Androgenic Steroids Overall Organization of the Topic

Slides:

Advertisements

Similar presentations

Testosterone and 5-Alpha Reductase Inhibitors Stephen Chromi, PharmD PGY-1 Pharmacy Practice Resident St. Joseph’s/Candler Health System.

Advertisements

Number of Nuclear Positions and Steroid Classification

Muscular System Day 2. Muscle Development Hypertrophy – The growth and increase of the size of muscle cells Example? Bodybuilding.

Steroids By: Mark Avery.

Anabolic Steroids By: Chris Leuzinger & Jeff Wiebe-Connolly.

At the Clinic Scenario # 1

Pharmacology in Nursing Men’s Health Drugs

Mosby items and derived items © 2011, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. CHAPTER 35 Men’s Health Drugs.

By: Maddie Routhier. Production  Testosterone is primarily produced in the testes  A small amount is produced in the adrenal glands.

Gonad Hormones : Male Prof.Dr.Gülden Burçak

Female Sex Hormones (Estrogens and Progestins)

MALE ‘NADS BY RIO JAUREGUI & MEGAN QUINN 7 TH PERIOD.

Female Sex Hormonal Steroids Overall Organization of the Topic  Structure and nomenclature - Estradiol, estrone, estriol, and progesterone  Biosynthesis.

Steroids Steroids Some questions we need answers to Some questions we need answers to What are steroids? What are steroids? Who takes steroids Who takes.

Anabolic-Androgenic Steroids

Androgens agonists and antagonists. What are androgens ? Steroid derived from cholesterol found in males and females Androgens produced by testes: 1.Testesterone.

ESTROGENS AND ANDROGENS

Drugs affecting reproductive system

Human Endocrine Physiology March 13, Binding Proteins.

END ‘Hot topic’ DHEAS miraculous potion or snake oil? © Dr S Nussey &  IOS.

Chapter 37 Sex Hormones. Copyright 2007 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved Sex Hormones Endocrine.

Testosterone By: Lisa Krivoshein & Carli Brown. Steroid Hormone steroid that acts as a hormone.

BIOLOGICAL MODELS International Science Forum on Computational Toxicology May 21–23, 2007 Research Triangle Park, North Carolina Hugh A. Barton 1, Laura.

Supplements & Steroids. What is Testosterone? the principle male sex hormone and an anabolic steroid A Hormone that produces Male Characteristics Maintenance.

STEROIDS BY: CAMERON VASSAR APRIL 23 RD 2015 CHEMISTRY.

ANABOLIC STEROIDS 1 University Of Nairobi Department Of Public Health, Pharmacology & Toxicology JPT 341 Pharmacology &Toxicology BVM 3 RD Year Lecture.

1 Male Reproductive System. 2 Basic Anatomy Testes (gonads) Encased within scrotum and stored outside body Scrotum expands and contracts to heat and cool.

Androgens & Antiandrogens Munir Gharaibeh, MD, PhD, MHPE Faculty of Medicine The Jordan University April 2014.

PowerPoint ® Lecture Slides prepared by Janice Meeking, Mount Royal College C H A P T E R Copyright © 2010 Pearson Education, Inc. 27 The Male Reproductive.

Drugs affecting reproductive system Basic & Clinical Pharmacology.

HORMONES Chemical messengers Produced by endocrine glands Controlled by pituatory gland (controlled by hypothalamus) Released into bloodstream in small.

Steroid Hormones.

Anabolic Steroids By: The Malik’s.

Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. Chapter 65 Androgens.

Hormones Topic B6. Production and function (B.6.1) primarily chemical messengers produced in endocrine glands – –organs that secrete directly into bloodstream.

Anabolic Steroids.

Anabolic Androgenic Steroid Metabolic Pathway

Lec. 5 Gonadal hormones. The ovaries and testis are exocrine (ova, sperm) as well as endocrine (hormonal) in function. They develop under the influence.

414 PHG Substance of abuse.  By the end of this lectures the student should be able to:  Discuss the source and sythesis of anabolic hormones  Explain.

Steroid Hormones.

Male sex hormones Androgens Types: 1.Natural androgens: – Androsterone and testosterone 2.Synthetic androgens: – Testosterone propionate. – Anabolic.

Hormones Topic B6. Production and function (B.6.1) primarily chemical messengers produced in endocrine glands secreted directly into bloodstream and transported.

Estrogens and Androgens

Oral Contraceptives Estrogen and Progestin. 2 Hormonal contraceptives Hormonal contraceptives contain either a combination of an estrogen and a progestin.

AIS (Androgen Insensitivity Syndrome) and the androgen receptor (AR) Sam Trammell.

The Gonadal Hormones & Inhibitors By S. Bohlooli, PhD School of Medicine, Ardabil University of Medical Sciences.

Androgens Also called androgenic hormone or testoid

Anabolic Steroids. “Steroids” Corticosteroidsvs. Anabolic steroids -reduces swelling -synthetic testosterone -reduces inflammation -increase size, strength.

IMPORTANCE OF TESTOSTERONE TO BUILD & DEVELOP YOUR MUSCLES THE BEST OF ANABOLIC STEROIDS.

( AB ) USE HORMONES PERFORMANCE-ENHANCING ( AB ) USE OF HORMONES Dr, Hossein Zaeri Assistant Professor of Pediatric Endocrinology & Metabolism.

Male sex hormones By Akrum Hamdy. Male sex hormones Androgens Synthesis& secretion Regulation Pharmacological actions Pharmacokinetics Preparations Therapeutic.

Androgens & Antiandrogens. The testis has two major functions: 1. Spermatogenesis occurring within the seminiferous tubules 2. Production of androgenic.

Hormones of Testes - Testosterone Lecture NO: 2nd MBBS

Copyright © 2017, Elsevier Inc. All rights reserved.

Diagrammatic representation of the mechanism of action of testosterone on target cells. Testosterone (T) circulates in association with sex hormone–binding.

Chapter 65 Androgens 1.

Steroids & Muscle Growth

Steroids Overall Organization of the Lecture Series

Steroids Overall Organization of the Lecture Series Introduction

Androgenic Steroids Overall Organization of the Topic

Androgenic Steroids Overall Organization of the Topic

Steroids Overall Organization of the Lecture Series Introduction

Estrogenic Steroids Overall Organization of the Topic

Drugs affecting reproductive system

Androgenes and Antiandrogenes

Anjanette Acosta Physiology 3

Spermatogenesis Production of sperm cells

Androgenes and Antiandrogenes

Estrogenic Steroids Overall Organization of the Topic

The Pharmacology of Androgens

Presentation transcript:

Androgenic Steroids Overall Organization of the Topic Overall mechanism of steroid hormone action Structure of male sex hormones - Testosterone, androstendione, and 5a-dihydrotestosterone Nomenclature of androgenic steroids Physiological activities - Androgenic and anabolic activities Biosynthesis and metabolism of testosterone Structure activity relationships - Generalizations Androgen antagonists - Finasteride, danazol, bicalutamide and flutamide

Steroid Hormones Overall Mechanism of Steroid Hormone Action (intracellular) (intranuclear) proteins Intracellular effects extracellular effects transcription translation dimerization DNA (extracellular)

Androgenic Steroids Structure and Nomenclature Testosterone Androstendione (Andro) (17b-hydroxy-androst-4-en-3-one) 3D-structure (androst-4-en-3,17-dione) 5a-Dihydro-testosterone (17b-hydroxy-5b-androstan-3-one) 3D-structure

Androgenic Steroids – Physiological Activities Primarily two activities – Androgenic and Anabolic Androgenic Activity Growth and development of male sex organs Important for male sex drive and performance Development of secondary sexual characteristics Important role in spermatogenesis Anabolic Activity Development of muscle mass Reverse catabolic or tissue-depleting processes

Androgenic Steroids - Physiological Activities Andro is available over the counter!!

Biosynthesis and Metabolism of Testosterone Cholesterol Pregnenolone Testosterone Other metabolites 5a-DHT Androstendione

Structure Activity Relationships in Androgens Anabolic Androgenic Testosterone 1 1 (injectable) Testosterone 1 1 esters (injectable) R = COCH2CH3 propionate = CO(CH2)5CH3 enanthate = COCH2CH2(C5H9) cypionate

Structure Activity Relationships in Androgens Anabolic Androgenic 17a-methyl Testosterone 1 1 (oral) Fluoxymesterone 1 1 (oral)

Structure Activity Relationships in Androgens Anabolic Androgenic Nandrolone 2.5 1 (injectable) Oxymetholone 2.5 1 (oral)

Structure Activity Relationships in Androgens Anabolic Androgenic Stanozolol 3 1 (oral) Dromostanolone 4 1 (oral)

Structure Activity Relationships in Androgens 17a-methyl testosterone (10-50 mg/day) Ethylestrenol (4 mg/day) Oxandrolone (5-10 mg/day) Methenolone acetate (20 mg /wk) Norethandrolone 10-30 mg/day Chlorotestosterone acetate (20 mg / wk)

Androgens Antagonists Danazol (endometriosis) Finesteride (baldness) Bicalutamide (prostate cancer) Flutamide (prostate cancer)