Protein Function What happens when a protein’s environment is changed?changed

Protein Structure based on the sequence of amino acids. If the sequence changes, the protein changes

Protein Folding The structure (how its folded) of the protein affects the function. Changing one amino acid can change the shape which alters the function resulting in genetic disorders

Structure Meets Function: Making a Protein TASK: Create a protein (Pencil Transferase) with a pipe cleaner that can move a pencil from one desk to another.

Structure Reflects Function The SHAPE of the pipe cleaner allows it to perform its FUNCTION Just like pipe cleaners, proteins are folded into specific shapes to perform their functions! Handle Domain Pencil-Binding Domain

Videoclips: VideoclipVideoclip – One Wrong Letter – Tay Sachs VideoclipVideoclip – Finding Cures is Hard– Cystic Fibrosis

Cn3D – Viewing 3-D Proteins Hemoglobin BRCA1 – no mutation (methionine - M) BRCA1 BRCA1 – mutation (Loc arginine - R) Videoclip: BRCA1 and Breast Cancer Videoclip – Complexity in Proteins Videoclip

The Genetic Code - 20 amino acids Uses 3 letter “words” (codons) that translate to amino acids 3 bases = codon AUG = start UAG,UAA,UGA = stop