15 June, 2003medXchange© 2003 Private & Confidential 1 PATIENT CENTRIC META DATA BASE AND INFORMATION SYSTEM FOR CLINICAL STUDY AND MEDICAL DATA MANAGEMENT

15 June, 2003medXchange© 2003 Private & Confidential 2 Innovative Approach to Clinical Studies Complete medical documentation Out of medically credible trustworthy sources Interface to medical information systems Clinics, Laboratories, Radiology, Biosensors, Dentists, etc. Clinical Study Profiles Dynamic interactive profile changes Case - disease management EBM for good medical practice - golden standards Confidential data exchange point All patient related medical and health data For authorised healthcare professionals

15 June, 2003medXchange© 2003 Private & Confidential 3 Key Objectives - Rationalization Rationalization of clinical studies Increase efficiency & accuracy of clinical studies Increase participation over multiple countries Increase efficiency of treatments

15 June, 2003medXchange© 2003 Private & Confidential 4 Key Objectives - Quality Quality of clinical studies Enable the delivery of high quality clinical studies  Integration of the patient in the clinical study process  Interactive networking of healthcare professionals over open platform Provide the highest quality service  24 / 7 interactive medical information from trustworthy sources  Healthcare consumer protection and early warning

15 June, 2003medXchange© 2003 Private & Confidential 5 Continuity of clinical study documentation Consulting Physician Dispensed Medication Laboratories Second Opinion Medical Call Center Hospital & Clinic Therapists Patient Centric Integrated Electronic Medical Record Physician

15 June, 2003medXchange© 2003 Private & Confidential 6 Patient Centric Clinical Study Documentation Meta Database Physician Medical Record Medical Information & Images Output Input Output Input I E M R Clinical Medical Records Dispensed Medication Disease Profile Laboratory Results Medical Call Center Clinical Study Analysis Clinical Study Profile Case Report Forms

15 June, 2003medXchange© 2003 Private & Confidential 7 Integrated Electronic Medical Record Intuitively understandable by healthcare professionals worldwide Multi Language Ergonomically structured to physicians working methods Easy to consult by patient

15 June, 2003medXchange© 2003 Private & Confidential 8 Management of "Risk Patients" Case – Disease management  Using Evidence Based Medecin (EBM) and good medical practice Interface or data migration out of other medical information systems  Bio-sensors, laboratories, hospitals  Specialised medical documentation (Orthopedic, cardiology, nephrology, radiology)

15 June, 2003medXchange© 2003 Private & Confidential 9 Clinical Study Profile Specific for Study Interactive Create & Maintain Profile Questionnaires Detailed Study Profile Medical Knowledge Base Analysis

15 June, 2003medXchange© 2003 Private & Confidential 10 Medical Data Protection & Security Patient is legal owner of data in IEMR Access rights controlled by patient Patient can request data to be rectified Patient data in meta database is anonymous Data remains private between physician and patient

15 June, 2003medXchange© 2003 Private & Confidential 11 Data Protection & Access Management Patient controls access to record Certain data updated by patient Medical data certified by physician All data traced to source Physician can restrict access to data Physician & Patient notified of updates EC Health Card or USB Key “access key”

15 June, 2003medXchange© 2003 Private & Confidential 12 Physician Clinical Trial Professional Key Patient Key Research Key Physician SmartCard Patient SmartCard Research SmartCard Physician & Patient Card access Medical Records Research Card access analysis Clinical Research Patient

15 June, 2003medXchange© 2003 Private & Confidential 13 Healthcare Rationalization 20% shortening of time to detect problems 40% clinical study infrastructure cost reduction 30% reduction of data gathering and reporting costs Clinical & Medical Studies

15 June, 2003medXchange© 2003 Private & Confidential 14 Healthcare Rationalization 50% efficiency of patient admission processing time 20% reduction of medical exams and tests 30% efficiency in diagnosis time for emergencies Hospital & Clinic 30% reduction of patient history research time 20% reduction in patient diagnosis time 20% reduction of medical exams and tests Physician

15 June, 2003medXchange© 2003 Private & Confidential 15 Healthcare Rationalization Patient Greater medical security – one IEMR - Improved healthcare treatment Improved quality of healthcare Optimization of healthcare services  Early warning system in case of problems with medical implants and drugs  Supervision of compliance with medical regulations

15 June, 2003medXchange© 2003 Private & Confidential 16 access authorized by patient platform dedicated to healthcare professionals open standard for medical data exchange using existing technologies and investments integrating not replacing current systems The patient centric meta database

15 June, 2003medXchange© 2003 Private & Confidential 17 Designed by physicians for physicians Complete patient medical data and documentation Follows physician working methods Patient disease support and profile Patient pro-active health support and profile Disease and health risk analyis The IEMR & Medical Knowledge Base