1. ANZDATA Registry Annual Report 2013
TRANSPLANTATION
CHAPTER 8
ANZDATA Registry Annual Report 2013

2. ANZDATA Registry Annual Report 2013
Figure 8.1
Number of Kidney Transplant Operations
Total (Living Donors)
Year
Australia
New Zealand
1st
2nd
3rd
4th
5th
Total
1963 5 1
6 (0)
1964 2
2 (0)
1965 12
14 (3)
1 (1)
1966 18
20 (5) 10 3
13 (0)
1967 69
71 (2) 4
23 (1)
1968 97
107 (0) 17
21 (2)
1969
149
161 (0) 39
44 (0)
1970
168
182 (1) 21
25 (0)
1971
207 22
230 (1) 26 6
32 (1)
1972
183 16
199 (2) 43 8
51 (1)
1973
213 30
244 (7) 50
62 (0)
1974
224 35
263 (6)
41 (3)
1975
271 29
304 (7) 61 13
74 (2)
1976
223 41
268 (10) 38
52 (1)
1977
265 57
326 (16) 46
58 (4)
1978
269
314 (17) 11
57 (11)
1979
293
333 (34)
79 (16)
1980
287 63 9
359 (36)
74 (18)
1981
306 58
374 (35) 51
60 (10)
1982
321 72
399 (53) 48
65 (8)
1983
272
347 (48) 25
98 (11)
1984
362
445 (48)
74 (16)
1985
318 79
415 (36) 60
88 (6)
1986
366 7
438 (32) 19
105 (13)
1987
310
392 (40)
79 (20)
1988
391 62
466 (46)
78 (8)
1989
433
491 (48) 71
83 (12)
1990
387 45
443 (59) 86 14
102 (23)
1991
386 70
470 (78)
77 (13)
1992
404
477 (70)
105
115 (17)
1993
385
459 (66) 68
83 (20)
1994
384
440 (103)
1995
371
442 (94) 84
94 (24)
1996
416
475 (115) 88
96 (26)
1997
447
505 (147)
101
112 (31)
1998
443
518 (161) 95
106 (31)
1999
403
455 (169)
112 (42)
2000
476 47
531 (181) 91
2001
488
541 (213)
110 (43)
2002
537
604 (230)
103
117 (48)
2003
472
543 (218) 94
111 (44)
2004
583 53
650 (244) 98
105 (48)
2005
539 67 15
623 (246) 87
93 (46)
2006
549
641 (273) 80
90 (49)
2007
527 75
615 (271)
112
123 (58)
2008
708
813 (354)
111
122 (69)
2009
674
773 (327)
109
121 (67)
2010
744 83
846 (296)
104
110 (60)
2011
825 (255)
110
118 (57)
2012
747
845 (238) 99
108 (54)
ANZDATA Registry Annual Report 2013

3. ANZDATA Registry Annual Report 2013
Figure 8.2
ANZDATA Registry Annual Report 2013

4. ANZDATA Registry Annual Report 2013
Figure 8.3
ANZDATA Registry Annual Report 2013

5. ANZDATA Registry Annual Report 2013
Figure 8.4a
ANZDATA Registry Annual Report 2013

6. ANZDATA Registry Annual Report 2013
Figure 8.4b
ANZDATA Registry Annual Report 2013

7. ANZDATA Registry Annual Report 2013
Figure 8.5
ANZDATA Registry Annual Report 2013

8. ANZDATA Registry Annual Report 2013
Figure 8.6
ANZDATA Registry Annual Report 2013

9. ANZDATA Registry Annual Report 2013
Figure 8.7
* Pre-emptive transplant patients included
ANZDATA Registry Annual Report 2013

10. ANZDATA Registry Annual Report 2013
Figure 8.8
* Pre-emptive transplant patients included
ANZDATA Registry Annual Report 2013

11. Graft Number and Age of Patients Transplanted 2012
Figure 8.9
Graft Number and Age of Patients Transplanted
2012
Donor
Source
Graft No.
Age Groups
Total
00-04
05-14
15-24
25-34
35-44
45-54
55-64
65-74
75-84
Australia
Deceased 1 2 6 16 66 85
143
155 58
533 4 12 25 14 61 3 5 11
Living Donor 13 29 23 41 40 43 18
214 19 7 53 99
149
218 80
843
New Zealand 10 9 50 8 17 49 22 34
108
ANZDATA Registry Annual Report 2013

12. ANZDATA Registry Annual Report 2013
Figure 8.10
ANZDATA Registry Annual Report 2013

13. ANZDATA Registry Annual Report 2013
Figure 8.11
ANZDATA Registry Annual Report 2013

14. Transplantation Rate - Age Group 15-64 years 2003 - 2012
Figure 8.12
Australia
Transplantation Rate - Age Group years
Year
Caucasian
Aboriginal and
Torres St. Islanders
All Patients Tx
Dialysed
Rate
2003
414
3790
10.9% 12
783
1.5%
478
5251
9.1%
2004
491
3875
12.7% 25
856
2.9%
581
5438
10.7%
2005
460
4040
11.4% 20
930
2.2%
548
5716
9.6%
2006
481
4241
11.3% 27
989
2.7%
579
6039
2007
471
4380
10.8% 17
1065
1.6%
557
6331
8.8%
2008
602
4488
13.4% 29
1176
2.5%
724
6632
2009
574
4497
12.8% 23
1199
1.9%
687
6719
10.2%
2010
607
4438
13.7%
1215
734
6727
2011
550
4474
12.3%
1274
2.0%
695
6879
10.1%
2012
585
4512
13.0% 19
1337
1.4%
7082
10.4%
ANZDATA Registry Annual Report 2013

