Liposomes: Formation, preparation, properties and applications

Slides:

Advertisements

Similar presentations

LIPIDIC NANOSTRUCTURES AS CARRIERS FOR CONTROLLED DRUG DELIVERY

Advertisements

NIOSOMeS SRAVANTHI.B INDUSTRIAL PHARMACY.

A. Laouini 1, 2, C. Charcosset 2, R. G. Holdich 1, G.T. Vladisavljevic 1 Investigation of the Preparation of Monodispersed Liposome Suspensions Using Microsieve.

Ophthalmic products definition requirements types of additives

Nanomedicines for diagnosis and therapy. Nanomedicines.

Colloid & Surface Phenomena Loition Jason Ashbery Jonathan Danner Haohao Huang Leigh Vorreuter.

SURFACTANTS IN SOLUTION. Amphiphilic Surfactants Amphiphilic surfactants contain a non-polar portion and a polar portion. Aerosol OT.

Introduction to Controlled Drug Delivery Corinne Lengsfeld Department of Engineering University of Denver

NUR HIDAYAH OMAR SITI HAJAR ABU BAKAR ALIA ZULAIKHA MOHD HANIF NUR HIDAYAH OMAR SITI HAJAR ABU BAKAR ALIA ZULAIKHA MOHD HANIF.

Drug Delivery and Mass Balance BIOE201-B. The concentration of the drug at the site of action, over time. Drug delivery is about the complex mechanisms.

Pharmacokinetics Chapter 4.

Roselyn Aperocho-Naranjo Pharmacy Instructor USPF, College of Pharmacy

Methods For Monitoring Transdermal Drug Delivery Analytical/Radio/Nuclear (ARN) Seminar Jivan Yewle Department of Chemistry University of Kentucky.

Morphological Changes of Liposomes Induced by Melittin Jirun Sun Full Talk for Macromolecules Seminar J, Dufourcq et al., BBA 859, 1986, 33.

Curcumin, the constituent of Curcuma longa, is considered a very promising anticancer agent due to its potent and pleiotropic antineoplastic activity and.

From the results it´s clear that anovel nanoparticle drug-polymer conjugate has been synthesized with suitable properties for light activated therapy.

Biomass Fundamentals Modules 19: Higher Order Functionality in Biomass: Surface Active Materials A capstone course for BioSUCCEED: Bioproducts Sustainability:

Methods of Drug Delivery

IPTC workshop in China Mahn Won Kim (1), Joon Heon Kim (1,2) (1) Dept. of Physics, KAIST, (2) APRI, GIST Adsorption and Transport of a Small Molecule on.

.  Based on particle size and surface charge characterization studies, both nanoparticles have successfully been synthesized.  Successful conjugation.

NANOTECHNOLOGIES: THE NEW GENERATION OF MEDICINE Dr Mariano Licciardi.

Liquid Crystal in Cosmetics emulsions

Liposomes The liposome was adopted as a promising delivery system because its organized structure which could hold drugs, depending on their solubility.

Liposomes Dr. Aws Alshamsan Department of Pharmaceutics Office: AA87 Tel:

Liposome Drug Products: Chemistry Manufacturing and Control Issues Arthur B. Shaw, Ph.D. Office of New Drug Chemistry Division of New Drug Chemistry II.

The Cell Membrane Write. Cell Membrane The membrane of the cell has many different names. You may hear it called: The phospholipid bilayer The semi-permeable.

Cell Membrane. Cell Membrane? Location?  Surrounding the cell Function? 1.Protection and support for the cell 2.Regulation of what enters and exits the.

Polymeric Micelles Dr. Aws Alshamsan Department of Pharmaceutics Office: AA87 Tel:

Mastic is a well-known natural resin from the trunk and branches, of Pistacia lentiscus var. chia (Anacardiaceae), which is grown as endemic only in the.

Burgess, June 28, REGULATORY SCIENCE OF LIPOSOME DRUG PRODUCTS Diane J. Burgess, Ph.D. Professor of Pharmaceutics University of Connecticut Office.

PHARMACOKINETICS Part 3.

Nanomedicines. Nanomedicines for diagnosis and therapy.

Abstract Polymeric Porous microspheres are an effective drug delivery mechanism able to control drug release, preventing drug wastage and lowering costs.

Concepts in Transepidermal Absorption and Penetration Shawn Schmieder, OMS-IV Parth Patel, MS-III Joke Bouwstra, PhD Karthik Krishnamurthy, DO.

Liposomes are spherical vesicles composed of a membrane surrounding an aqueous core. Liposomes are used for drug delivery (in the form of genes, peptides,

Surfactants Introduction to Liquid Crystals

Commercialization Development of Consumer Products Guerbet Glycosides

Liposomal formulations of anthracyclines By Nortan Hashad Under supervision of Prof. Nashaat Lotfy Professor of oncology.

Investigations of Nanosystems and Novel Materials by Neutron Scattering Methods Theme /2011 Physics of Nanosystems Structure and Dynamics.

Modern aspects of drugs production. Differences.

What is a Liposome? A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane. Liposomes can be filled with drugs, and used.

Tetraether macrocyclic lipid O O O OH OH OH O R 3 CH 3 CH 3 CH 3 CH 3 CH 3 CH 3 O O CH 3 CH 3 CH 3 CH 3 CH 3 CH 3 CH 3 PO 4 R 1 CH 3 OH Liposomes are spherical.

