Effects of the Combination of Microfracture and Self- Assembling Peptide Filling on the Repair of a Clinically Relevant Trochlear Defect in an Equine Model.

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Presentation transcript:

Effects of the Combination of Microfracture and Self- Assembling Peptide Filling on the Repair of a Clinically Relevant Trochlear Defect in an Equine Model by Rachel E. Miller, Alan J. Grodzinsky, Myra F. Barrett, Han-Hwa Hung, Eliot H. Frank, Natasha M. Werpy, C. Wayne McIlwraith, and David D. Frisbie J Bone Joint Surg Am Volume 96(19): October 1, 2014 ©2014 by The Journal of Bone and Joint Surgery, Inc.

Schematic illustration of core biopsy sample collection for histologic (A and C), immunohistochemical (IHC) (B and D), biochemical (1 through 7), and biomechanical (1 through 7) evaluations of repair tissue (2, 3, and 4) and surrounding native tissue (1, 5,... Rachel E. Miller et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Representative MRI results (proton-density fat-saturated). Rachel E. Miller et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Radiographically assessed sclerosis was greater in defects treated with only microfracture (MF) compared with untreated defects and defects treated with KLD only and with KLD plus microfracture, both across the fifty-two-week study period (Fig. 3-A) and at... Rachel E. Miller et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Representative photographs of defects at the time of necropsy. Rachel E. Miller et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Representative histologic image from each treatment group (hematoxylin and eosin). Rachel E. Miller et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Across the fifty-two-week study period, structural integrity of the proximal repair tissue was more normal for defects treated with only microfracture (MF) compared with only KLD and with microfracture plus KLD. Structural integrity was scored from 0 to 2,... Rachel E. Miller et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Across the fifty-two-week study period, aggrecan (Fig. 7-A) and type-II collagen (Fig. 7-B) contents in the distal repair tissue were greatest for microfracture (MF)-only treatment. Rachel E. Miller et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.