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Figure 1 Protective effects of acellular pertussis vaccines (A–F) in the respiratory infection model. Mice were challenged by exposure to an aerosol of.

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Presentation on theme: "Figure 1 Protective effects of acellular pertussis vaccines (A–F) in the respiratory infection model. Mice were challenged by exposure to an aerosol of."— Presentation transcript:

1 Figure 1 Protective effects of acellular pertussis vaccines (A–F) in the respiratory infection model. Mice were challenged by exposure to an aerosol of B. pertussis strain 18–323. Mouse lungs were removed 14 days after the challenge and bacteria in the lungs were counted. Results are presented as CFU, and are mean values per lung, as estimated from individual lungs of five mice. STD, standard pertussis vaccine (whole-cell pertussis vaccine). Each column with a vertical line represents a mean and standard error. *P<0.05 versus the control group. From: Evaluation of efficacy in terms of antibody levels and cell-mediated immunity of acellular pertussis vaccines in a murine model of respiratory infection FEMS Immunol Med Microbiol. 2002;33(3): doi: /j X.2002.tb00594.x FEMS Immunol Med Microbiol | © 2002 Federation of European Microbiological Societies.

2 Figure 2 Protective effects of acellular pertussis vaccines in the intracerebral challenge model. Mice were challenged, 21 days after immunization, with B. pertussis strain 18–323 which was introduced intracerebrally. The mice were observed for 14 days (see Section 2 for details). STD, standard pertussis vaccine (whole-cell pertussis vaccine). From: Evaluation of efficacy in terms of antibody levels and cell-mediated immunity of acellular pertussis vaccines in a murine model of respiratory infection FEMS Immunol Med Microbiol. 2002;33(3): doi: /j X.2002.tb00594.x FEMS Immunol Med Microbiol | © 2002 Federation of European Microbiological Societies.

3 Figure 3 Correlation between clearance of bacteria from the lungs after aerosol challenge of immunized mice (one immunization) and the potency of vaccines as determined by i.c. challenge. From: Evaluation of efficacy in terms of antibody levels and cell-mediated immunity of acellular pertussis vaccines in a murine model of respiratory infection FEMS Immunol Med Microbiol. 2002;33(3): doi: /j X.2002.tb00594.x FEMS Immunol Med Microbiol | © 2002 Federation of European Microbiological Societies.

4 Figure 4 Levels of antigen-specific IgG in the serum of immunized mice
Figure 4 Levels of antigen-specific IgG in the serum of immunized mice. Sera from control mice (Saline) and immunized mice (A–F and STD) were examined by ELISA. Levels of antibodies (anti-PT, anti-FHA, anti-PRN and anti-Fim) were expressed as EU ml<sup>−1</sup>. Each column with a vertical line represents the mean and standard error of results from individual samples of serum from five mice in each group. STD, standard pertussis vaccine (whole-cell pertussis vaccine). From: Evaluation of efficacy in terms of antibody levels and cell-mediated immunity of acellular pertussis vaccines in a murine model of respiratory infection FEMS Immunol Med Microbiol. 2002;33(3): doi: /j X.2002.tb00594.x FEMS Immunol Med Microbiol | © 2002 Federation of European Microbiological Societies.

5 Figure 5 Secretion of IFN-γ by spleen cells in vitro in response to vaccine components as antigens. Spleen cells were prepared from control mice (Saline) and immunized mice (A–F and STD). The results represent mean concentrations of IFN-γ, as estimated from individual cultures of spleen cells from five mice in each group. Each column with a vertical line represents a mean and standard error of results from individual samples of spleen cells from five mice in each group. STD, standard pertussis vaccine (whole-cell pertussis vaccine). From: Evaluation of efficacy in terms of antibody levels and cell-mediated immunity of acellular pertussis vaccines in a murine model of respiratory infection FEMS Immunol Med Microbiol. 2002;33(3): doi: /j X.2002.tb00594.x FEMS Immunol Med Microbiol | © 2002 Federation of European Microbiological Societies.

6 Figure 6 Secretion of IL-4 by spleen cells in vitro in response to vaccine components as antigens. See legend to Fig. 5 for details. From: Evaluation of efficacy in terms of antibody levels and cell-mediated immunity of acellular pertussis vaccines in a murine model of respiratory infection FEMS Immunol Med Microbiol. 2002;33(3): doi: /j X.2002.tb00594.x FEMS Immunol Med Microbiol | © 2002 Federation of European Microbiological Societies.

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