15. Transplantation Rate - Age Group 15-64 years 2003 - 2012
Figure 8.13
New Zealand
Transplantation Rate - Age Group years
Year
Caucasian
Maori
Pacific People
All Patients Tx
Dialysed
Rate
2003 64
545
11.7% 16
531
3.0% 13
271
4.8%
101
1442
7.0%
2004 65
542
12.0% 10
558
1.8% 12
285
4.2% 96
1483
6.5%
2005 73
568
12.9% 3
563
0.5%
303
1.0% 82
1523
5.4%
2006 59
567
10.4% 9
606
1.5% 5
322
1.6% 80
1599
5.0%
2007
576
14.2% 15
616
2.4% 6
344
1.7%
111
1648
6.7%
2008 84
586
14.3%
620
1.9%
376
112
1699
6.6%
2009 77
599
637
2.0%
405
1783
5.7%
2010 62
593
10.5% 17
662
2.6% 8
445 95
1860
5.1%
2011 67
11.1% 18
652
2.8% 7
467
104
1887
5.5%
2012 60
601
10.0%
672
488
1.4% 88
1942
4.5%
ANZDATA Registry Annual Report 2013

16. New Transplanted Patients 2008 - 2012 Related to Ethnicity
Figure 8.14
New Transplanted Patients
Related to Ethnicity
Race
2008
2009
2010
2011
2012
Australia
813 (100.0%)
773 (100.0%)
846 (100.0%)
825 (100.0%)
845 (100.0%)
Caucasian
675 (83.0%)
651 (84.2%)
706 (83.5%)
657 (79.6%)
669 (79.2%)
Aboriginal/Torres St. Islanders
31 (3.8%)
24 (3.1%)
28 (3.3%)
28 (3.4%)
20 (2.4%)
Asian
83 (10.2%)
75 (9.7%)
83 (9.8%)
97 (11.8%)
88 (10.4%)
Other
24 (3.0%)
23 (3.0%)
29 (3.4%)
43 (5.2%)
68 (8.0%)
New Zealand
122 (100.0%)
121 (100.0%)
110 (100.0%)
118 (100.0%)
108 (100.0%)
93 (76.2%)
91 (75.2%)
71 (64.5%)
77 (65.3%)
74 (68.5%)
7 (5.7%)
5 (4.1%)
8 (7.3%)
11 (9.3%)
11 (10.2%)
Maori
12 (9.8%)
19 (15.7%)
20 (18.2%)
20 (16.9%)
15 (13.9%)
Pacific
10 (8.2%)
6 (5.0%)
9 (8.2%)
9 (7.6%)
7 (6.5%) -
2 (1.8%)
1 (0.8%)
1 (0.9%)
ANZDATA Registry Annual Report 2013

17. Transplants in each Region 2008 - 2012 Number of Operations
Figure 8.15
Transplants in each Region
Number of Operations
(per Million Population per year)
State
2007
2008
2009
2010
2011
Queensland
136 (32)
140 (32)
137 (31)
155 (35)
159 (35)
New South Wales / ACT *
243 (33)
238 (32)
265 (35)
232 (31)
247 (32)
Victoria / Tasmania *
246 (42)
233 (39)
285 (48)
278 (46)
268 (44)
South Australia / NT *
110 (60)
83 (45)
82 (44)
74 (40)
88 (47)
Western Australia
78 (36)
79 (35)
77 (34)
86 (37)
83 (34)
Australia
813 (38)
773 (35)
846 (38)
825 (37)
845 (37)
* For calculation of population related totals,
the populations of these States were summed
ANZDATA Registry Annual Report 2013

18. ANZDATA Registry Annual Report 2013
Figure 8.16
ANZDATA Registry Annual Report 2013

19. ANZDATA Registry Annual Report 2013
Figure 8.17
NSW population excludes residents of the Southern Area Health Service
ACT population includes residents of the Southern Area Health Service
Medical services in the ACT service the Southern Area Region
ANZDATA Registry Annual Report 2013

20. Summary of Kidney Transplantation Australia 1963 - 2012 Performed
Figure 8.18
Summary of Kidney
Transplantation
Australia
Performed
Functioning*
Deceased
Donor
First
13386
5073
Second
1997
610
Third
326
105
Fourth 48 14
Fifth 6 2
Total
15763
5804
Living
4462
3023
409
251 59 44 10 7 1
4941
3325
20704
9129
* Lost to follow up not included
ANZDATA Registry Annual Report 2013

