MOI-106 Regalia ™ SC (formerly Milsana ® ) Julie Versman, VP Marketing

 Founded 2006 by Pam Marrone, Davis CA  Natural products that focus on unmet needs for weed, pest and plant disease management.  Product discovery from 1) in-house screening 2) in-licensing  A rich pipeline of products in development with applications for specialty crops Marrone Organic Innovations

 Source: Extract from giant knotweed Reynoutria sachalinensis (REYSA).  Formulation: Suspension Concentrate (SC)  Target pathogens controlled (edible crops and ornamentals): Powdery mildew, Gray mold, Rust Bacterial blight, Bacterial canker, Bacterial spot, Target spot, Bacterial speck, Early blight and Late blight of tomato MOI-106 Regalia ™ SC Fungicide Overview

 Mode of Action: Induction of plant defense responses. – 5 x Enzymes of the phenolic pathway – increased production of phytoalexins  Registration status - Has EPA crop and non-crop registrations as biochemical biopesticide. (grapes, cucurbits, strawberries, walnuts, peppers, lettuce, tomato, citrus) - Has California crop and non-crop label (grapes, cucurbits, strawberries, walnuts, peppers, lettuce) Overview continued

MOI-106 Regalia ™ SC - Use/Timing  Apply at the rate of % in 50 to 100 gallons of water per acre.  Add wetting agent at recommended label rate  Use the spray mixture preventatively at the 4-6 leaf plant stage and repeat spraying every 7-14 days depending on disease pressure.  Recommend 0.5% v/v rate in a tank mix with properly labeled rates of Maneb, Mancozeb, or copper products for broad spectrum control of bacterial speck, target spot, tomato late blight and gray mold.

Regalia ™ SC on Food Crops  Grapes  Cucurbits  Strawberries  Lettuce  Walnuts  Tomatoes  Peppers  Citrus Powdery Mildew, Botrytis, Downy Mildew, Gummy stem blight Bacterial blight, Bacterial canker, Bacterial leaf spot, Target spot, Bacterial speck Tomato late blight & early blight, Diseases:

Regalia ™ SC on Ornamentals Powdery Mildew (Oidium spp) Gray Mold (Botrytis cinerea) Rust (Puccinia antirrhini)  Begonias  Lisianthus  Salvias  Crape myrtle  Petunias  Snapdragons  Freesias  Poinsettias  Zinnias  Gerbera  Roses Diseases

Field Data  Treatments were applied with a tractor-mounted boom sprayer that delivered 50 gal/acre at 100 psi.  Treatment dates: 1=Jan 11; 2=Feb 1; 3= Feb 13; 4=Feb 27 Regalia

Field Data Volume=66 gal/A Applications were made weekly for 14 weeks

Coming soon:  Organic, Concentrated (5%) formulation of Regalia  NEW: MOI Hinokitiol-based broad-spectrum fungicide for Botrytus control…

Potential IR-4 Projects  Test Regalia SC as part of IPM programs in ornamentals, vegetables, fruit, vines (Botrytis, mildews, bacterial diseases. Other diseases ?  Test Regalia SC on turf diseases  Test efficacy against other pathogens, such as oomycetes (Phytophthora spp.)  Bridging studies to organic formulation

MOI-106 Regalia ™ SC (formerly Milsana ® ) Julie Versman, VP Marketing