Receptor-Ligand Interactions.. k 1 R + L  RL K -1 [RL] Ka = _ [R] [L] Affinity constant (M -1 ) [R] [L] Kd = __ [RL] Dissociation constant.

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Presentation transcript:

Receptor-Ligand Interactions.

k 1 R + L  RL K -1 [RL] Ka = _____ [R] [L] Affinity constant (M -1 ) [R] [L] Kd = ______ [RL] Dissociation constant (M)

Common strategies used in many signaling pathways.

Acetylcholine muscarinic receptor of endothelial cells.

PIP3 or phosphatidyl 3,4,5 tri-phosphate

Provide binding sites for PH domain proteins.

PI-3Kinase and PKB/Akt pathway.

Ubiquitin with 7 lysine residues (K6, K11, K27, K29, K33, K48, and K63).

Frequently encountered signaling pathways.

MAPKAP Ternary Complex Factor Serum Response Factor

(K48)

(IL-1/TNF receptor Associated Kinase) (TNF receptorAssociated Factor E3 Ubiquitin Ligase) (TGFb Activated Kinase) (NFkB Inducing Kinase) (Inhibitor of kappa B Kinase)

TRAF6: TNF  associated factor IRAK: Il-1 R activated Kinase TAK1: TGF  Activated Kinase 1.