21. Summary of Kidney Transplantation Australia 1963 - 2012 Graft No.
Figure 8.18
Summary of Kidney
Transplantation
Australia
Graft No.
Performed
Functioning*
Deceased
Donor
First
13386
5132
Second
1997
615
Third
326
105
Fourth 48 14
Fifth 6 2
Total
15763
5868
Living
4462
3121
409
262 59 44 10 8 1
4941
3435
Unknown 15
20704
9320
* Lost to follow up not included
ANZDATA Registry Annual Report 2013

22. Summary of Kidney Transplantation New Zealand 1965 - 2012 Performed
Figure 8.19
Summary of Kidney
Transplantation
New Zealand
Performed
Functioning*
Deceased
Donor
First
2282
748
Second
400 78
Third 76 18
Fourth 7
Total
2765
844
Living
998
626 82 48 6 4
1086
678
Unknown 2
3851
1524
* Lost to follow up not included
ANZDATA Registry Annual Report 2013

23. Functioning Transplants 2003 - 2012
Figure 8.20
Functioning Transplants
Transplanting Region, Australia and New Zealand
(Number Per Million Population)
Year
QLD
NSW/ACT *
VIC/Tas *
SA/NT * WA
Australia NZ
2003
1243 (326)
1976 (282)
1593 (295)
726 (419)
551 (282)
6089 (306)
1164 (289)
2004
1289 (330)
2077 (295)
1671 (306)
773 (444)
585 (295)
6395 (318)
1218 (298)
2005
1329 (333)
2148 (303)
1756 (317)
783 (445)
640 (317)
6656 (326)
1243 (301)
2006
1376 (336)
2232 (312)
1870 (333)
825 (464)
684 (332)
6987 (338)
1256 (300)
2007
1425 (341)
2286 (316)
1961 (344)
870 (484)
709 (335)
7251 (345)
1300 (307)
2008
1505 (352)
2394 (327)
2095 (362)
912 (502)
748 (343)
7654 (358)
1350 (316)
2009
1576 (361)
2497 (336)
2252 (382)
935 (508)
787 (350)
8047 (370)
1404 (325)
2010
1649 (373)
2648 (353)
2416 (404)
975 (524)
818 (356)
8506 (386)
1440 (330)
2011
1717 (384)
2740 (362)
2573 (426)
988 (528)
860 (366)
8878 (398)
1483 (337)
2012
1810 (400)
2866 (374)
2718 (444)
1029 (547)
897 (372)
9320 (413)
1524 (344)
* For calculation of population related totals, the population of these States were combined
Patients lost to follow up are not included
ANZDATA Registry Annual Report 2013

24. ANZDATA Registry Annual Report 2013
Figure 8.21
ANZDATA Registry Annual Report 2013

25. ANZDATA Registry Annual Report 2013
Figure 8.22
ANZDATA Registry Annual Report 2013

26. ANZDATA Registry Annual Report 2013
Figure 8.23
ANZDATA Registry Annual Report 2013

27. ANZDATA Registry Annual Report 2013
Figure 8.24
ANZDATA Registry Annual Report 2013

28. Age of All Functioning Transplant Patients
Figure 8.25
Age of All Functioning Transplant Patients
Resident Country at Transplant 31-Dec-2012
Donor
Source
Graft No.
Age Groups
Total
00-04
05-14
15-24
25-34
35-44
45-54
55-64
65-74
75-84
85-94
Australia 12
136
292
708
1559
2258
2508
1527
314 6
9320
Deceased 1 40 89
249
715
1240
1538
1022
228 5
5132 2 - 4 8
103
198
163 82 16
615 3 25 41 18 11
105 14 44 99
297
848
1486
1723
1115
244
5868
Living Donor
180
376
627
687
720
386 65
3136 32 71 64 56 21
264 19 92
193
411
711
772
785
412 70
3452
New Zealand 26 59
120
221
423
236 46
1524 51
178
224
151
748 22 7 78 13 53
102
215
251
160
844 62
104
162 76
628 17 10 48 67
119
171
172
680
ANZDATA Registry Annual Report 2013

29. ANZDATA Registry Annual Report 2013
Figure 8.26a
ANZDATA Registry Annual Report 2013

30. ANZDATA Registry Annual Report 2013
Figure 8.16b
ANZDATA Registry Annual Report 2013

31. ANZDATA Registry Annual Report 2013
Figure 8.27a
ANZDATA Registry Annual Report 2013

32. ANZDATA Registry Annual Report 2013
Figure 8.27b
ANZDATA Registry Annual Report 2013

33. Functioning Transplant Patients - Resident Country at Transplant
Figure 8.28
Functioning Transplant Patients - Resident Country at Transplant
Related to Ethnicity and Age Group 31-Dec-2012
Gender
Racial Origin
Prevalent Age Groups
Total
00-04
05-14
15-24
25-34
35-44
45-54
55-64
65-74
75-84
85-94
Australia 12
136
292
708
1559
2258
2508
1527
314 6
9320
Female
Caucasian 2 34
100
235
492
690
778
524
132
2989
Aboriginal/TSI - 7 21 25 5 83
Asian 1 4 8 30 78
101
133 47
409
Other 23 26 29 9
131 48
118
295
617
845
957
585
141
3612
Male 68
147
355
808
1219
1335
852
158
4952 3 10
110 13 32
126
139 63 11
474 19 39 43 17
172 88
174
413
942
1413
1551
173
5708
New Zealand 59
120
221
386
423
236 46
1524 28 75
115
129 76 20
477 14 52
Maori 58
Pacific 38 33 98 91
625 22 45
102
177
193 16
673 27 74 51 73
123
228
265
145
899
ANZDATA Registry Annual Report 2013

