Therapeutic Intervention of Ebola Virus Infection in Rhesus Macaques with the MB-003 Monoclonal Antibody Cocktail by James Pettitt, Larry Zeitlin, Do H.

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Presentation transcript:

Therapeutic Intervention of Ebola Virus Infection in Rhesus Macaques with the MB-003 Monoclonal Antibody Cocktail by James Pettitt, Larry Zeitlin, Do H. Kim, Cara Working, Joshua C. Johnson, Ognian Bohorov, Barry Bratcher, Ernie Hiatt, Steven D. Hume, Ashley K. Johnson, Josh Morton, Michael H. Pauly, Kevin J. Whaley, Michael F. Ingram, Ashley Zovanyi, Megan Heinrich, Ashley Piper, Justine Zelko, and Gene G. Olinger Sci Transl Med Volume 5(199):199ra ra113 August 21, 2013 Published by AAAS

Fig. 1 Truncated telemetry analysis of NHPs.Baseline temperatures for each NHP were determined before challenge. James Pettitt et al., Sci Transl Med 2013;5:199ra113 Published by AAAS

Fig. 2 Survival, mAb titers, and viral levels during the therapeutic protocol. James Pettitt et al., Sci Transl Med 2013;5:199ra113 Published by AAAS

Fig. 3 Clinical analysis and observations for NHPs.Complete blood counts (CBCs) and chemical analyses were performed on samples collected over the course of the study (days 0, 3, 5, 7, 10, 14, 21, and 28). James Pettitt et al., Sci Transl Med 2013;5:199ra113 Published by AAAS