Insulin Resistance Progression to Diabetes. Hypertension: BP >140/90 Dyslipidemia: ◦TG >150 mg/dL (1.7 mmol.L) ◦HDL-C <35 mg/dL (0.9 mmol/L) Obesity (central):

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Presentation transcript:

Insulin Resistance Progression to Diabetes

Hypertension: BP >140/90 Dyslipidemia: ◦TG >150 mg/dL (1.7 mmol.L) ◦HDL-C <35 mg/dL (0.9 mmol/L) Obesity (central): BMI >30 kg/M2 ◦Waist girth > 94 cm (37 inch) ◦Waist/Hip ratio > 0.9 Impaired Glucose Handling: IR, IGT or DM ◦FPG >110 mg/dL (6.1 mmol/L) ◦2 hr. PG >200 mg/dL (11.1 mmol/L)

Inflammation

Stage 1 – Early Insulin Resistance

Treatment recommendations for Stage 1

Stage 2 – Elevated Insulin Graph represents patient's stage of prediabetes.

Treatment recommendations for stage 2

Stage 3: Beta-Cell Dysfunction Graph represents patient's stage of pre-diabetes.

Treatment recommendations for stage 3

Inflammation Markers High-sensitivity C-Reactive Protein (hs-CRP) High hs-CRP associated with: Chronic inflammatory state. Insulin resistance (independent of obesity) and increased risk of type 2 diabetes. Hypertension, metabolic syndrome, and aging. Increased risk of coronary artery disease, peripheral artery disease, and increased risk of cardiac death in individuals with previous heart attack.

Treatment Options to reduce hs- CRP: