1. Estrogenic Steroids Overall Organization of the Topic
Structure and nomenclature of natural estrogens
- Estradiol, estrone, and estriol
Biosynthesis and metabolism of estradiol
Synthetic estrogens
- Schuler’s hypothesis
Estrogen antagonists
- clomiphene and tamoxifen
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MEDC 603 Steroids

2. Estrogenic Steroids Structure and Nomenclature of Natural Estrogens
Estradioll Estrone Estriol
intramuscular intramuscular oral
100% % %
estr-1,3,5-triene-
3,17b-diol
3-hydroxy-estr-1,3,5
-triene-17-one
estr-1,3,5-triene-
3,16a,17b-triol
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MEDC 603 Steroids

3. Biosynthesis and Metabolism of Estradiol
cholesterol pregnenolone testosterone
estriol estrone estradiol
conjugation to glucuronides, sulfates, etc….
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MEDC 603 Steroids

4. Synthetic Estrogenic ethinyl-estradiol diethylstilbestrol
chlorotrianisene dienestrol
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MEDC 603 Steroids

5. Synthetic Estrogenic Schuler’s Hypothesis for Synthetic Estrogens
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6. Synthetic Estrogenic
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7. Estrogen Antagonists chlorotrianisene clomiphene
(estrogenic) (anti-estrogenic)
tamoxifen
(anti-estrogenic)
8/5/2019
MEDC 603 Steroids