WORK UP & MANAGEMENT OF SOLITARY PULMONARY NODULE Seifu B Oct-04, 2007
Introduction SPN or ‘Coin’ lesion- common Detected incidentally-0.09 to 0.2% CXR Major ? To R/O Malignancy Defn ; an approximately round lesion, <3cm in diameter, surrounded by normal aerated lung without other abnormality
Etiologies of SPN Numerous causes Malignant Vs Benign Variable frequency
Carcinoid tumors
Malignant Etiologies Incidence of Ca –range from 10-70% Primary Lung Ca All types Most common as SPN= Adenocarcinoma → Squamous cell ca → Large cell Ca Carcinoid tomors Central, endobronchial 20% arise peripherally, as SPN
Metastatic Ca Commonly as multiple As SPN; Melanoma, Sarcoma, Colon Ca, Breast, Kidney, Testes Extra thoracic malignancy + SPN- 25% probability
Benign Etiologies Infectious Granulomas Cause of 80% of benign lesions Most frequent Endemic fungi Mycobacterial Hamartomas 10% benign nodules Xic CXR & CT findings
General Approach to SPN Ideal Resection of all malignant nodules Avoiding resection of all benign ones Implementation = difficult Different approaches exist
Initial diagnostic evaluation Determination of probability of malignancy → Selection of management Based on: Clinical features Radiologic features Quantitative models
Clinical features Probability of malignancy increased with 1.Advanced age One study: 3% in patients b/n 35 & 39, 50% in those > 50 yrs of age 2.Presence of risk factors Smoking!!! Asbestos exposure Family history Diagnosed malignancy
Radiologic features CXR- being replaced with CT Features used: Size Border Calcification Density Growth rate Metabolic activity
Radiologic features… Size Any size –considered malignant until proven otherwise >3cm- more likely to be malignant- 80 t0 90 % Calcification Suggestive of benign Does not rule out malignancy Pattern more important
Patterns of calcification Suggestive of benign Diffuse homogenous Central Concentric Popcorn Of malignancy Reticular Punctate Amorphous Eccentric
Radiologic features… Attenuation Measure of electron density- Hounsfield units Increased density- Benign Not used routinely
Radiologic features… Border Likelihood of malignancy Smooth- 20% Scalloped- 60% Spiculated- 90% Corona radiata- 95%
Bron ca,Hamar, Carci, Pul inf
Radiologic features… Growth rate Review of old X-rays! Malignancy doubling time-20 to 400days Very rapid, or slow- less likely to be malignant Stability on CXR for 2 yrs- benign ? Several pitfalls CT- preferred
Radiologic features… Other helpful signs : Morphology Wall thickness of cavitating nodules Nodules with tails towards the hilum
Radiologic features… Metabolic imaging FDG-PET More accurate than CT Ix- SPN> 1cm & intermediate probability of malignancy Sensitivity & Specificity- 96 & 78% Detection of metastasis- staging False positive & negative results
Quantitative Models Use likelihood ratios to estimate the probability that a SPN is malignant Based on clinical & radiologic characteristics
Nodule Sampling If no sufficient evidence Different options- based on size, location & availability Bronchoscopy Needle aspiration Needle biopsy Surgical resection
Initial Management Decision made after initial assessment Various approaches Individualized based on: Pretest probability of cancer Cost effectiveness Patient preference
Initial Management… One approach When probability of cancer is Low (< 12%)- Radiologic follow up Intermediate(12-69%)- CT & PET High (69-90%)- CT followed by biopsy or surgery Very High (>90%)-Surgery
References Harrison's Prin. Of Int. Med 16 th Edition Up To Date 15.2 NEJM-2003: 348 Granger's Diagnostic Radiology