Impetigo Mupirocin; (bacitracin and neomycin, are less effective.) numerous lesions or not responding to topical agents: oral antimicrobials effective against both S. aureus and S. pyogenes.

Impetigo

Folliculitis Local measures such as saline compresses and topical antibacterials (e.g., mupirocin) are usually sufficient to control the infection.

Furuncles and Carbuncles Most furuncles: moist heat. carbuncle, a furuncle with surrounding cellulitis or fever, or a furuncle located about the midface: an antistaphylococcal antibiotic (e.g., dicloxacillin). In a penicillin-allergic adult: clindamycin, or co-trimoxazole. Patients with moderate to severe disease are best treated with initial parenteral therapy (e.g., vancomycin, linezolid, or daptomycin)

Erysipelas Mild early cases of erysipelas in an adult may be treated with oral penicillin V (500 mg every 6 hours) or initial IM procaine penicillin (600,000 units once or twice daily). Erythromycin (250 to 500 mg orally every 6 hours) or other macrolides are suitable alternatives. More extensive erysipelas, hospitalization and parenteral aqueous penicillin G (2,000,000 units every 6 hours). If differentiation from cellulitis is difficult: a PRP (nafcillin or oxacillin), a cephalo 1, or therapy against MRSA.

cellulitis  Outpatient: PRP (nafcillin or oxacillin), cephalo 1 MRSA is suspected: clindamycin, TMP-SMX, doxycycline or minocycline + B-lactam (eg, amoxicillin), linezolid.  Inpatient: PRP, cephalo 1 MRSA is suspected: vancomycin, linezolid, daptomycin, clindamycin

Diabetic Ulcers Mild: PO cephalexin, dicloxacillin, clindamycin Moderate to severe: IV clindamycin plus a cephalo 3, clindamycin plus a fluoroquinolone, piperacillin-tazobactam, carbapenem, ampicillin-sulbactam, ticarcillin-clavulanate.

Diabetic Ulcers

Gastroenteritis ciprofloxacin, ofloxacin, levofloxacin, norfloxacin Azithromycin

Typhoid Fever

Gastroenteritis (nosocomial)

CNS Infections (Meningitis)

CNS Infections (Brain Abscess)

CNS Infections (Shunt Infection) vancomycin plus either cefepime, ceftazidime, or meropenem

CNS Infections (Subdural Empyema, Epidural Abscess) vancomycin plus cefepime or ceftazidime + metronidazole or meropenem In spinal cases, anaerobic coverage is not required.

CNS Infections (Suppurative Intracranial Thrombophlebitis) vancomycin plus cephalo 3 or 4 + metronidazole or meropenem