1 Why is Photostability Important?

2 Biggest Innovation in UVA Protection has Been the Invention of Avobenzone Avobenzone provides broad spectrum beyond 370 nm 290 Wavelength (nm) Absorbance With avobenzone With oxybenzone Data on file, Johnson & Johnson Neutrogena.

3 An Example of Avobenzone Photoinstability in a Sunscreen Formulation Wavelength (nm) Absorbance Static SPF 10 J 20 J 50 J Data on file, Johnson & Johnson Neutrogena.

4 Why is Photostability Important? Photostable and non-photostable spf products have the same protection up to their SPF value, but protection after first MED is very different

5 How Can You Tell Which Ones Are Photostable? Currently, there is no uniform test method or communication device on products to indicate photostability of products or extent of UVA protection

6 Helioplex ™ Technology

7 What Comprises Helioplex ™ Technology? Photostable UVA –Contains avobenzone—provides broad UVA protection –Contains diethylhexyl 2,6-naphthalate (DEHN)— an avobenzone stabilizer –Contains benzophenone (oxybenzone, sulisobenzone, or dioxybenzone)—stabilizes avobenzone and adds UVA protection Added SPF drivers – Conventional UV filters to build SPF Data on file, Johnson & Johnson Neutrogena.

8 Mechanism of Action of Helioplex ™ UV

9 Mechanism of Action of Helioplex ™ UV DEHN UV DEHN UV DEHN UV DEHN

10 Ultraviolet Photography demonstrates the red fluorescence of Helioplex ® Photograph courtesy of Darrell Rigel, MD

11 Neutrogena Now Offers Broad-Spectrum Protection That Is Photostable Wavelength (nm) Neutrogena Ultra Sheer SPF 50+ With Helioplex™ 1.8 Absorbance J 10 J 20 J 30 J 50 J Nonphotostable Sunscreen Data on file, Johnson & Johnson Neutrogena.

12 Photostable in Real Sunlight Neutrogena Ultra Sheer SPF 50+ holds up under sunlight Baseline 1.5 hours of sun Wavelength (nm) Absorbance Data on file, Johnson & Johnson Neutrogena.

13 Photostable in Real Sunlight Neutrogena Ultra Sheer SPF 50+: PFA % ZnO SPF 4: PFA 4 9% TiO 2 SPF 30: PFA Wavelength (nm) Absorbance Data on file, Johnson & Johnson Neutrogena.

14 Photostability of Helioplex ™ Compared With Anthelios SPF 60+ With Mexoryl ® Data on file, Johnson & Johnson Neutrogena. COLIPA n = 5 avg In Vitro Photostability (COLIPA Method) % Loss After 50 J Simulated Exposure Anthelios XL 60+ –15% –39% Neutrogena Ultra Sheer SPF 50+ With Helioplex ™ % Loss

15 Photostable Even Under Direct Tropical Sun Exposure*

16 Helioplex ™ technology offers a step change in protection Helioplex ™ technology offers exceptional and photostable UVA protection – PA +++! –PFA protection values for Helioplex products exceed 20 (PA+++ only requires PFA = 8) Comparable protection to Mexoryl  Anthelios XL 60 technology with better photostability

17 PLE Protection by Ultra Sheer SPF 50+ With Helioplex ™ : Results

18 PLE Protection by Ultra Sheer SPF 50+ With Helioplex ™ : Conclusions Leyden J, et al. Multi-center evaluation of protective benefits of a photostable UVA/UVB sunscreen for polymorphic light eruption. Poster presentation at: American Academy of Dermatology 64th Annual Meeting; March 3-7, 2006; San Francisco, Calif. Percent Agreement Subject Self-Perception Efficacy and Aesthetics Lengthens time outdoors Weightless feeling Is not greasy/oily/tacky Absorbs quickly/evenly Does not sting Is gentle Overall rating (excellent-good)

19 PLE Protection by Ultra Sheer SPF 50+ With Helioplex ™ : Conclusions Complete inhibition of PLE by Ultra Sheer SPF 50+ with Helioplex ™ The aesthetics of Ultra Sheer SPF 50+ with Helioplex ™ was favorably rated by users with PLE; this may enhance compliance with use Leyden J, et al. Multi-center evaluation of protective benefits of a photostable UVA/UVB sunscreen for polymorphic light eruption. Poster presentation at: American Academy of Dermatology 64th Annual Meeting; March 3-7, 2006; San Francisco, Calif.

20 Neutrogena Helioplex Sunscreens Does not leave a film/residue Is not tacky Is not sticky Is not greasy Leaves a velvety skin feel Leaves the skin feeling nourished Data on file, Johnson & Johnson Neutrogena.

21 Sunscreen With Helioplex ™ : Ultra Sheer Aesthetics Unsurpassed Protection Superior Aesthetics and Skinfeel Outstanding Value Dermatologists Preferred for themselves and their families