Management Organization, we will Provide you with successful recruiting strategies. Connect you with physicians to successfully initiate and operate patient studies. Deliver professional, high-quality clinical research through a dedicated network of geographically distinct clinical investigative sites with large, readily available patient populations. Implement a fully integrated network of field and patient service centers that benefit your organization.

References Acurian Whitepaper Series: Scott H. Connor, VP Marketing,An Integrated Approach for Clinical Trial Patient Retention. Elvidge S. Importance of Patient-Retention Strategies. Life Science Leader. April 2010. Kaitin KI. Growing Protocol Design Complexity Stresses Investigators, Volunteers. Impact Report. Tufts Center for the Study of Drug Development. 2008. Wipke-Tevis, D. Impact of the Health Insurance Portability and Accountability Act of participant recruiting and retention. Western Journal of Nursing. 2008;30:399-53. 5th Annual Patient Recruitment & Retention Conference; September 24-25, 2007; Washington, DC; data presented by John Benbrook and Malcolm Bohm of MMG & Trialytics, Inc. Volunteer Demographics Center for Information & Study on Clinical Research, Clinical Trial Facts and Figures, 2006.