34. ANZDATA Registry Annual Report 2013
Figure 8.29
ANZDATA Registry Annual Report 2013

35. ANZDATA Registry Annual Report 2013
Figure 8.30
ANZDATA Registry Annual Report 2013

36. ANZDATA Registry Annual Report 2013
Figure 8.31
Graft Loss Rate
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
Australia
6401
6739
7018
7297
7602
8064
8427
8893
9331
9723
Death with Function
2.2%
2.1%
2.3%
2.0%
1.7%
1.6%
Loss of Graft Function
2.6%
3.1%
2.7%
2.4%
2.5%
2.9%
All Losses
4.9%
5.2%
5.0%
4.4%
4.6%
4.3%
4.7%
4.1%
New Zealand
1224
1269
1311
1333
1379
1422
1471
1514
1558
1591
3.2%
1.8%
3.4%
3.5%
4.0%
5.6%
6.0%
6.1%
3.9%
ANZDATA Registry Annual Report 2013

37. Year of Graft Loss Due to Death or Failure 2003 - 2012
Figure 8.32
Year of Graft Loss Due to Death or Failure
Loss
Cause of Failure
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
Total
Australia
Failed
Death with Function
146
165
175
148
177
221
164
1653
Rejection - Acute 3 5 7 11 10 17 8 84
Chronic Allograft (CAN)
112
145
136
108
133
174
153
149
151
178
1439
Rejection - Hyperacute - 1 2 4
Vascular 15 18 13 14 6
126
Technical Problems 33
Glomerulonephritis 12 16 23
150
Non Compliance 9 75
Other 20 19 26 25
184
314
358
326
359
411
380
387
440
415
3748
New Zealand 27 31 34 44 41
324 28
212 38 21 39 60 48 74 81 85 55 68 64 72 65
672
ANZDATA Registry Annual Report 2013

38. ANZDATA Registry Annual Report 2013
Figure 8.33
Graft Losses
Cause of Loss
Australia
New Zealand
Graft Function
<1 year
>= 1 year
Any Time
Death with functioning Graft
Cardiac
19 (27%)
178 (22%)
197 (22%)
5 (50%)
44 (29%)
49 (30%)
Vascular
7 (10%)
69 (8%)
76 (9%)
1 (10%)
8 (5%)
9 (6%)
Infection
29 (41%)
133 (16%)
162 (18%) -
23 (15%)
23 (14%)
Social
2 (3%)
66 (8%)
68 (8%)
Malignancy
5 (7%)
276 (34%)
281 (32%)
2 (20%)
53 (35%)
55 (34%)
Miscellaneous
8 (11%)
93 (11%)
101 (11%)
15 (10%)
16 (10%)
Total
70 (100%)
815 (100%)
885 (100%)
10 (100%)
151 (100%)
161 (100%)
Graft Failure
Rejection - Acute
30 (21%)
25 (2%)
55 (5%)
6 (4%)
Rejection - Chronic Allograft (CAN)
10 (7%)
795 (79%)
805 (70%)
1 (7%)
105 (71%)
106 (65%)
Rejection - Hyperacute
3 (2%)
3 (<1%)
44 (31%)
14 (1%)
58 (5%)
5 (33%)
4 (3%)
Technical Problems
12 (9%)
5 (<1%)
17 (1%)
Glomerulonephritis
8 (6%)
63 (6%)
71 (6%)
Non Compliance
1 (1%)
38 (4%)
39 (3%)
10 (6%)
Other
33 (23%)
67 (7%)
100 (9%)
14 (9%)
141 (100%)
1007 (100%)
1148 (100%)
15 (100%)
148 (100%)
163 (100%)
ANZDATA Registry Annual Report 2013

