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3 Preface The aim of this atlas is to help the medical students in the reading of blood film for common hematological disorders; and to help them in the understanding of various tools used in the microbiological diagnosis. (cont.) 3

4 Contents 4

5 Blood film : Normal red cells
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6 Blood film : Normal platelets
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7 Blood film : Normal neutrophil
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8 Blood film : Normal lymphocyte
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9 Blood film : Reticulocyte
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10 Nucleated red cells {bone marrow irritation}
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11 Microcytes {IDA, Thalassemia, lead poisoning}
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12 Macrocytes {megaloblastic anemia, MDS}
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13 Macrocytes with hypersegmented neutrophil (more than 5 segments) {megaloblastic anemia}
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14 Anisocytosis (variable sizes) {non specific caused by many types of anemia}
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15 Poikilocytosis (variable shapes) {non specific caused by many types of anemia}
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16 Sickle cells {sickle cell anemia}
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17 Target cells {hemoglobinpathies, liver disease}
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18 Spherocytes {hereditary spherocytosis and AIHA}
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19 Elliptocytes (oval shape RBC) {hereditary elliptocytosis}
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20 Stomatocytes {hereditary stomatocytosis, alcoholism}
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21 Echinocytes (burr cells) {CRF, in vitro artifact}
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22 Acanthocytes (spur cells) {liver disease, a B- lipoproteinemia}
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23 Schistocytes (Fragmented cells) {traumatic hemolytic anemia: DIC, TTP, prosthetic valve}
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24 Bite cells (blister cells) {G6PD deficiency anemia}
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25 Teardrop cells {myelofibrosis}
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26 Agglutinated red cells {cold agglutinin hemolytic anemia}
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27 Rouleaux formation {multiple myeloma, macroglobulinemia}
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28 Basophilic stippling {hemolysis, lead poisoning}
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29 Heinz bodies (Hb polymers) {hemoglobinpathies, G6PD deficiency}
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30 Howell Jolly bodies (nuclear remnants) {post- splenoectomy}
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31 Lymphoblasts {ALL} 31

32 Myeloblasts {AML} 32

33 Auer rod {AML} 33

34 Leukocytosis with relative lymphocytosis {CLL}
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35 Leukocytosis ranging from myeloblasts to mature neutrophils {CML}
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36 Abnormal lymphocyte {hairy cell leukemia}
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37 Atypical lymphocyte {viral infections, toxoplasmosis, lymphoma}
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38 Increase platelets count {Essential thrombocythemia}
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39 Bone marrow: Ring sideroblast {MDS: refractory anemia with ring sideroblast}
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40 Bone marrow: Predominance of plasma cells {multiple myeloma}
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41 Lymph node biopsy: Reed Sternberg cells {Hodgkin's lymphoma}
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