PET in Colorectal Cancer. Indications for FDG PET Rising marker, (-) CT/MRI Nonspecific findings on CT/MRI, recurrence or post treatment changes? Known.

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Change in longest diameter = -19%. Change in sum of perpendicular diameters = -21%
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Presentation transcript:

PET in Colorectal Cancer

Indications for FDG PET Rising marker, (-) CT/MRI Nonspecific findings on CT/MRI, recurrence or post treatment changes? Known metastases; evaluate extent or disease or identify other sites of recurrence Evaluate response to chemotherapy

LV 12/09/93 04/23/9608/22/96 PET-FDG SCAN IN RECTAL CA

Coronal MSKCCAL361200

Case 1

Comparison of PET and CT N=40 pts. (93 biopsies) W CT =0.73+/-.06* W PET =0.97/-.02* *P<.001

Biopsy Correlated Finding

Diagnostic Imaging in Oncology Detection Differential Diagnosis Tumor biology relevant to therapy Staging Recurrence Response

PET in Colorectal Cancer PET accuracy between % > CT (75%) Among pt.s with suspected recurrence, SUV > 3.5 has a 90% probability of tumor, and a 10% prob of being a benign lesion Most common reasons for missing lesions is size (< 1 cm in diameter), location (peritoneum), and artifact (lesion near high count area) PET >> CT for Rx response in rectal Ca

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