39. Immunosuppressive Therapy - Primary Deceased Donor Graft 2005 - 2012
Figure 8.34
Australia
Immunosuppressive Therapy - Primary Deceased Donor Graft
Year
Aza
CyA
Tacrol
MMF
MPA
Sirol
Everolimus
Pred
Number of
Deceased Donor Grafts
Initial
treatment
2005
9 (3%)
131 (41%)
172 (54%)
299 (94%)
4 (1%)
17 (5%) -
308 (97%)
319
2006
155 (51%)
139 (45%)
260 (85%)
24 (8%)
3 (1%)
19 (6%)
296 (97%)
306
2007
2 (1%)
138 (48%)
140 (49%)
244 (85%)
36 (13%)
5 (2%)
285 (99%)
287
2008
137 (35%)
240 (61%)
364 (93%)
22 (6%)
389 (99%)
391
2009
62 (16%)
310 (82%)
356 (95%)
13 (3%)
375 (100%)
376
2010
66 (14%)
409 (86%)
426 (89%)
37 (8%)
1 (<1%)
477 (100%)
478
2011
54 (11%)
446 (87%)
300 (59%)
204 (40%)
505 (99%)
511
2012
22 (4%)
409 (77%)
343 (64%)
93 (17%)
6 (1%)
440 (83%)
533
Treatment at
12 months
23 (8%)
83 (29%)
172 (59%)
229 (79%)
21 (7%)
29 (10%)
262 (90%)
291
12 (4%)
94 (34%)
145 (52%)
216 (78%)
27 (10%)
21 (8%)
20 (7%)
259 (93%)
278
13 (5%)
86 (32%)
149 (56%)
189 (71%)
51 (19%)
12 (5%)
14 (5%)
252 (95%)
265
84 (23%)
251 (70%)
288 (80%)
37 (10%)
12 (3%)
9 (2%)
345 (96%)
361
18 (5%)
40 (11%)
283 (80%)
282 (80%)
39 (11%)
341 (96%)
354
24 (5%)
52 (11%)
370 (81%)
323 (71%)
82 (18%)
16 (4%)
11 (2%)
440 (97%)
454
26 (5%)
391 (81%)
223 (46%)
179 (37%)
8 (2%)
432 (89%)
485
24 months
76 (27%)
156 (55%)
220 (78%)
45 (16%)
238 (84%)
282
15 (6%)
81 (30%)
144 (53%)
207 (76%)
31 (11%)
25 (9%)
248 (92%)
271
79 (31%)
152 (59%)
181 (70%)
54 (21%)
243 (94%)
259
20 (6%)
80 (23%)
238 (68%)
275 (79%)
324 (93%)
350
23 (7%)
273 (79%)
254 (74%)
53 (15%)
11 (3%)
328 (95%)
344
24 (6%)
45 (10%)
328 (76%)
293 (68%)
71 (16%)
20 (5%)
14 (3%)
391 (91%)
432
Aza = Azathioprine
CyA = Cyclosporine
Tacrol = Tacrolimus
MMF = Mycophenolate Mofetil
MPA = Mycophenolic Acid (Enteric Coated)
Sirol = Sirolimus
Pred = Prednisolone
ANZDATA Registry Annual Report 2013

40. Immunosuppressive Therapy - Primary Deceased Donor Graft 2005 - 2012
Figure 8.35
New Zealand
Immunosuppressive Therapy - Primary Deceased Donor Graft
Year
Aza
CyA
Tacrol
MMF
MPA
Sirol
Everolimus
Pred
Number of
Deceased Donor Grafts
Initial
treatment
2005 -
32 (76%)
8 (19%)
41 (98%) 42
2006
26 (68%)
11 (30%)
34 (92%)
3 (8%)
37 (100%) 37
2007
43 (74%)
15 (26%)
57 (98%)
1 (2%)
58 (100%) 58
2008
30 (67%)
15 (33%)
42 (93%)
3 (7%)
45 (100%) 45
2009
39 (78%)
10 (20%)
49 (98%) 50
2010
32 (71%)
13 (29%)
2011
41 (71%)
17 (29%)
2012
33 (66%)
13 (26%)
46 (92%)
Treatment at
12 months
2 (5%)
21 (55%)
16 (42%)
33 (87%)
1 (3%)
35 (92%) 38
18 (53%)
15 (45%)
29 (88%)
3 (9%)
32 (97%) 33
3 (6%)
31 (60%)
20 (38%)
43 (83%)
2 (4%)
48 (92%) 52
21 (48%)
23 (52%)
39 (89%)
41 (93%) 44
24 (50%)
23 (48%)
48 (100%)
45 (94%) 48
16 (37%)
27 (63%)
41 (95%)
42 (98%) 43
22 (41%)
27 (50%)
45 (83%)
47 (87%) 54
24 months
2 (6%)
18 (50%)
17 (47%)
30 (83%)
29 (81%) 36
16 (50%)
28 (88%)
30 (94%) 32
29 (58%)
20 (40%)
41 (82%)
45 (90%)
20 (48%)
22 (52%)
37 (88%)
40 (95%)
21 (46%)
24 (52%)
45 (98%)
42 (91%) 46
15 (36%)
25 (60%)
Aza = Azathioprine
CyA = Cyclosporine
Tacrol = Tacrolimus
MMF = Mycophenolate Mofetil
MPA = Mycophenolic Acid (Enteric Coated)
Sirol = Sirolimus
Pred = Prednisolone
ANZDATA Registry Annual Report 2013

