Biological Properties ISSUES TO ADDRESS... Biomaterials definition Different types of interaction between body and foreign material What are main characteristics of a biomaterial Types of biomaterials Applications of biomaterials
Biomaterials Definition A multidisciplinary knowledge of studying materials behavior in the body environment Any material, natural or synthetic, that comprises whole or part of a living structure or a biomedical device which performs, enhances, or replace a function that has been lost through disease or injury
Different types of interaction between body and foreign material ExampleResultType of foreign material Most of the MetalsTissues deathToxic Most of the Ceramics like Alumina and Zirconia Fibrous tissue formationNearly Inert Hydroxyapatite, BioglassSurface-tissue interaction at the interface Bioactive Tricalcium phosphate, Collagen Substitution of material whit tissue Degradable
What are main characteristics of a biomaterial? Biocompatibility Mechanical properties Properties regarding to application
Different types of biomaterials
CeramicPolymerMetalProperty High Mostly bioactive and non-toxic Intermediate Can be toxic Low Toxic productsBiocompatibility LowintermediateHighMechanical LowHighintermediateProcessability
Classification of application of materials in Biomedical Engineering Implants and tissue replacement Tissue Engineering Drug delivery systems Biosensors and medical diagnosis
Implants and tissue replacement Body Biomaterial Fibrosis encapsulation Protein attachment Coagulation Mechanical degradation and erosion Undesirable immunological response Biomaterial rejection
Biocompatibility Biocompatibility is the ability of the materials to perform in the presence of an appropriate host for a specific application. Titanium and titanium alloys (Thin surface oxide) Relatively inert good corrosion resistance
Cardiovascular substitutes: Artificial heart valves Heart Function : pumping blood to all parts of body Entrance and outgoing of blood into ventricle heart is occurring in heart valves -Tricuspid valve - Pulmonary valve - Mitral valve - Aortic valve
Types of Artificial Heart Valves Natural substitutes (Bioprosthetic Heart Valves) -High biocompatibility and blood compability -Shorter life-time -Grafting problems like out break of disease Artificial substitutes (Mechanical Heart Valves) -Longer life-time -Stronger mechanical properties -Can be lead to coagulation
Skin Tissue Engineering
Nerve repair
Injectable Scaffolds (Insitu forming)
Cell Source 1.Autologous cells 2.Allogenic cells Primary cells Cell-Lines Stem cells
Drug Delivery Systems Delivering drug or any other biological agent to a specific part of patients body with the control of the dosage Advantages: – Increasing drugs effectiveness – Preventing from toxic dosages – Decreasing side effects – Preventing drug loss – Controlling drug behavior – Probability of targeted and prolonged release
Biosensors The term ‘‘biosensor’’ is used to cover sensor devices in order to determine the concentration of substances and other analytes of biological interest, in some cases even where they do not utilize a biological system directly
Biosensors Physical sensors Optical sensors Pressure sensors Temperature sensors Magnetic sensors Acoustic sensors Chemical sensors Gas sensors Humidity sensors Ionic sensors Biochemical sensors Biosensors
Sensors compared with sense organs of man: - Optical sensors- eyesight - Gas sensors- olfaction - Sensors for pressure, temperature-touch - Acoustic sensors- hearing - Chemical sensors- taste
Materials for biosensors Synthetic polymers Hydrogels Natural polymers Biological materials CeramicsMetals Biological tissues
Piezoelectric Sensors
Bioceramics Calcium phosphates: hydroxyapatite, tricalcium phosphate Alumina Zirconia Glass-Ceramics Bioglass Clays and LDHs( Layered Double Hydroxide) Ferromagnetic bioceramics Carbons
Types of bioceramics applicationStructureForms Filler, tissue regeneration and repair Polycrystalline Amorphous Powder and granules Tissue bonding, anti- coagulation, anti-corrosion Polycrystalline Amorphous Semi-Crystal Coat Tissue regeneration and replacement Single crystal Polycrystalline Amorphous Composite Body
Bioceramics advantages over other materials Consisting of elements similar to body physiological environment like: Ca, K, P, Na and Mg Products of mechanical degradation and chemical dissolution are inert and can be adsorbed through body metabolism Strong ionic and covalent bonds and lack of free electrons prevent formation of electrochemical cell
Types of Bioceramics Nearly Inert Bioactive Resorbable Porous
Bioceramics applications Orthopedic implants Dental implants Grafts and substitutes Hypodermic devices Ear implants Contact lens Artificial heart valves