Production of Beta-amyloid APP binds to brain cell
Production of Beta-amyloid Enzymes cut APP molecule and release Beta-amyloid
Production of Beta-amyloid Beta-amyloid conglumerates
What Are Neuritic Plaques? Extracellular abnormalities involving the accumulation of beta/A4-amyloid. Beta/A4-amyloid derives from amyloid precursor protein (APP). Abnormal degradation of this protein produces peptide fragments which aggregate into insoluble beta/A4-amyloid.
What Are Neuritic Plaques? Spherical in structure measuring about 0.2 millimeters in diameter
What Are Neuritic Plaques? Often found adjacent to capillaries and large blood vessels. Generally found on the surface of cerebral cortex. Can be found in other regions of the brain. (i.e. hypothalamus, cerebeller cortex, pons, etc.)
Production of Tangles Normal microtubules have stabilizing tau molecules. Diseased microtubules degrade and release the tau molecules which form tangles.
What Are Neurofibrillary Tangles? Twisted nerve cell fibers made up of damaged remains of microtubules. Tau proteins promote microtubule stability. Tau proteins become hyperphosphorylated. Abnormal tau protein binding causes microtubule breakdown and the tau protein clump to form neurofibrillary tangles.
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