41. Antibody Use for Induction Immunosuppression
Figure 8.36
Antibody Use for Induction Immunosuppression
Australia and New Zealand
Number of Kidney Transplant Recipients
Receiving Each Agent by Year
(% Total New Transplants)
2008
2009
2010
2011
2012
Australia
Muromonab-CD3 -
1 (0.1%)
13 (1.5%)
Intravenous immunoglobulin
25 (3.1%)
28 (3.6%)
39 (4.6%)
42 (5.1%)
26 (3.1%)
Anti-CD25
740 (91.0%)
715 (92.5%)
800 (94.6%)
765 (92.7%)
569 (67.3%)
Rituximab
21 (2.6%)
17 (2.2%)
9 (1.1%)
10 (1.2%)
7 (0.8%)
T cell depleting polyclonal Ab
22 (2.7%)
40 (5.2%)
52 (6.1%)
33 (4.0%)
20 (2.4%)
Total new transplants
813
773
846
825
845
5 (0.6%)
New Zealand
1 (0.9%)
74 (60.7%)
63 (52.1%)
65 (59.1%)
114 (96.6%)
99 (91.7%)
1 (0.8%)
2 (1.7%)
3 (2.5%)
4 (3.7%)
122
121
110
118
108
ANZDATA Registry Annual Report 2013

42. Antibody Use as Treatment for Acute Rejection
Figure 8.37
Antibody Use as Treatment for Acute Rejection
Australia and New Zealand
Number of Kidney Transplant Recipients
Receiving Each Agent by Year
(% Total New Transplants)
2008
2009
2010
2011
2012
Australia
Muromonab-CD3
10 (1.2%)
12 (1.6%)
2 (0.2%) -
Intravenous immunoglobulin
89 (10.9%)
105 (13.6%)
92 (10.9%)
105 (12.7%)
41 (4.9%)
Anti-CD25
1 (0.1%)
Rituximab
24 (3.0%)
26 (3.4%)
15 (1.8%)
11 (1.3%)
6 (0.7%)
T cell depleting polyclonal Ab
19 (2.3%)
27 (3.5%)
41 (4.8%)
42 (5.1%)
20 (2.4%)
Total new transplants
813
773
846
825
845
Total transplants at risk
8064
8427
8893
9331
9723
New Zealand
10 (8.2%)
8 (6.6%)
4 (3.6%)
2 (1.6%)
7 (5.8%)
3 (2.5%)
3 (2.8%)
1 (0.8%)
1 (0.9%)
2 (1.7%)
12 (10.9%)
11 (9.3%)
4 (3.7%)
122
121
110
118
108
1422
1471
1514
1558
1591
ANZDATA Registry Annual Report 2013

43. Australia and New Zealand
Figure 8.38
Australia and New Zealand
Rejection Rates at Six Months Post Transplant
Donor Source
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
Living Donor
First graft
27.7%
21.6%
19.6%
21.1%
17.0%
16.8%
17.8%
17.5%
11.0%
Second and subsequent grafts
33.3%
34.8%
18.5%
34.3%
30.0%
24.3%
12.9%
10.3%
Deceased Donor
26.8%
22.8%
18.6%
16.3%
17.7%
22.0%
18.7%
20.0%
13.7%
25.0%
27.5%
31.7%
36.4%
32.8%
32.9%
36.5%
27.3%
19.2%
ANZDATA Registry Annual Report 2013

44. Primary Deceased Donor - Australia
Figure 8.39
Primary Deceased Donor - Australia
Recipient and Graft Survival
% [95% Confidence Interval]
Year of
Transplant
Survival
1 month
6 months
1 year
5 years
Recipient Survival
(n=609)
99 (97, 99)
96 (94, 97)
95 (93, 97)
85 (82, 88)
(n=601)
99 (98, 100)
88 (85, 90)
(n=606)
97 (95, 98)
87 (84, 89)
(n=559)
97 (96, 98)
87 (84, 90)
(n=615)
90 (88, 92)
(n=636)
(n=625)
89 (86, 91)
(n=678)
98 (97, 99)
91 (89, 93)
(n=854)
98 (96, 98) -
(n=1044)
100 (99, 100)
Graft Survival
93 (91, 95)
73 (69, 76)
95 (92, 96)
78 (74, 81)
92 (90, 94)
77 (74, 80)
96 (95, 98)
92 (89, 94)
80 (76, 83)
94 (92, 96)
82 (79, 85)
91 (88, 93)
79 (76, 82)
94 (92, 95)
81 (78, 84)
96 (95, 97)
95 (93, 96)
ANZDATA Registry Annual Report 2013

45. ANZDATA Registry Annual Report 2013
Figure 8.40a
ANZDATA Registry Annual Report 2013

46. ANZDATA Registry Annual Report 2013
Figure 8.40b
ANZDATA Registry Annual Report 2013

47. Graft and Patient Survival of Primary Grafts
Figure 8.43
Graft and Patient Survival of Primary Grafts
Deceased Donors - Australia and New Zealand
Graft Survival
Patient Survival
Time Period
1 year
5 yrs
10 yrs
15 yrs
20 yrs
(n=1149)
77.0%
57.4%
44.4%
34.2%
25.1%
58.2%
41.9%
30.3%
22.8%
14.6%
(n=1463)
81.0%
63.6%
49.4%
35.5%
26.2%
51.7%
36.0%
25.6%
17.7%
12.6%
(n=1595)
91.4%
75.1%
59.4%
45.9%
34.7%
63.3%
45.4%
32.1%
23.0%
16.2%
(n=1916)
92.1%
80.3%
64.5%
51.2%
39.6%
80.8%
65.8%
47.2%
32.9%
21.4%
(n=1906)
93.4%
83.9%
67.7%
53.2%
40.9%
85.0%
70.9%
50.7%
23.7%
(n=1779)
94.7%
86.1%
72.4%
57.1% -
88.6%
76.2%
58.6%
41.7%
(n=1850)
96.0%
89.1%
91.6%
64.0%
(n=1911)
96.7%
89.5%
92.3%
80.5%
(n=1675)
97.5%
94.9%
ANZDATA Registry Annual Report 2013

48. ANZDATA Registry Annual Report 2013
Figure 8.44
ANZDATA Registry Annual Report 2013

49. Second and Subsequent Deceased Donor - Australia
Figure 8.45
Second and Subsequent Deceased Donor - Australia
Recipient and Graft Survival
% [95% Confidence Interval]
Year of
Transplant
Survival
1 month
6 months
1 year
5 years
Recipient Survival
(n=121)
98 (94, 100)
98 (93, 99)
94 (88, 97)
86 (78, 91)
(n=107)
99 (94, 100)
97 (92, 99)
(n=109)
100
95 (89, 98)
(n=77)
99 (91, 100)
96 (88, 99)
95 (87, 98)
86 (76, 92)
(n=87)
99 (92, 100)
94 (87, 98)
92 (84, 96)
87 (78, 93)
(n=95)
99 (93, 100)
98 (92, 99)
95 (88, 98)
85 (76, 91)
(n=120)
97 (91, 99)
88 (81, 93)
(n=125)
96 (91, 98)
85 (76, 90)
(n=142)
99 (95, 100)
97 (93, 99)
95 (90, 98) -
(n=133)
Graft Survival
87 (79, 92)
85 (77, 90)
83 (76, 89)
70 (61, 78)
83 (75, 89)
78 (68, 84)
77 (67, 84)
61 (51, 69)
93 (86, 96)
89 (81, 94)
84 (76, 90)
73 (64, 81)
92 (83, 96)
88 (79, 94)
87 (77, 93)
68 (56, 77)
82 (72, 88)
67 (56, 75)
94 (86, 97)
72 (61, 80)
93 (87, 97)
89 (82, 94)
71 (62, 78)
93 (87, 96)
90 (84, 94)
94 (89, 97)
91 (85, 95)
ANZDATA Registry Annual Report 2013

50. ANZDATA Registry Annual Report 2013
Figure 8.46a
ANZDATA Registry Annual Report 2013

51. ANZDATA Registry Annual Report 2013
Figure 8.46b
ANZDATA Registry Annual Report 2013

52. Graft and Patient Survival of Second and Subsequent Grafts
Figure 8.47
Graft and Patient Survival of Second and Subsequent Grafts
Deceased Donors
Australia and New Zealand
Graft Survival
Patient Survival
Time Period
1 year
5 yrs
10 yrs
15 yrs
20 yrs
(n=158)
79.1%
55.7%
42.4%
33.5%
26.6%
58.9%
37.3%
27.2%
21.5%
14.6%
(n=284)
78.2%
57.4%
44.7%
31.3%
20.0%
44.0%
28.2%
20.4%
15.0%
8.1%
(n=417)
90.6%
74.8%
59.0%
46.8%
37.1%
48.9%
36.0%
25.6%
20.3%
14.2%
(n=458)
93.7%
79.2%
62.8%
47.3%
35.1%
70.1%
51.7%
34.4%
23.2%
13.9%
(n=374)
93.0%
82.6%
67.9%
54.0%
40.8%
78.3%
64.2%
44.1%
31.2%
21.0%
(n=296)
95.9%
86.1%
73.3%
60.0% -
81.8%
66.6%
44.3%
31.1%
(n=268)
86.2%
86.6%
51.5%
(n=343)
96.2%
87.9%
89.5%
73.1%
(n=217)
96.3%
93.4%
ANZDATA Registry Annual Report 2013

53. ANZDATA Registry Annual Report 2013
Figure 8.48
ANZDATA Registry Annual Report 2013

54. Primary Living Donor Grafts 1993 - 2012 Recipient and Graft Survival
Figure Australia
Year of
Transplant
Primary Living Donor Grafts
Recipient and Graft Survival
% [95% Confidence Interval]
1 month
6 months
1 year
5 years
Recipient Survival
(n=160)
100
99 (95, 100)
98 (94, 99)
94 (89, 97)
(n=186)
98 (95, 99)
97 (94, 99)
95 (90, 97)
(n=284)
99 (96, 99)
98 (96, 99)
96 (93, 98)
(n=320)
99 (98, 100)
94 (91, 96)
(n=410)
100 (98, 100)
99 (97, 100)
99 (97, 99)
95 (92, 97)
(n=419)
94 (92, 96)
(n=463)
97 (95, 98)
(n=557)
100 (99, 100)
(n=564)
98 (97, 99) -
(n=447)
Graft Survival
97 (93, 99)
96 (91, 98)
85 (78, 90)
93 (88, 96)
91 (86, 94)
90 (84, 93)
84 (78, 89)
97 (94, 98)
96 (94, 98)
87 (82, 90)
86 (82, 90)
96 (93, 97)
88 (85, 91)
88 (84, 91)
90 (87, 93)
ANZDATA Registry Annual Report 2013

