1. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. LUNG TRANSPLANTATION Pediatric Recipients

2. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS

3. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. AGE DISTRIBUTION FOR DONORS OF PEDIATRIC LUNG RECIPIENTS (1986-2001)

4. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS By Year of Transplant Number of Transplants 1 34 6 20 47 50 45 42 82 72 8586 6667 57 * Numbers may be low due to delayed reporting.

5. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS * Numbers may be low due to delayed reporting.

6. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG TRANSPLANTATION: Indications (1991-2001) DIAGNOSISAGE: < 1 YearAGE: 1-10 Years Cystic Fibrosis5534.2% PPH716.7%2414.9% Congenital Heart Disease1433.3%1710.6% IPF127.5% Pulmonary Vascular Disease614.3%63.7% Re-TX: Non-OB37.1%85.0% Re-TX: OB95.6% OB (Non-ReTX)63.7% Bronchiectasis21.2% COPD/Emphysema21.2% Other1126.2%1710.6%

7. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG TRANSPLANTATION Indications by Age (1991-2001) Age <1 Year Age 1-10 Years

8. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. DIAGNOSIS IN PEDIATRIC LUNG RECIPIENTS Age: 11-17 Years

9. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Procedure Type (1990-2001) P = 0.006

10. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Age Group (1990-2001) <1 Year: ½-life = 3.5 Years 1-10 Years: ½-life = 3.5 Years 11-17 Years: ½-life = 3.2 Years

11. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG TRANSPLANTATION Conditional Actuarial Survival by Age Group (1990-2001) <1 Year: ½-life = 7.1 Years 1-10 Years: ½-life = 5.9 Years 11-17 Years: ½-life = 5.4 Years

12. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Era (1988-2001) Survival (%)

13. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Procedure Type Diagnosis: PPH (1990-2001) P = 0.002

14. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG RECIPIENTS Functional Status (April 1994-December 2001)

15. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant (April 1994 - December 2001)

16. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG RECIPIENTS Induction Immunosuppression For follow-ups between October 1999 and December 2001

17. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Any Time During Follow-up Period For follow-ups between October 1999 and December 2001

18. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001

19. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001 1 Year Follow-up (N = 76)5 Year Follow-up (N = 39)

20. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up Report For follow-ups between October 1999 and December 2001

21. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. POST-LUNG TRANSPLANT MORBIDITY For Pediatric Recipients (April 1994-December 2000)

22. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. Freedom from Bronchiolitis Obliterans For Pediatric Lung Recipients (April 1994-December 2000)

23. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. Freedom from Renal Dysfunction* For Pediatric Lung Recipients (April 1994-December 2000) * Renal dysfunction = Creatinine > 2.5 mg/dl, dialysis or renal transplant

24. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. MALIGNANCY POST-LUNG TRANSPLANTATION FOR PEDIATRICS Cumulative Incidence for Survivors (April 1994-December 2001) Malignancy/Type1-Year Survivors5-Year Survivors No Malignancy288 (93.5%)45 (91.8%) Malignancy (all types combined)20 (6.5%)4 (8.2%) Malignancy Type Lymph184 Other2

25. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. Freedom from Malignancy For Pediatric Lung Recipients (April 1994-December 2000)

26. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival Based on Rejection within 1 st Year (1994-2000) Survival (%) P= 0.01

27. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG RECIPIENTS Relationship of Diabetes and Cystic Fibrosis Transplants: April 1994 – December 2000 Diagnosis Report of Diabetes Developing Between Transplant and 1st Year* Report of Diabetes Developing Between Transplant and 3rd Year** NoYesNoYes Cystic Fibrosis 103 70.1% 44 29.9% 29 55.8% 23 44.2% Other Diagnosis 137 97.3% 4 2.8% 53 94.6% 3 5.4% *p < 0.0001 **p < 0.0001

28. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG RECIPIENTS: Time Of Death (1988-2001)

29. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Cause of Death (1982-2001) Timing of Death