Daily fMRI Practice John Li MD 9/27/2012. When you preparing a fMRI study, you need to Read and understand the fMRI requirements. Design and choose proper.

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Presentation transcript:

Daily fMRI Practice John Li MD 9/27/2012

When you preparing a fMRI study, you need to Read and understand the fMRI requirements. Design and choose proper paradigms. Choose the right coil, right gradient and sequences to acquire fMRI data. Choose proper methods to minimize motion.

Daily fMRI Practice Mainly Involve Follow Modules Data Acquisition Paradigm Post Processing Result Interpretation Experiment Design

Designs for fMRI Data Acquisition Block Design Event Related Design Resting State

Paradigms Good Design Careful Selection Proper Delivery

Good Paradigm Performance Needs Good instruction, correct understanding of paradigm, good performance of paradigm. Close observation of subject performing paradigm. Properly reminding the subjects about the coming steps

Checkerboard is one Well-Known Paradigm Visual Stimulus Block Design

Baboon’s Visual and Motor Activation Results Wey HY, Li J, Szabo CA, Fox PT, Leland MM, Jones L, Duong TQ. Neuroimage Oct 1;52(4):1420-7

Different Frequency Will Stimulate Visual Cortex Differently

The Visual Cortex Activation Area will be Different with Different Designs of Checkerboards Targeting Different Parts of Visual Field Full Visual Field

Human Bilateral Finger Tapping Sequence fMRI Result Thanks to Crystal Franklin for the picture.

Flashing Light and Tactile Stimulator On Vibration Off

Example:Multi-surface Wooden Ball and Multi-grades Sand Paper Stimulus and Design

Example Results Gao JH, Parsons LM, Bower JM, Xiong JH, Li JQ, Fox PT (1996): Cerebellum implicated in sensory acquisition and discrimination rather than motor control. Science 272:

Psychological Paradigms N-back, Gambling, Shape-Matching, Face-Matching, Stroop…

Visual Cue for Subject to Adjust the Squeeze Force Rest Squeeze 3 min

Adjustable Weight Load Pressured Air for Removing Weight Load Stopper 20°

Eccentric vs. Concentric Muscle Contraction in First Dorsal Interosseus

Coil Selection Any coil can be used in fMRI studies. When using GRAPPA or mSENSE, phased array coils are required. T/R Head Coil 12 Channel Phased Array Coil

With Insert Gradient, High Resolution fMRI And Shorter TE Will be Possible

TSE Segmented EPI Conventional GRE Single Shot EPI Comparison of Different Pulse Sequences Used in fMRI

Reducing Motion is One of the Keys for a Successful fMRI

Reducing Motion is One of the Keys to fMRI Success

Baboon Head Holder

Activation pattern in ASL with 2x2x5 300ml TRUTOL 75 (Glucose Tolerance Beverage) 300ml Water

Hypothalamus Motion related areas Motion artifact shares similar activation pattern Thanks Claudia Huerta for Data Analysis

Adjusting Scan Parameters TR, TE & flip angle Field of view, resolution & matrix size Slice thickness & gap between slices Number of slices & slice acquisition order Receiver bandwidth & echo train space

GRAPPA and mSENSE When you choose parallel imaging technique GRAPPA or mSENSE, you can get more slices for a given TR.

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Supplementing MRA with fMRI MR Angiography Demonstrates an AVM (Arteriovenous Malformation) Yellow Arrow: Supply Artery Blue Arrow: AVM Red Arrow: Drain Vein

Interpretation of fMRI Results T2 Axial Images T1 Axial ImagesAVM

Interpretation of fMRI Results Verb Generation from Noun Verb Generation from Picture Language Center Is Dominant in the Left Hemisphere Thank to Crystal Franklin for the pictures.

Thanks!