Intro-BIOL318 Immunology Instructor: Dr. Kathy Szick-Miranda Office: Science I 316 Phone: Web: Office hours: M 10-12; T 3:30-5; W 10-11:30 Lecture and Discussion: T R 10:00-11:40am, Sci II 180

Intro-BIOL318 Immunology Course Objectives: Upon completion of this course students will be expected to: Describe the various cells and organs of the immune system, including the role of each during the immune response. Compare and contrast innate and acquired immunity, including their specific components and effector mechanisms. Describe antigens and antibodies and their interactions. Discuss the immune response to specific pathogens.

Intro-BIOL318 Immunology Assignment Point Values: Exam I100pts Exam II 100pts Final Exam (Exam III)100pts Quizzes (top 5 scores) 50pts TOTAL 350pts

Historical Perspective  Immunity - state of protection from an infectious disease.  430 BC – Greek historian Thucydides - Athenian plague  15 th century – Chinese attempts to induce immunity  1718 – Mary Wortley Montagu – innoculated her children  1798 – Edward Jenner – milkmaids and cowpox/smallpox

Historical Perspective  early 1880’s – Cholera and chickens Attenuation hypothesis  1881 – Testing the hypothesis with anthrax and sheep  1885 – Rabies vaccine Louis Pasteur

Historical Perspective  Behring and Kitasato – link serum to immunity  1883 – Metchnikoff – links cells (phagocytes) to immunity  early 1900’s – many functions of immune serum  1930’s – Kabat - immunoglobulin/antibodies  1950’s – Glick – two types of lymphocytes

Historical Perspective  1900 – Paul Ehrlich – Selective theory  1950’s – Jerne, Talmadge and Burnet – clonal selection theory

Historical Perspective

Infection and Immunity  pathogens – organisms causing disease  pathogenesis – the means by which disease-causing organisms attach a host.

Innate and Adaptive Immunity Innate 1 st line of defense Non-specific mechanisms Phagocytes and recognition molecules Adaptive 2 nd line of defense Highly specific mechanisms Lymphocytes, antigen specific receptors, antibodies

Components of Adaptive Immunity T Lymphocytes

Innate and Adaptive Immunity

Immune Dysfunction  Allergies and asthma  Graft rejection  Autoimmune disease  Immunodeficiency