Dolly sheep Directed by : nooralhuda ibrahim. cloning cloning is the creation of a genetically identical copy cloning is the creation of a genetically.

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Presentation transcript:

Dolly sheep Directed by : nooralhuda ibrahim

cloning cloning is the creation of a genetically identical copy cloning is the creation of a genetically identical copy How ? How ?

Why was Dolly created? In mice it was possible to genetically modify these cells. In mice it was possible to genetically modify these cells. But they found that the process of cloning the best results for the sheep and not the mouse But they found that the process of cloning the best results for the sheep and not the mouse

birth where the cell nucleus from an adult cell is transferred into an unfertilised oocyte The hybrid cell is then stimulated to divide by an electric shock, and when it develops into a blastocyst it is implanted in a surrogate mother. where the cell nucleus from an adult cell is transferred into an unfertilised oocyte The hybrid cell is then stimulated to divide by an electric shock, and when it develops into a blastocyst it is implanted in a surrogate mother.

life Dolly lived for her entire life at the Roslin Institute. Dolly lived for her entire life at the Roslin Institute. She was born in April The next year Dolly produced twin lambs Sally and Rosie, and she gave birth to triplets Lucy, Darcy and Cotton in the year after that. She was born in April The next year Dolly produced twin lambs Sally and Rosie, and she gave birth to triplets Lucy, Darcy and Cotton in the year after that. In the autumn of 2001, at the age of five, Dolly developed arthritis and began to walk stiffly, but this was successfully treated with anti-inflammatory drugs. In the autumn of 2001, at the age of five, Dolly developed arthritis and began to walk stiffly, but this was successfully treated with anti-inflammatory drugs. arthritis anti-inflammatory arthritis anti-inflammatory

death On 14 February 2003, Dolly was had a progressive lung disease and severe arthritis. On 14 February 2003, Dolly was had a progressive lung disease and severe arthritis. A Finn Dorset such as Dolly has a life expectancy of around 11 to 12 years, but Dolly lived to be only six years of age. A Finn Dorset such as Dolly has a life expectancy of around 11 to 12 years, but Dolly lived to be only six years of age. A post-mortem examination showed she had a form of lung cancer called Jaagsiekte, which is a fairly common disease of sheep and is caused by the retrovirus JSRV. A post-mortem examination showed she had a form of lung cancer called Jaagsiekte, which is a fairly common disease of sheep and is caused by the retrovirus JSRV.

reference 1- McLaren A (2000). "Cloning: pathways to a pluripotent future". Science 288 (5472): 1775 – 80. doi: /science PMID McLaren A (2000). "Cloning: pathways to a pluripotent future". Science 288 (5472): 1775 – 80. doi: /science PMID doi /science PMID doi /science PMID a b "Dolly the sheep clone dies young", BBC News, Friday, 14 February a b "Dolly the sheep clone dies young", BBC News, Friday, 14 February 2003a b "Dolly the sheep clone dies young"a b "Dolly the sheep clone dies young" 3- "Is Dolly old before her time?". BBC News (London). 27 May Retrieved "Is Dolly old before her time?". BBC News (London). 27 May Retrieved "Is Dolly old before her time?" BBC News "Is Dolly old before her time?" BBC News ess.com/2009/11/ d4c4c.jpg&imgrefurl= pecies-sarah-schaschek-david-gray-and-diana- pozo/&h=380&w=593&sz=74&tbnid=GIfk3Z55D7tsmM:&tbnh=87&tbnw =135&prev=/images%3Fq%3Ddolly%2Bthe%2Bsheep&hl=ar&usg=__- NzZgUMrhYnT_0sbciuBg5jqE3s=&ei=G0HxS47cNoqqsAaD9LSxBg&sa=X &oi=image_result&resnum=8&ct=image&ved=0CCkQ9QEwBw 5- ess.com/2009/11/ d4c4c.jpg&imgrefurl= pecies-sarah-schaschek-david-gray-and-diana- pozo/&h=380&w=593&sz=74&tbnid=GIfk3Z55D7tsmM:&tbnh=87&tbnw =135&prev=/images%3Fq%3Ddolly%2Bthe%2Bsheep&hl=ar&usg=__- NzZgUMrhYnT_0sbciuBg5jqE3s=&ei=G0HxS47cNoqqsAaD9LSxBg&sa=X &oi=image_result&resnum=8&ct=image&ved=0CCkQ9QEwBw ess.com/2009/11/ d4c4c.jpg&imgrefurl= pecies-sarah-schaschek-david-gray-and-diana- pozo/&h=380&w=593&sz=74&tbnid=GIfk3Z55D7tsmM:&tbnh=87&tbnw =135&prev=/images%3Fq%3Ddolly%2Bthe%2Bsheep&hl=ar&usg=__- NzZgUMrhYnT_0sbciuBg5jqE3s=&ei=G0HxS47cNoqqsAaD9LSxBg&sa=X &oi=image_result&resnum=8&ct=image&ved=0CCkQ9QEwBw ess.com/2009/11/ d4c4c.jpg&imgrefurl= pecies-sarah-schaschek-david-gray-and-diana- pozo/&h=380&w=593&sz=74&tbnid=GIfk3Z55D7tsmM:&tbnh=87&tbnw =135&prev=/images%3Fq%3Ddolly%2Bthe%2Bsheep&hl=ar&usg=__- NzZgUMrhYnT_0sbciuBg5jqE3s=&ei=G0HxS47cNoqqsAaD9LSxBg&sa=X &oi=image_result&resnum=8&ct=image&ved=0CCkQ9QEwBw