Infection of parasite nematodes confounds vaccination efficacy (Urban et al. 2007) Journal Club of Veterinary Medicine, 18 October 2007.

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Presentation transcript:

Infection of parasite nematodes confounds vaccination efficacy (Urban et al. 2007) Journal Club of Veterinary Medicine, 18 October 2007

If you want to be innovative? The get rid of the laid back attitude! It has to hurt a little to participate in an innovation project. If it is too fun and cozy, it does not move, concludes a ph.d.-dissertation. Ingeniøren, 13 October 2007

Immune System

Adaptive Immune System

T-cell development

Cytokines can prime of T helper cells development INF  IL12 TNF  IL4 IL13 IL10 Th0 Th1 Th2 IntracellularExtracellular

“Infection of parasite nematodes confounds vaccination efficacy” (Urban et al. 2007) Veterinary Parasitology August 19; 148(1): Vaccination Cytokines Antibodies (IgG1, IgG2) Challenge (2nd vaccination) General vaccination strategy

“Infection of parasite nematodes confounds vaccination efficacy” (Urban et al. 2007) Veterinary Parasitology August 19; 148(1): VaccinationChallenge (2nd vaccination) + Nematode Heligomosomoides polygyrus Plasmodium yoelii (malaria antigen, mice) IL3 IL4 IL5 IL9 IL13 IgG1 & IgE INF  IL4 IL13 IL10 TGF  Mouse model

“Infection of parasite nematodes confounds vaccination efficacy” (Urban et al. 2007) Veterinary Parasitology August 19; 148(1): NematodeVaccinationChallenge (2nd vaccination) Ascaris suumMycoplasma hyopneumonia (commercial killed vaccine) + Weak Th1 (lungs) Th2 (intestine) 33% specific antibody response to M. Hyopnemonia. Serum conversion did not exceed 78 %. More lung pathology Pig model

Parasitic infections as medicine Chron’s Disease (regional interitis) An inflammatory bowel disease Th1-dominated Autoimmune disease Th2

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