Recurrence of Malignancy after Transplantation ANZDATA - Australian and New Zealand Dialysis and Transplant Registry NSW Cancer Council

Recurrence of Malignancy ISSUES Donor Recipient

Timing of Cancer Diagnosis Tx DEATH CANCER DIALYSIS PRE Dx POST Dx

Number of Patients with Cancer ANZDATA Database 1999 CancerPre DxPost Dx Skin Kidney Myeloma Bladder Breast Colon Prostate Melanoma Rectal Cervix ALL Non skin Cancer

Recurrence of cancer after RENAL TRANSPLANTATION ANZDATA pre transplant Cancers # Tx Recurrence –Colon230 –Breast200 –Female genital202 –Prostate 51 –Bladder241 –Kidney372 –Ureter 10 –Melanoma192 –Lymphoma100 –Myeloma 40 –Other non-skin473 –TOTAL21011 –No prior Cancer11684

Recurrence of cancer after RENAL TRANSPLANTATION Dead Tx ANZDATA Months Follow Up

ANZDATA Patient survival after Renal Transplantation CD

Diagnosis of Cancer pre-Transplant Patients at risk = 27,495 Pt Years at risk = 1,361,200

Survival after Diagnosis Cancer diagnosed pre-dialysis Median Survival in Years ANZDATA

Survival after Diagnosis Cancer diagnosed post-dialysis Median Survival in Years ANZDATA

Comparison of 5 year survival of general and dialysis populations

Breast Cancer ANZDATA 1999 vs NSW Cancer Databases POPULATIONS 43% 33%

Myeloma ANZDATA 1999 vs NSW Cancer Databases POPULATIONS

Colon Cancer ANZDATA 1999 vs NSW Cancer Databases POPULATIONS

Bladder Cancer ANZDATA 1999 vs NSW Cancer Databases POPULATIONS

Kidney Cancer ANZDATA 1999 vs NSW Cancer Databases POPULATIONS

Melanoma ANZDATA 1999 vs NSW Cancer Databases POPULATIONS

Lymphoma ANZDATA 1999 vs NSW Cancer Databases POPULATIONS

Lymphoma Melanoma Kidney Bladder Colon Breast

Cancer in Uraemic populations ANZDATA - are the data real? review of all cases review causes of death review metastasis diagnoses review therapy Acknowledgements: Brian Livingston, Ross Sheil