2001 THE REGISTRY OF THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION: EIGHTEENTH ANNUAL REPORT

2001 ACKNOWLEDGMENTS: We wish to extend our sincere thanks to the many thoracic transplant surgeons, physicians and data coordinators in transplant programs throughout the world whose timely and accurate submission of data has made these analyses possible.

2001 REGISTRY DATABASE

2001 REGISTRY DATABASE

2001 HEART TRANSPLANTATION * Numbers may be low due to incomplete reporting. Number of Transplants * * 12% 9% 6% 3% % donors % donors 50+ Percent of Donors by Age

2001 AGE DISTRIBUTION OF HEART RECIPIENTS ( ) % of Trnsplants % of Transplants

2001 ADULT HEART TRANSPLANTATION INDICATIONS

2001 AGE DISTRIBUTION OF PEDIATRIC HEART RECIPIENTS Number of Transplants

2001 PEDIATRIC HEART TRANSPLANTATION INDICATIONS BY AGE ( ) < 1 Year1-10 Years11-17 Years

2001 HEART TRANSPLANTATION ACTUARIAL SURVIVAL ( ) N=52,195 Half-life =9.1 years Conditional Half-life = 11.6 years

2001 ADULT HEART TRANSPLANTATION ACTUARIAL SURVIVAL All comparisons with are significant at p < Survival (%)

2001 ADULT HEART RE-TRANSPLANTATION ( ) 1 Year Patient Survival (%)

2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=38,943

2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=38,943 * * Latest period in cohort

2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=38,943

2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=38,943

2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=38,943

2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=26,250

2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=26,250

2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=26,250

2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=26,250

2001 PEDIATRIC HEART TRANSPLANTATION ACTUARIAL SURVIVAL ( ) All comparisons with <1 year significant at p <

2001 PEDIATRIC HEART TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=3,760 * Earliest period in cohort *

2001 PEDIATRIC HEART TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=3,760

2001 PEDIATRIC HEART TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=2,465 * Latest year in cohort *

2001 PEDIATRIC HEART TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=2,465

2001 PEDIATRIC HEART TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=2,465

2001 FUNCTIONAL STATUS Heart (April 1994-Dec. 2000)

2001 EMPLOYMENT STATUS Heart (US Data: April 1994-Dec. 2000)

2001 REHOSPITALIZATION POST HEART TRANSPLANTATION (April Dec. 2000)

2001 HEART TRANSPLANT MAINTENANCE IMMUNOSUPPRESSION % of Patients

2001 HEART TRANSPLANTATION Donor age versus Ejection Fraction yr 1 to yr 2

2001 POST-HEART TRANSPLANT MORBIDITY (April 1994-December 2000)

2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR CAV WITHIN 3 YEARS N=7,691

2001 ADULT HEART TRANSPLANTATION RISK FACTORS FOR CAV WITHIN 3 YEARS N=7,691

2001 MALIGNANCY POST-HEART TRANSPLANTATION (April 1994-December 2000) 1-Year Followup 5-Year Followup

2001 HEART TRANSPLANTS: CAUSE OF DEATH ( ) Timing of Death Cause of Death (%)

2001 HEART-LUNG TRANSPLANTATION

2001 ADULT HEART-LUNG TRANSPLANTATION INDICATIONS ( )

2001 HEART-LUNG TRANSPLANTATION ACTUARIAL SURVIVAL ( ) N=2,550 Half-life = 2.8 years Conditional Half-life = 8.2 years Survival (%)

2001 LUNG TRANSPLANTATION Mean Donor Age

2001 AGE DISTRIBUTION OF LUNG TRANSPLANTATION

2001 ADULT LUNG TRANSPLANTATION INDICATIONS ( ) Single Lung Bilateral/Double Lung

2001 PEDIATRIC LUNG TRANSPLANTATION AGE DISTRIBUTION ( ) Number of Transplants

2001 PEDIATRIC LUNG TRANSPLANTATION INDICATIONS ( )

2001 LUNG TRANSPLANTATION ACTUARIAL SURVIVAL ( ) Double lung: 1/2-life = 4.5 Years; Conditional 1/2-life = 7.9 Years Single lung: 1/2-life = 3.6 Years; Conditional 1/2-life = 5.7 Years All lungs: 1/2-life = 3.8 Years; Conditional 1/2-life = 6.3 Years

2001 ADULT LUNG TRANSPLANTATION ACTUARIAL SURVIVAL ( ) Comparison of vs was significant at p = 0.002

2001 PEDIATRIC LUNG/HRT-LUNG TRANSPLANTATION ACTUARIAL SURVIVAL ( )

2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=9,653 * Earliest period in cohort *

2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=9,653

2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=9,653

2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=9,653

2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 1 YEAR MORTALITY N=9,653

2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=5,050 * Earliest period in cohort *

2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=5,050

2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=5,050

2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR 5 YEAR MORTALITY N=5,050

2001 FUNCTIONAL STATUS Lung (April 1994-December 2000)

2001 EMPLOYMENT STATUS Lung (US: April 1994-December 2000)

2001 REHOSPITALIZATION POST LUNG TRANSPLANTATION (April December 2000)

2001 POST-LUNG TRANSPLANT MORBIDITY (April 1994-December 2000)

2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR BRONCHIOLITIS WITHIN 3 YEARS N=2,756 ** Latest year in cohort * Earliest year in cohort * **

2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR BRONCHIOLITIS WITHIN 3 YEARS N=2,756

2001 ADULT LUNG TRANSPLANTATION RISK FACTORS FOR BRONCHIOLITIS WITHIN 3 YEARS N=2,756

2001 MALIGNANCY POST-LUNG TRANSPLANTATION (April 1994-December 2000) 1-Year Followup 5-Year Followup

2001 LUNG TRANSPLANTS: CAUSE OF DEATH ( ) Timing of Death Cause of Death (%)