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11/6/1906, presenile dementia ; amyloid plaques and neurofibrillary tanglesamyloid neurofibrillary tangles Auguste Deter Alzheimer’s Disease

Hippocampus CA: cornu ammonis (horn shape) Alzheimer’s disease

 -amyloid precursor protein (APP) and its principal metabolic derivatives

Treatment for Alzheimer’s Disease Designed helical peptide inhibitor of  and/or  -secretase

2D-SDS-PAGE kDa pH 7 A B C D EF G H Vision Research Lab: Srinivas Sripathi/Welue He/Cameron Atkinson