Augmentation of Alveolar Bone and Dental Implant Osseointegration: Clinical Implications of Studies with rhBMP-2 by Ulf M.E. Wikesjö, Rachel G. Sorensen,

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Augmentation of Alveolar Bone and Dental Implant Osseointegration: Clinical Implications of Studies with rhBMP-2 by Ulf M.E. Wikesjö, Rachel G. Sorensen, and John M. Wozney J Bone Joint Surg Am Volume 83(1 suppl 2):S136-S145 April 1, 2001 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 1 For the critical-size supraalveolar periodontal defect model (a), the crowns of the third and fourth mandibular premolar teeth in the dog have been reduced in height to just above the crown margin. Ulf M.E. Wikesjö et al. J Bone Joint Surg Am 2001;83:S136- S145 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 2 Representative photomicrographs at 8 weeks after surgery from the critical-size supraalveolar periodontal defect model implanted with recombinant human bone morphogenetic protein-2 (rhBMP-2) in (a) bovine bone mineral matrix (Bio-Oss; Osteohealth);... Ulf M.E. Wikesjö et al. J Bone Joint Surg Am 2001;83:S136- S145 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 3 Photomicrographs at 16 weeks after surgery from the critical-size supraalveolar peri- implant defect model implanted with (a) recombinant human bone morphogenetic protein-2 (rhBMP-2/ACS); (b) ACS alone; (c) allogeneic, freeze-dried, decalcified bone... Ulf M.E. Wikesjö et al. J Bone Joint Surg Am 2001;83:S136- S145 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 4 Intrasurgery view of a recombinant human bone morphogenetic protein-2 (rhBMP)- 2/decalcified bone matrix (DBM) onlay in the edentulous posterior mandible (a). Ulf M.E. Wikesjö et al. J Bone Joint Surg Am 2001;83:S136- S145 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 5 Computerized tomography (CT) scan before surgery of the maxillary sinuses in a cynomolgus monkey (a). Ulf M.E. Wikesjö et al. J Bone Joint Surg Am 2001;83:S136- S145 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 6 Clinical view following surgical exposure and debridement of peri-implant defects (a). Ulf M.E. Wikesjö et al. J Bone Joint Surg Am 2001;83:S136- S145 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 7 Prosthetically reconstructed dental implants placed into recombinant human bone morphogenetic protein-2 (rhBMP-2)/ACS-induced and into native resident bone in the dog (a). Ulf M.E. Wikesjö et al. J Bone Joint Surg Am 2001;83:S136- S145 ©2001 by The Journal of Bone and Joint Surgery, Inc.