Periodontal Health and Birth Outcomes Secretary’s Advisory Committee on Infant Mortality – SACIM November 30, 2006 M. Ann Drum, DDS, MPH, Director Department.

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Presentation transcript:

Periodontal Health and Birth Outcomes Secretary’s Advisory Committee on Infant Mortality – SACIM November 30, 2006 M. Ann Drum, DDS, MPH, Director Department of Health and Human Services Health Resources and Services Administration (HRSA) Maternal and Child Health Bureau (MCHB) Division of Research, Training and Education

In 2003, the U.S. Surgeon General called for increased attention to oral health education and care during pregnancy as an important strategy for improving maternal and infant health

In 2004, MCHB convened a group of perinatal and oral health experts in science, program and policy Private and public sector

Studies over the last several years have identified periodontal disease as a possible risk factor for pre-term and low birth weight

Periodontal disease may represent: Infectious and inflammatory exposure that has deleterious effects during pregnancy

Periodontal disease is highly prevalent in pregnant women Periodontal disease is preventable and curable

QUESTIONS Is periodontal disease a risk factor for adverse pregnancy outcomes? Will treating periodontal disease in pregnant women prevent adverse pregnancy outcomes? Is the current evidence sufficient to make policy and program changes for peridontal treatment during pregnancy?

British Journal of Obstetrics and Gynecology 2006; 113(2): Periodontal disease and adverse pregnancy outcomes; a systematic review X. Xiong, P. Buekins, W.D. Fraser, J. Beck, S. Offenbacher (25 studies) Since then 19 new studies have been published since March 2005 to date

PROBLEMS Periodontal disease definitions Insufficient sample size Confounding variables Pregnancy outcome definitions

Research to Policy and Practice Forum Research to Policy and Practice: Periodontal Health and Birth Outcomes December 11-12, 2006 Omni Shoreham Washington, D.C.

Meeting Objectives Review current evidence-based research regarding the relationship between periodontal disease in pregnant women and birth outcomes Review current policies, programs, and practices in the public and private sectors addressing the oral health needs of pregnant women, as related to improving birth outcomes and women’s overall health Offer public and private health leaders the opportunity to dialogue about future directions in research, policy programs, and practice related to women’s periodontal health and birth outcomes

Two Background Papers State of the Science Xu Xiong, MD, DrPH Sotirios Vastardis, DDS, MS Pierre Buekins, MD, PhD State of Policy, Program and Practice Burt Edelstein, DDS, MPH Karen VanLandeghem, MPH

Periodontal Disease and Pregnancy Outcomes: State of the Science - 44 studies - Literature search, study selection, data extraction, quality assessment and statistical pooling (meta-analysis) Background Paper #1

New England Journal of Medicine Article, November 2006 Treatment of Periodontal Disease and the Risk of Preterm Birth Bryan S. Michalowicz, DDS, et. al Results - Treatment group - preterm births occurred in 49 of 407 women (12.0%) resulting in 44 live births Control group – preterm births occurred in 52 of 405 women (12.8%) resulting in 38 live births Conclusions - Treatment of periodontitis in pregnant women improves periodontal disease and is safe but does not significantly alter rates of preterm birth, low birth weight, or fetal growth restriction.

Major NIDCR Study to come MOTOR – Maternal Oral Therapy to Reduce Obstetric Risk - S. Offenbacher, UNC 5 year randomized, 2 armed clinical trial 1800 mothers sample size Enrollment to be completed months Hypothesis: Mothers with periodontitis that receive periodontal treatment during 2 nd trimester will experience a lower rate of preterm delivery and a higher mean birth weight of pre-mature infants

Background Paper #2 Public and Private – sector Efforts to Improve the Oral Health of Pregnant Women: Policies, Programs and Practices Overview of current policies, programs and practices Improving birth outcomes as well as women’s overall health

SACIM Invited by MCHB/HRSA to send a representative to the Forum Will receive the 2 background papers on science and policy/program in early December Will receive meeting summary after the forum Will be briefed on Forum findings at the next SACIM meeting