Gene therapy Lecture 8. What is a liposome? ◦ Spherical vesicles with a phospholipid bilayer Hydrophilic Hydrophobic.

PH-Sensitive Liposomes for Effective Release of Therapeutics By: Savita Ramlall Mentor: Professor Sofou & Shrirang Karve Polytechnic University Laboratory.

Plasma Membrane, cell wall and cell surface Course Title: Biochemistry and Molecular Biology Course No. PHR 202 Course Teacher: Shahana Sharmin (SHN)

In 1900, Ehrlich (father of chemotherapy) described his famous side chain theory of antibody formation, proposing that antigens bind to pre-existing side.

Pharmacokienetic Principles (2): Distribution of Drugs

Membrane Transport and Function

LIPOSOMES AS DRUG CARRIERS

BTY100-Lec 2.3 Nanobiotechnology.

The Chemistry of Consumer Products Topic 2

DNA-MEMBRANE RECOGNITIONS: FROM PROTOCELL EVOLUTION TO BIONANOTHERAPY

MEMBRANE ACTIVITY.

Self emulsifying Drug Delivery System : Formulation

Organic nanoparticles Inorganic nanoparticles

Volume 93, Issue 1, Pages (July 2007)

Liposome Applications —Creative Biostructure. Creative Biostructure established an advanced and novel Liposomes Platform to faciliate research in membrane.

Non-PEGylated Liposome Production Non-PEGylated Liposome Production —Creative Biostructure.

Volume 93, Issue 5, Pages (September 2007)

Reversible Liposome Association Induced by LAH4: A Peptide with Potent Antimicrobial and Nucleic Acid Transfection Activities Arnaud Marquette, Bernard.

Pharmaceutical Technology

Modified Fullerene Vesicles and Membranes,

2.4 Membrane Structure.

Introduction to Pharmacology

Hemin J Majeed MSc. Pharmaceutical sciences

Thermodynamic Profiling of Peptide Membrane Interactions by Isothermal Titration Calorimetry: A Search for Pores and Micelles J.R. Henriksen, T.L. Andresen

Self-assembly in Nature

Volume 74, Issue 6, Pages (June 1998)

2016 Enhanced Synthesis and Purification of PEGylated Liposomes for Targeted Drug Delivery Neil Parikh, Steven Roberts, and Nitin Agrawal

Presentation transcript:

Liposomes: Formation, preparation, properties and applications Dr. S.S.Apte Professor, Univ. College of Pharm. Sci., Kakatiya University, Warangal Presently: NDDS Divn, Natco Research Centre Hyderabad

Liposomal Anthracycline Antibiotics Used in Therapy Product Drug Marketed By Registration Year DaunoXome Daunorubicin citrate NeXstar Pharmaceutical Inc. England Sweden USA 1995 r. 1995 r. 1996 r. Doxil Doxorubicin Sequus Pharmaceutical Inc. USA 1995 Caelix Schering-Plough Selected European Countries 1995 r.

Definition of Liposomes Liposomes are spherical, self closed structures composed of curved lipid bilayers which entrap part of the solvent, in which they freely float, into their interior. They may consist of one or several concentric membranes; their size ranges from 20 nm to several dozens µm, while thickness of the membrane is around 4 nm.

Salient features Discovered in 1968 by Alec Bangham Delivery system for hydrophilic, lipophilic, and amphiphilic APIs Solubilization of lipophilic and amphiphilic APIs Protection of the API Reduction of side effects - toxicity of the active Sustained release Drug targeting Low application dose

Classification of Liposomes SUV = Small Unilamellar Vesicles LUV = Large Unilamellar Vesicles MLV = Multilamellar Vesicles LLC = Lamellar Liquid Crystalline Phase MVV = Multivesicular vesicles Liposomes are composed of one to several hundreds concentric membranes

liposomes (phospholipids + Cholesterol) Vesicular delivery systems liposomes (phospholipids + Cholesterol) Vesicles Niosomes (Nonionic surfactants +cholesterol)

Preparation of vesicles: Film casting via organic solvent film hydration ether-ethanol injection Reverse phase evaporation Through mixed micellar solution Mechanical methods

Characterization of vesicles: Size and size distribution - Dynamic light scattering Electron microscopy Coulter counter Number of lamellae - NMR spectroscopy small angle X ray scatter Charge - Microelectrophoresis Entrapment efficiency - Gel filtration Capture volume - ultrafiltration dialysis protamine aggregation ultracentrifugation Release - Dialysis

Liposomal Delivery of Anti-Cancer Agents Slow Release: reduced peak levels of free drug and prolonged tumor exposure Change in Biodistribution: avoiding drug deposition in certain tissues will reduce tissue-specific toxicities Tumor Targeting: passive accumulation by enhanced permeability and retention (EPR) effect

Phospholipids in topical pharmaceutical applications Drug Effects Benzoyl peroxide Flurbiprofen Diclofenac Heparin Clindamycin phosphate Aciclovir Menthol & camphor N,N-diethyl-meta-toluamide (DEET) Povidone-Iodine Tamoxifen Econazol, Miconazol Glycolic acid Bethametasone 17-benzoate improved drug delivery; higher anti-bacterial efficacy better penetration; improved efficacy in pain treatment improved drug delivery; higher drug efficacy improved penetration; higher drug efficacy sustained release, drug efficacy improvement enhanced penetration enhanced penetration, rapid onset of action controlled release, inhibition of absorption improved drug delivery & efficacy improved penetration and drug retention in the skin drug retention in the skin controlled release penetration enhancement