PDG-PET/CT vs MRI: diagnostic value for spondylodiscitis Retrospective study ( ): N=70 pts with a clinical suspicion of spondylodiscitis or an infection or fever of unknown origin, undergoing 18 F-fluorodeoxyglucose (FDG) PET/CT + contrast-enhanced MRI of the spine within ≤ 2 wk Exclusion criteria: MRI or FDG-PET/CT ≤6 wk after spinal surgery; known final fracture; no final clinical diagnosis Final clinical diagnosis of spondylodiscitis: 50/70 pts (71%): –Based on positive cultures of blood and/or tissue + imaging suggestive of spondylodiscitis: 94% –Based on imaging suggestive of spondylodiscitis + response to antibiotic Tx: 6% Smids C. ECCMID 2014 abs. eP227 1 of 2 Data from poster

PDG-PET/CT vs MRI: diagnostic value for spondylodiscitis Compared with MRI, FDG-PET/CT has a superior diagnostic value for detecting early (<2 wk) spondylodiscitis and a higher sensitivity for detecting paravertebral and psoas abscesses Smids C. ECCMID 2014 abs. eP227 2 of 2 Data from poster

Antibiotic treatment (Tx) for vertebral osteomyelitis (VO) Multi-centre, non-inferiority RCT: N=351 pts with VO (mean age: 61 yr; 69% male): 6 weeks antibiotic Tx vs 12 weeks antibiotic Tx Most frequently prescribed antibiotics: –For S. aureus: rifampicin (87.6%), fluoroquinolones (83.4%), methicillin (75.9%), aminoglycosides (74.5%) –For Streptococcus spp: aminopenicillin (92.1%) –For IE: aminoglycosides (80.4%), aminopenicillin (50%) –Combination therapy: fluoroquinolones + rifampicin (79.1%) Dinh A. ECCMID 2014 abs. O258 1 of 2

Antibiotic treatment (Tx) for vertebral osteomyelitis (VO) Median duration of iv antibiotic Tx: 20.8 days Intolerance to antibiotic Tx: N=29 Vancomycin: responsible for 21.1% of adverse events 6 weeks antibiotic Tx for VO seems to be non-inferior to 12 weeks Tx Dinh A. ECCMID 2014 abs. O258 2 of 2