Quick quiz on Anti-helminthics By Sarah E.

Anti-helminthics Name the ones that treat trematodes. – Praziquantel (Major trematode disease=schistosomiasis (snails!) Name the ones that treat cestodes – Niclosamide (not in US though) – Praziquantel – Albendazole for cysticercosis

Anti-helminthics Name the ones that treat nematodes – Mebendazole – Thiabendazole – Albendazole – Pyrantel – Diethylcarbamazine – ivermectin

Anti-helminthics Which one kills the ova of cestodes? – Praziquantel Which one is the DOC for filariasis? – Diethylcarbamazine or ivermectin Which ones can give the mazotti reaction? – Ivermectin, diethylcarbamazine Which one is the DOC for strongyloides? – ivermectin

Anti-helminthics Which ones are contraindicated in pregnancy? – Praziquantel, albendazole, pyrantel, ivermectin Which one is the DOC for cystic hydatid disease? – Albendazole Which can be used to treat pinworm? – Mebendazole, albendazole

Anti-helminthics Which is contraindicated in occular cysticercosis? – Praziquantel Which is contraindicated in occular oncocerciasis? – Diethylcarbamazine Which can topically treat “creeping eruption” and strongyloidiasis? – thiabendazole

Anti-helminthics Why is thiabendazole better topically than orally? – Increased absorption orally leads to more toxic effects Which is contraindicated in meningitis? – Ivermectin Why? – It affects GABA Which is thought to block microtubule function? – mebendazole

Anti-helminthics Which works by increasing Ca 2+ permeability? – Praziquantel (also kills ova of cestodes) Which acts a both a muscle depolarizer and cholinesterase inhibitor? – Pyrantel Which one stops attachment of the worms to the intestine? – diethylcarbamazine

Anti-helminthics What is an alternate DOC for nematodes? – Pyrantel What are the side effects? – Dizziness, drowsiness, GI effects, headache, can’t take it when pregnant What is the primary DOC for nematodes? – Diethylcarbamazine or ivermectin