VARIATION OF LEUKOCYTES IN DISEASE Neutrophilia PMN> Neutropenia mild PMN< moderate PMN< SEVER PMN< 500 EOSINOPHILA EOS> 700 OR > 200 BASOPHILIA BAS>150 OR >100 MONOCYTOSIS MON>950 LYMPHOCYTOSIS LYM> 4000 LYMPHOCYTOPENIA LYM< 1500 DR F. MOKARIANDR F. MOKARIAN LEUKOCYTOSIS>10000 LEKOPENIA<4000

VARIATION OF LEUKOCYTES IN DISEASE CAUSES OF NEUTROPHILIA Acute infection Other inflammation : burn operation MI gout CVD HYPERSENCITYVITY Intoxication : Metabolic: DKA PERICARDITIS IN UREMIA ECLAMCIA Poisoning by chemical and drugs Acute hemorrhage Acute hemolysis Malignant neuplasms Physiologic neutropenia MPD Others: CIN HN Corton G CSF DR F. MOKARIANDR F. MOKARIAN

VARIATION OF LEUKOCYTES IN DISEASE CAUSES OF NEUTROPENIA Pseudoneutropenia Acquired neut Drugs And Chemicals Neutritional Immune Neut Felty syn Neut. Associated With Complement Activation Congenital Or Chronic Neut DR F.MOKARIANDR F.MOKARIAN

VARIATION OF LEUKOCYTES IN DISEASE CAUSES OF : BASOPHILIA BASOPHILOPENIA MYXEDEMA HYPERTHYROIDISM ULCERATIVE COLITIS OVULATION CHRONIC SINISITIS PREGNANCY SMALLPPOX STRESS VARICELLA NEPHROSIS IDA LUNG CACER CML PV MF HD HEMOLYTIC ANMIA DR F. MOKARIANDR F. MOKARIAN

CAUSES OF EOSINOPHILAI Allergic disorder Skin dis Parasitic Infection Loeffler’s Syn PIE syn Tropical Eosinophilia Certain Infection Malignant disease of any type ( metastasis or necrosis ) Hematological dis : HD CML PV PA SPLENECTOMY IRRADIATION INHERITED IDIOPATIC OTHERS: RA PAN SARCO POISEN DR F. MOKARIANDR F. MOKARIAN

VARIATION OF LEUKOCYTES IN DISEASE CAUSES OF MONOCYTOSIS CERTAIN BACTERIAL INFECTION TB SBE SYPHILIS BRUCELOSIS DURING RECOVERY FROM ACUTE INFECTION AND FROM AGRANULOCYTOSIS Protozoal And Ricketsial infextion Malaria typhose rocky moun. Spotted fever – kala azar Hematologic malignancy : NHL HD AML MPD MM Malignancy : ovary stomach breast CVD : SLE RA Granulomatous dis :Sarco Ulcerative colitis Regional enteritis Tetracholoroetan poisening Chronic high dose steroid therapy DR F. MOKARIANDR F. MOKARIAN

VARIATION OF LEUKOCYTES IN DISEASE CAUSES OF LYMPHOCYTOSIS Certain Acute Infection Pertosis - inf mono – hepatitis – acute infec. lymphosytosis Certain chronic infection Brucellosis TB syphilis Hematologic disorder ALL CLL HCL NHL NHL PCD Relative lymphocytosis : exanthem inf. After the intial stage : mumps rubella during convalesence from acute infection thyrotoxicosis most condition that associated with neutropenia

VARIATION OF LEUKOCYTES IN DISEASE Causses of lymphocytopenia Acute infection Chronic Illness : CHF Pneumonia Pancreatic necrosis Active TB Uremia NHL HD CVD : SLE AID”S MALARIA STEROID IRRADIATION DR F. MOKARIANDR F. MOKARIAN

VARIATION OF LEUKOCYTES IN DISEASE Diseases most commonly giveng rise to a leukomoid blood picture INFECTION PNEUMONIA MENINGITIS DIFTERIA TB MYLOID LEUKEMIA VARICELLA IM INFEC. LYM, LYMPHOID LEUK Intoxication : eclamsia, sever burns, mercury Malignant dis : bone met MM HD myelofibrosis Sever hemorrhage Acute hemolysis DR F. MOKARIANDR F. MOKARIAN

VARIATION OF LEUKOCYTES IN DISEASE LEKOMOID RECTION : MYLOID LEUKOMOID REACTION LITTLE IMATURITY WITH LEFT SHIFT ( SIMULATE CML) TUMOR & INFECTION SIMULATING AML TB ALCOHOLISM MEGALOBLASTIC ANEMIA LYMPHOID LEUKOMOID REACTION MATURE CELL PERTOSIS DERMATITIS HERPETIFORM VARICCELLA MELLANOMA BREAST CA TB MILLIARY IMMATURE CELL IM HEPATITIS TB CM SYPHILIS DR F. MOKARIANDR F. MOKARIAN