Clinical assessment of Lymph node 1- History 2-Character of nodal enlargement 3-Associated symptoms 4-Physical Examination 5-Lab investigation

Cause of Lymphodenopathy 1- Infection Bacterial Chlamydia Viral Protozoan Fungal 2-Immunological 3-Malignant

Bacterial infection cause lymphodenopathy Tonsillitis ( Cervical lymph-node ) Syphilis ( inguinal in primary ), ( general in scondary ) Tuberculosis ( human or bovine) Brucellosis Atypical mycobacterial infections

Chlamydia infection cause lymphodenopathy 1- Cat-scratch fever 2- Lymphogranuloma venereum

Viral infection cause lymphodenopathy 1- Epstein Barr virus 2-Cytomegalovirus 3- Infectious hepatitis 4- Rubella 5-Meales 6- HIV

Fungal infection cause lymphodenopathy Histoplasmosis Toxoplasmosis Protozoen infection cause lymphodenopathy

Immunological cause lymphodenopathy 1- SLE 2- Rheumatoid arthritis 3- Sarcoidosis 4-Thyrotoxicosis

Causes of Splenomagaly - Infection : Viral : EBV,CMV, hapatitis Bacterial : SBE, Milliary T.B. Toxo. …………… ……………………………………………………………………………………………………… Salmpnela, Brucella Protozoal: Malaria, Toxo. Leishmaniasis - Hemolytic : Congenital Aquired - Myeloprolifrative - Lymphoprolifrative - Autoimmune disorders - Storage disorders - Congestion - Metastases

Criteria for B symptoms Criteria for B symptoms : B symptoms generally correlate with advanced stage and bulk disease. Specific B symptoms are defined as follows: 1- Unexplained weight loss of more than 10 percent of body weight during the six months before initial staging investigation 2- Unexplained persistent or recurrent fever with temperatures above 38 ؛ C during the previous month 3- Recurrent drenching night sweats during the previous month.

اعمال طحال اعمال طحال 1-Filtration 2-Immunologic 3-Reservoir 4-hematopoietic