Atypical Organisms
Mycoplasmas Characteristics –Lack cell walls –Pleomorphic (fried egg) –NM –FA-Obligate anaerobes Examples –M. genitalium –M. pneumoniae –M. hominis Diseases –Pneumonia –Urogenital infections
Rickettsias GN (very little PG) Intracellular parasites Aerobic Slow reproduction Cell lysis for release Arthropod vectors Species –R. rickettsii –R. typhi –R. prowazekii
RMSF R. rickettsii Dermacentor tick –STD for ticks –Salivary gland host blood Humans, rodents Damage endothelium CS –F/N/V/myalgia –Spotted rash, pettechiae –Gangrene, paralysis –Encephalitis, death Dx : IFA, agglutination Tx: AB, remove tick
Epidemic Typhus R. prowazekii Pediculis louse Human host CC/CS –Fever, depression –Rash Dx: IFA Tx: AB Pv: hygeine, sanitation
Murine (Endemic) Typhus R. typhi Flea (rat, cat) Rodent (murine) reservoir Human exposure to fleas CC/CS –Fever, headache, myalgia –Rash on trunk and chest Dx: IFA Tx: AB Pv: Flea control
Scrub Typhus Orientia tsutsugamushi Red Mites (chiggers) Rodents and Humans Pacific –Asia, Japan –Australia CS –Fever, headache –Myalgia, lymphadenopathy –Rash on trunk Tx: Ab Pv: mite control, repellent
Ehrlichia and Anaplasma Emerging disease (1987) Intracellular parasite in WBC Hard Ticks –Lone Star (Ambylomma) –Deer (Ixodes) –Dog (Dermacentor) Species –E. chaffeensis –E. equi (Anaplasma) CC/CS: –Fever, rash, leukopenia Dx: IFA Tx: AB Pv: Tick control
Chlaymdia Intracellular parasite No cell wall 2 forms during development –Elementary bodies (EB) Dormant, infective –Reticulate bodies Intracellular inclusions Species –C. trachomatis –C. pneumoniae –C. psittaci
Chlamydia trachomatis Reportable STI Human cells with EB receptors –Respiratory –Female repro –Lower GI (rectum) CS –Ocular lesions (trachoma) scar cornea blindness or –Lymphogranuloma –Buboes –Genital sores –Urethritis, vagninitis, proctitis Dx: Giemsa stain, culture Tx: AB PV: safe sex
Chlamydia pneumoniae Community acquired Droplet transmission CS –Sinusitis –Bronchitis –Chronic cough –Pneumonia –+/- atherosclerosis Dx: FA Tx: AB
Chlamydia psittaci Zoonotic Parrot fever Aerosolized EB in feces CS –Flu like symptoms –Pneumonia Dx: serology Tx: AB Pv: husbandry Quarantine
Spirochetes GN, helical/coiled Endoflagella Corkscrew shape Genera –Treponema –Borrelia –Leptospira
Treponema Human pathogen Obligate intracellular parasite T. pallidum pallidum Fastidious – CH2O use –Host: FA, Protein, enzymes Double membrane –2 flagella –Lack of surface proteins STI (STD) Tx : AB [penicillins] Syphilis
CS/Stages –1 : Primary Active Blister –2 : Disseminated Latent Rash –3 : Tertiary CV (aneurysms) NS (meninges) Skin/Bone (Gummas) –4: Congenital Fetus (stillborn) 3 12
Treponema pallidum … T. p endemicum –“Bejel” –MM –gummas T. p pertenue –“Yaws” –Skin: granular, draining tracts T. carateum –“Pinta” –Skin papules flat Hyper & depigmentation
Borrelia Spirochete –Endoflagella –Extracellular parasite Species and Strains –B. burgdorferi B. andersoniii B. japonica B. valaisiana –B. lonestari –B. turcica –B. recurrentis Genetics –Linear chromosome –Plasmids Zoonotic Arthropods –Ticks –Fleas –Lice Dx: IF, serology, organism in blood
B. burgdorferi GN spirochete Deer mice host, deer Hard tick (Ixodes) spread (3x) Lyme’s disease CS –Bull’s eye rash –Myalgia –Neuropathy –Arthralgia Chronic Arthritis »MO IL-1, IL-6 TH 17 cells Dx: serology Tx: AB Pv: tick control, repellent
Relapsing Fever Borrelia recurrentis Arthropod vector –Lice (human) –Soft Tick Rodent reservoir Humans CS: fever, malaise Dx: Blood smear Tx: AB Pv: vector control
Leptospira Spirochete Zoonotic Species –L. interrogans (humans) –L. …….. Transmission –Contam Urine water –Primary Hosts Rats Mice Moles –Secondary Hosts Dogs Deer Rabbits Raccoons Skunks Opossums
Leptospirosis CS –N/V/F/headache –Pneumonia –Migrates through tissues Renal Meningitis Liver failure (Weil’s Ds) Respiratory distress Dx: –Giemsa stain –titers Tx: –AB – fluids Pv: vaccinate animals NA Epidemic ~1620 (Pilgrims) Out breaks: Civil War, WWI, WWII
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