Simonetta Scalvini Fondazione Salvatore Maugeri, Telemedicine Service, Lumezzane (BS), Italy Clinical Results Bruxelles, 16tn June 2011

16th June Baseline characteristics of patients TELEMACO ( ) NRS (2006 – 2009) No of patients Age, years (mean ± SD) ± ± 11 Female (%)33 (25%)226 (28%) Onset of symptoms < 6 months (% patients) Onset of symptoms > 6 months (% patients) 81 (62%) 48 (37%) 292 (36%) 507 (63%) NYHA Class II NYHA Class III-IV 17 (13%) 113 (82%) 0 (0%) 802 (100%) Patients with 0 – 1 co-morbidity (% patients) Patients with 2 co-morbidities 104 (80%) 26 (20%) 408 (63%) 294 (37%) Patients with 2 admissions in 6 months before (% patients) 40 (31%) 208 (26%) Home Base Telemanagment in Chronic Heart failure (CHF)

Home Base Telemanagment in CHF: clinical results 3 Telephone calls and actions taken TELEMACO ( ) NRS (2006 – 2009) for weekfor HBT periodfor weekfor HBTperiod No of scheduled calls/patient No of unscheduled calls/patient No of ECG transmissions/patient No of changes in therapy/patient No of ED suggested Clinical events TELEMACO ( ) NRS (2006 – 2009) Cardiovascular (including HF) readmission0.27 ± ±0.63 Non Cardiovascular readmission0.15 ± ± th June 2011Outcome T0T1p Ejection Fraction (%)31.8 ± ± Walking Test351 ± ± Minnesota QoL42.5 ± ±

16th June Baseline characteristics of patients TELEMACO ( ) No of patients Age, years (mean ± SD) ± 8 Female (%)84 (21%) Diagnosis58 % in clinical stable conditions Therapy 46 % in oxygen-therapy for 24H 27 % in oxygen-therapy only over night or under-stress Functional exams55 % with FEV 1 < 50% Smoke history - Smokers - No smokers - - Ex smokers 62 (37%) 39 (16%) 282 (10%) BMI: - Under weight - Normal weight - Over weight - Obese 15 (4%) 121 (31%) 142 (36%) 104 (26%) Home Base Telemanagment in Chronic Obstructive Pulmonary Disease (COPD) severe or very severe COPD (III - IV GOLD class )

5 16th June 2011 Home Base Telemanagment in COPD: results Telephone calls and actions taken TELEMACO ( ) for weekfor HBT period No of scheduled calls/patient1.07 ± ± 7.6 No of unscheduled calls/patient0.05 ± ±1.2 No of SpO2 transmissions/patient1.0 ± ± 8.2 No of changes in therapy/patient No of ED suggested Clinical events TELEMACO ( ) Pulmonary readmission (per patient for HBT period)70 (0.18) Non Pulmonary readmission (per patient for HBT period)47 (0.12) Outcome Coupled value T1-T0p San George Questionnaire: - Symptoms - Activity - Impact

Second opinion for GPs: Results Total No of teleconsultation TELEMACO ( ) At patients home489 (10%) Patients follow up2828 (58%) Patients new symptoms1890 (39%) Patients age (y) Sex (male) 62 ± (45%)

7 Second opinion for GPs: results After the second opinion, GPs change their decisions in the 87% of the patients

Second opinion on cranium TC scan: results Total No of teleconsultation TELEMACO ( ) Stroke Cranial Trauma Patients mean age (y) Male 67 ±17 75 (51%) To send in other hospital (before teleconsultation) After teleconsultation 78 (53%) 19 (18%)