Polymerisation Chemistry

P4 – Case Studies Hyperbranched PMMA (HB-PMMA)Hyperbranched PMMA (HB-PMMA) Hyperbranched aliphatic polyurethanes (HB-PU)Hyperbranched aliphatic polyurethanes (HB-PU) Highly syndiotactic PMMA and block copolymers at r.t. (S-PMMA)Highly syndiotactic PMMA and block copolymers at r.t. (S-PMMA) Novel polymer beads for solid-phase organic synthesisNovel polymer beads for solid-phase organic synthesis

HB-Polymers Tunable viscosityTunable viscosity Modifiable solubility characteristicsModifiable solubility characteristics End-group dominated propertiesEnd-group dominated properties One-pot synthesisOne-pot synthesis Reduced crystallinityReduced crystallinity Increased blend compatibilityIncreased blend compatibility

HB-PMMA Solution polymerisation of MMA as batch model reactionSolution polymerisation of MMA as batch model reaction  AIBN/xylenes; 20% MMA; time vs conversion; validation data Solution polymerisation of HB-PMMA as batch model reactionSolution polymerisation of HB-PMMA as batch model reaction  Independently reproduced Scale-up of branching agentScale-up of branching agent

HB-PU Small scale synthesis of HB-PUSmall scale synthesis of HB-PU Effect of reaction parameters investigatedEffect of reaction parameters investigated  Time, temperature, addition sequence, catalyst, solvent Small scale synthesis of linear PU model polymerSmall scale synthesis of linear PU model polymer

S-PMMA Improved catalyst availableImproved catalyst available  Better reaction control, higher syndiotacticity

Polymer Beads Successful catalyst optimisation (small scale)Successful catalyst optimisation (small scale)  Homogeneous crosslinking possible

Immediate Targets I PMMA scale-up reactor runsPMMA scale-up reactor runs Model validationModel validation Feedback loop established Small scale HB-PMMA model reactionSmall scale HB-PMMA model reaction HB-PMMA scale-up reactor runsHB-PMMA scale-up reactor runs Implementation of new modelImplementation of new model

Immediate Targets II Complete kinetic data set for HB-PUComplete kinetic data set for HB-PU Small scale solution polymerisationSmall scale solution polymerisation  Conv., DoB, MW, MWD Identify suitable matrix for MALDI-tofIdentify suitable matrix for MALDI-tof Model implementation/validationModel implementation/validation

Funding Opportunities EPSRCEPSRC  High-added value polymers (electronics, biomedical, pharmaceutical (enabling)) MMIMMI  LINK programme suggested HuntsmanHuntsman  HB-PU – Synthesis and scale-up technology  Sign of interest

Funding Opportunities AveciaAvecia  CombiChem Supports – Synthesis and scale-up technology – immediate market potential  Initial discussion meeting BP/DTIBP/DTI  Photovoltaics/Molecular electronics contribution – IC Chem/ IC Physics initiative  Discussions needed Basic Technology Initiative 2 nd callBasic Technology Initiative 2 nd call  Do programme objectives match P4 philosophy?

Department of Trade & Industry EPSRC “The overall objective is to help the UK to become the world’s leading manufacturing base of the next generation of complex, high value chemicals”

4 key aims 1.Reducing time taken to develop and make complex molecules (using both chemical & biological processes) 2.Improving competitiveness by using innovative processes & technologies 3.Raising skills, particularly in SMEs, to rapidly adopt new processes & technologies 4.Increasing awareness of new technologies and emerging best practice through networking 1.Reducing time taken to develop and make complex molecules (using both chemical & biological processes) 2.Improving competitiveness by using innovative processes & technologies 3.Raising skills, particularly in SMEs, to rapidly adopt new processes & technologies 4.Increasing awareness of new technologies and emerging best practice through networking

Target Molecules Pharmaceuticals including DNA active ingredients and those derived from human genome work Intermediates for pharmaceuticals Additives and dyestuffs Chemicals for electronics, battery systems, memory, display and optical technologies Agrochemicals High performance materials for healthcare, packaging, housing, clothing, transport, etc. Pharmaceuticals including DNA active ingredients and those derived from human genome work Intermediates for pharmaceuticals Additives and dyestuffs Chemicals for electronics, battery systems, memory, display and optical technologies Agrochemicals High performance materials for healthcare, packaging, housing, clothing, transport, etc.

Technical Priorities New chiral formation or separation technologies New catalysis technologies Novel chemical synthesis Innovative separation & reactor technologies New media, such as supercritical and ionic fluids New chiral formation or separation technologies New catalysis technologies Novel chemical synthesis Innovative separation & reactor technologies New media, such as supercritical and ionic fluids

Technical Priorities Enhanced fields such as photo, sonic, & microwave Biological processing Innovative process design Characterisation of reactions Novel pilot plant On-line analysis & control Enhanced fields such as photo, sonic, & microwave Biological processing Innovative process design Characterisation of reactions Novel pilot plant On-line analysis & control

What can we support? Scoping desk based research / survey /study < 4 months < £50k Pilotlab based research < 6 months < £100k Demoplant based proof of performance < 12 months < £100k Collaborative, pre-competitive research

Criteria for support of : Min. One industrial and One research base partner Pre-competitive research (not near to market) Additionality (would not otherwise take place) Exploitation (clearly identified route) Overall limit 50% public funding (SMEs up to 60%)

Min. One industrial and One research base partner GSK, Pfizer, AstraZeneca Pre-competitive research Support performance and versatility, SPR tuned via synthesis Additionality Convincing Exploitation Clear Overall limit 50% Should be possible : CombiChem Supports

: Conducting Polymers Min. One industrial and One research base partner Merck, Avecia, SME?, IC Physics Pre-competitive research Scale-up, SPRs, composition Additionality Convincing Exploitation Needs to be worked out Overall limit 50% Needs to be negotiated

Assessment Criteria : Fit to aims and technical priorities (impact) Quality of Science, Engineering & Technology (excellence) Collaboration (mix of partners & disciplines) Management (project plan & milestones) Exploitation (route to market & plan)

Approved projects BRITEST Technology Transfer project Chemicals Behaving Badly project Chiral Separations Pilot study Hyperbranched Polymers Pilot study

Contact Point Richard Bahu MMI Programme Coordinator The Oxis Partnership April Croft Faringdon Road Shippon, Abingdon Oxfordshire OX13 6LN Tel/Fax: Richard Bahu MMI Programme Coordinator The Oxis Partnership April Croft Faringdon Road Shippon, Abingdon Oxfordshire OX13 6LN Tel/Fax: