Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. CHAPTER 30 Thyroid and Antithyroid Drugs

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Thyroid Gland  Secretes three hormones essential for proper regulation of metabolism  Thyroxine (T 4 )  Triiodothyronine (T 3 )  Calcitonin  Located near the parathyroid gland  Which is responsible for maintaining adequate levels of calcium in the extracellular fluid

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Hypothyroidism: Deficiency in Thyroid Hormones  Primary: abnormality in the thyroid gland itself  Secondary: results when the pituitary gland is dysfunctional and does not secrete TSH  Tertiary: results when the hypothalamus gland does not secrete TRH, which stimulates the release of TSH

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Hypothyroidism  Cretinism  Hyposecretion of thyroid hormone during youth  Leads to cretinism: low metabolic rate, retarded growth and sexual development, possibly mental retardation

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Hypothyroidism (cont’d)  Myxedema  Hyposecretion of thyroid hormone during adulthood  Decreased metabolic rate, loss of mental and physical stamina, weight gain, loss of hair, firm edema, yellow dullness of the skin

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Hypothyroidism (cont’d)  Goiter  Enlargement of the thyroid gland  Results from overstimulation by elevated levels of TSH  TSH is elevated because there is little or no thyroid hormone in circulation

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Hypothyroidism (cont’d)  Common symptoms  Thickened skin  Hair loss  Constipation  Lethargy  Anorexia

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Hyperthyroidism: Excessive Thyroid Hormones  Caused by several diseases  Graves’ disease  Plummer’s disease (toxic nodular disease)  Multinodular disease  Thyroid storm (induced by stress or infection)

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Hyperthyroidism  Affects multiple body systems, resulting in an overall increase in metabolism  Diarrhea  Flushing  Increased appetite  Muscle weakness  Sleep disorders  Altered menstrual flow  Fatigue  Palpitations  Nervousness  Heat intolerance  Irritability

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Thyroid Preparations  levothyroxine (Synthroid, Levothyroidl)  Synthetic thyroid hormone T 4  liothyronine (Cytomel)  Synthetic thyroid hormone T 3  liotrix (Thyrolar)  Synthetic thyroid hormone T 3 -T 4 combined  Thyroid  Desiccated (dried) animal thyroid gland

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Mechanism of Action  Thyroid preparations are given to replace what the thyroid gland cannot produce to achieve normal thyroid levels (euthyroid)  Thyroid drugs work the same way as thyroid hormones

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Indications  To treat all three forms of hypothyroidism  Levothyroxine is the preferred drug because its hormonal content is standardized; therefore, its effect is predictable

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Indications (cont’d) Also used for thyroid replacement in patients whose thyroid glands have been surgically removed or destroyed by radioactive iodine in the treatment of thyroid cancer or hyperthyroidism

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Adverse Effects  Cardiac dysrhythmia is the most significant adverse effect  May also cause:  Tachycardia, palpitations, angina, hypertension, insomnia, tremors, headache, anxiety, nausea, diarrhea, menstrual irregularities, weight loss, appetite changes, sweating, heat intolerance, others

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Treatment of Hyperthyroidism  Radioactive iodine (I 131 ) works by destroying the thyroid gland  Surgery to remove all or part of the thyroid gland  Lifelong thyroid hormone replacement will be needed

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Treatment of Hyperthyroidism (cont’d)  Antithyroid drugs: thioamide derivatives  methimazole (Tapazole)  propylthiouracil (PTU)

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Antithyroid Drugs  Used to palliate hyperthyroidism and to prevent the surge in thyroid hormones that occurs after the surgical treatment or during radioactive iodine treatment for hyperthyroidism  May cause liver and bone marrow toxicity

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Nursing Implications  Assess for drug allergies, contraindications, potential drug interactions  Obtain baseline vital signs, weight  Cautious use advised for those with cardiac disease, hypertension, and pregnant women

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Nursing Implications (cont’d)  During pregnancy, treatment for hypothyroidism should continue  Fetal growth may be retarded if maternal hypothyroidism is untreated during pregnancy  Adjust dosage every 4 weeks to keep TSH at the lower end of the normal range

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Nursing Implications (cont’d)  Teach patient to take thyroid drugs once daily in the morning to decrease the likelihood of insomnia if taken later in the day  Teach patient to take the medications at the same time every day and not to switch brands without physician approval

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Nursing Implications (cont’d)  Teach patients to report any unusual symptoms, chest pain, or heart palpitations  Teach patients not to take OTC medications without physician approval  Teach patients that therapeutic effects may take several months to occur

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Nursing Implications (cont’d)  Antithyroid medications  Better tolerated when given with food  Give at the same time each day to maintain consistent blood levels  Never stop these medications abruptly  Avoid eating foods high in iodine (seafood, soy sauce, tofu, and iodized salt)

Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. Nursing Implications (cont’d)  Monitor for therapeutic response  Monitor for adverse effects