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Oral dydrogesterone treatment during early pregnancy to prevent recurrent pregnancy loss and its role in modulation of cytokine production: a double-blind,

Published byἸωσίας Τρικούπης Modified over 5 years ago

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Presentation on theme: "Oral dydrogesterone treatment during early pregnancy to prevent recurrent pregnancy loss and its role in modulation of cytokine production: a double-blind,"— Presentation transcript:

1 Oral dydrogesterone treatment during early pregnancy to prevent recurrent pregnancy loss and its role in modulation of cytokine production: a double-blind, randomized, parallel, placebo-controlled trial  Ashok Kumar, M.D., Ph.D., Nargis Begum, M.Sc., Ph.D., Sudha Prasad, M.D., Sarita Aggarwal, M.D., Shashi Sharma, Ph.D.  Fertility and Sterility  Volume 102, Issue 5, Pages e3 (November 2014) DOI: /j.fertnstert Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Trial profile showing representative numbers of women in the study. Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

3 Supplemental Figure 1 Cytokine profile of controls and RPL group.
Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

4 Supplemental Figure 2 Percentage change of cytokines (mean ± standard error) in women who had a miscarriage and women who continued the pregnancy beyond 20 weeks of gestation. (A) A statistically significant percentage change of IL-10 level was observed between [1] controls and the placebo group, and [2] controls and the dydrogesterone group. (B) A statistically significant percentage change of IL-4 level was observed between controls and the placebo group. A statistically significant percentage change of IL-10 level was observed between the placebo group and the dydrogesterone group. A statistically significant percentage change of IFN-γ level was observed between [1] controls and the placebo group, and [2] controls and the dydrogesterone group. Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

5 Supplemental Figure 3 Serum cytokine levels (mean ± standard error) at recruitment in the study group with respect to adverse pregnancy outcomes. (A) Serum IL-4 level was significantly higher in preterm delivery and LBW babies in the healthy pregnant control group. (B) Serum IL-10 level was comparable for adverse pregnancy outcomes among the study groups. (C) Serum TNF-α level was significantly higher in preterm delivery in the healthy pregnant control group. (D) Serum IFN-γ was significantly lower in preterm delivery and SFD babies in the placebo group; it was significantly higher in LBW babies in the dydrogesterone group. AFD = appropriate for date; LBW = low birth weight; SFD = small for date. Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

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