55. Primary Living Donor Grafts 1993 - 2012 Recipient and Graft Survival
Figure New Zealand
Year of
Transplant
Primary Living Donor Grafts
Recipient and Graft Survival
% [95% Confidence Interval]
1 month
6 months
1 year
5 years
Recipient Survival
(n=160)
100
99 (95, 100)
98 (94, 99)
94 (89, 97)
(n=186)
98 (95, 99)
97 (94, 99)
95 (90, 97)
(n=284)
99 (96, 99)
98 (96, 99)
96 (93, 98)
(n=320)
99 (98, 100)
94 (91, 96)
(n=410)
100 (98, 100)
99 (97, 100)
99 (97, 99)
95 (92, 97)
(n=419)
94 (92, 96)
(n=463)
97 (95, 98)
(n=557)
100 (99, 100)
(n=564)
98 (97, 99) -
(n=447)
Graft Survival
(n=35)
91 (76, 97)
89 (72, 96)
74 (56, 86)
(n=46)
98 (86, 100)
76 (61, 86)
(n=57)
96 (87, 99)
95 (85, 98)
72 (58, 82)
(n=66)
95 (87, 99)
94 (85, 98)
82 (70, 89)
(n=83)
99 (92, 100)
88 (79, 93)
(n=88)
97 (90, 99)
95 (88, 98)
86 (77, 92)
(n=88)
91 (83, 95)
(n=120)
98 (94, 100)
98 (92, 99)
97 (91, 99)
84 (76, 90)
(n=118)
99 (94, 100)
97 (92, 99)
(n=101)
95 (87, 98)
ANZDATA Registry Annual Report 2013

56. ANZDATA Registry Annual Report 2013
Figure 8.51
ANZDATA Registry Annual Report 2013

57. ANZDATA Registry Annual Report 2013
Figure 8.52
ANZDATA Registry Annual Report 2013

58. ANZDATA Registry Annual Report 2013
Figure 8.53
ANZDATA Registry Annual Report 2013

59. ANZDATA Registry Annual Report 2013
Figure 8.54
ANZDATA Registry Annual Report 2013

60. Graft and Patient Survival of Primary Grafts
Figure 8.55
Graft and Patient Survival of Primary Grafts
Living Donors - Australia and New Zealand
Graft Survival
Patient Survival
Time Period
1 year
5 yrs
10 yrs
15 yrs
20 yrs
(n=21)
90.5%
81.0%
61.9%
52.4%
42.9%
85.7%
76.2%
61.5%
46.2%
20.5%
(n=107)
90.7%
78.5%
71.0%
61.7%
52.2%
81.2%
63.3%
49.9%
41.2%
31.1%
(n=241)
96.3%
85.4%
74.9%
64.8%
55.4%
82.8%
71.2%
59.3%
46.5%
35.9%
(n=230)
95.2%
87.8%
79.9%
71.1%
62.9%
90.8%
74.8%
60.5%
45.1%
35.0%
(n=431)
97.2%
89.2%
84.0%
74.5%
68.5%
91.8%
79.6%
65.3%
48.8%
32.0%
(n=766)
98.6%
94.7%
86.6%
76.8% -
94.5%
68.8%
52.1%
(n=1193)
98.5%
94.3%
95.9%
87.7%
72.4%
(n=1585)
96.7%
89.1%
(n=873)
99.0%
ANZDATA Registry Annual Report 2013

61. ANZDATA Registry Annual Report 2013
Figure 8.56
ANZDATA Registry Annual Report 2013

62. Graft and Patient Survival of Second and Subsequent Grafts
Figure 8.57
Graft and Patient Survival of Second and Subsequent Grafts
Living Donors - Australia and New Zealand
Graft Survival
Patient Survival
Time Period
1 year
5 yrs
10 yrs
15 yrs
20 yrs
(n=1)
100.0% -
(n=11)
81.8%
72.7%
63.6%
45.5%
36.4%
27.3%
(n=42)
97.6%
81.0%
78.6%
71.4%
51.9%
64.3%
59.5%
50.0%
40.5%
(n=31)
96.8%
83.9%
71.0%
64.5%
47.5%
87.1%
74.2%
58.1%
45.2%
29.0%
(n=38)
94.7%
73.3%
67.9%
51.3%
86.8%
41.2%
35.7%
24.7%
(n=74)
98.6%
89.2%
81.1%
93.2%
82.4%
68.9%
57.9%
(n=107)
98.1%
95.3%
85.7%
93.5%
85.0%
67.2%
(n=175)
98.3%
95.4%
82.1%
(n=87)
98.7%
95.2%
ANZDATA Registry Annual Report 2013

63. ANZDATA Registry Annual Report 2013
Figure 8.58
ANZDATA Registry Annual Report 2013