1. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. HEART TRANSPLANTATION Pediatric Recipients

2. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. AGE DISTRIBUTION OF PEDIATRIC HEART RECIPIENTS (Transplants: January 1982 - June 2002)

3. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. AGE DISTRIBUTION FOR DONORS OF PEDIATRIC HEART RECIPIENTS (Transplants: January 1982 - June 2002)

4. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. AGE DISTRIBUTION OF PEDIATRIC HEART RECIPIENTS By Year of Transplant Number of Transplants

5. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. NUMBER OF CENTERS REPORTING PEDIATRIC HEART TRANSPLANTS

6. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. DIAGNOSIS IN PEDIATRIC HEART TRANSPLANT RECIPIENTS (Age: < 1 Year)

7. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. DIAGNOSIS IN PEDIATRIC HEART TRANSPLANT RECIPIENTS (Age: 1-10 Years)

8. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. DIAGNOSIS IN PEDIATRIC HEART TRANSPLANT RECIPIENTS (Age: 11-17 Years)

9. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTATION Actuarial Survival (1/1982-6/2001)

10. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTATION Conditional Actuarial Survival (1/1982-6/2001)

11. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTATION Conditional Actuarial Survival for Recent Era (1/1998-6/2001)

12. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTATION Actuarial Survival by Era (1/1982-6/2001) Survival (%)

13. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTATION Actuarial Survival by Age Group For Diagnosis = Cardiomyopathy (Transplants: January 1998 - June 2001) Survival (%)

14. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTATION Actuarial Survival By Age Group For Diagnosis = Congenital Disease (Transplants: January 1988 - June 2001) Survival (%)

15. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/2001) Risk Factors For 1 Year Mortality N=2,055

16. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/2001) Risk Factors for 1 Year Mortality

17. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/2001) Risk Factors for 1 Year Mortality Recipient Age

18. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/2001) Risk Factors for 1 Year Mortality Donor Weight

19. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/2001) Risk Factors for 1 Year Mortality Bilirubin

20. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/2001) Risk Factors for 1 Year Mortality Recipient creatinine

21. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/2001) Factors Not Significant for 1 Year Mortality Recipient Factors: IV inotropes, PGE, ECMO, sternotomy, history of malignancy, weight, height, dialysis, recent infection, gender

22. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/2001) Factors Not Significant for 1 Year Mortality Donor Factors: Gender, clinical infection, history of diabetes, height, age, COD Transplant Factors: Donor/recipient weight ratio, CMV mismatch, ABO identical/compatible, year of transplant, repeat transplant, ischemia time, HLA mismatch, transplant center volume

23. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/1997) Risk Factors For 5 Year Mortality N=828

24. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/1997) Risk Factors for 5 Year Mortality

25. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/1997) Risk Factors for 5 Year Mortality Recipient Age

26. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/1997) Risk Factors for 5 Year Mortality Recipient creatinine

27. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/1997) Factors Not Significant for 5 Year Mortality Recipient Factors: IV inotropes, PGE, ECMO, history of malignancy, weight, height, dialysis, recent infection, gender, diagnosis, hospitalized at time of transplant, bilirubin

28. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/1997) Factors Not Significant for 5 Year Mortality Donor Factors: Gender, clinical infection, history of diabetes, height, weight, age, COD Transplant Factors: Donor/recipient weight ratio, CMV mismatch, ABO identical/compatible, year of transplant, repeat transplant, ischemia time, HLA mismatch, transplant center volume

29. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/1997) Risk Factors For 5 Year Mortality Conditional on 1 Year Survival N=630

30. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART RECIPIENTS Functional Status (Follow-ups: April 1994-June 2002)

31. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART RECIPIENTS Rehospitalization Post-transplant (Follow-ups: April 1994 - June 2002)

32. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART RECIPIENTS Induction Immunosuppression (Follow-ups: January 2000 - June 2002)

33. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART RECIPIENTS Induction Immunosuppression (Follow-ups: January 2000 - June 2002)

34. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART RECIPIENTS Maintenance Immunosuppression at Any Time During Follow-up Period For follow-ups between January 2000 through June 2002 NOTE: Different patients are analyzed in Year 1 and Year 5

35. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between January 2000 through June 2002 NOTE: Different patients are analyzed in Year 1 and Year 5

36. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART RECIPIENTS Maintenance Immunosuppression Drug Combinations at Time of Follow-up For follow-ups between January 2000 through June 2002 NOTE: Different patients are analyzed in Year 1 and Year 5

37. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. POST-HEART TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Prevalence in Survivors within 1 Year Post-Transplant (Follow-ups: April 1994-June 2002)

38. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. POST-HEART TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Prevalence in Survivors within 5 Years Post-Transplant (Follow-ups: April 1994-June 2002)

39. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. Freedom from CAV For Pediatric Heart Recipients (Follow-ups: April 1994-June 2002)

40. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. Freedom from CAV For Pediatric Heart Recipients (Follow-ups: April 1994-June 2002) Stratified by Age Group

41. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. SURVIVAL FOLLOWING REPORT OF CAV For Pediatric Heart Recipients (Follow-ups: April 1994-June 2002) Stratified by Age Group

42. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. Freedom from Severe Renal Dysfunction* For Pediatric Heart Recipients (Follow-ups: April 1994-June 2002) * Severe renal dysfunction = Creatinine > 2.5 mg/dl, dialysis or renal transplant

43. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. MALIGNANCY POST-HEART TRANSPLANTATION FOR PEDIATRICS Cumulative Prevalence in Survivors (Follow-ups: April 1994-June 2002) Malignancy/Type1-Year Survivors5-Year Survivors No Malignancy 1674 (98.1%) 434 (95.4%) Malignancy (all types combined) 32 (1.9%) 21 (4.6%) Malignancy Type Lymph2819 Other32 Type Not Reported1

44. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. Freedom from Malignancy For Pediatric Heart Recipients (Follow-ups: April 1994-June 2002)

45. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTATION Actuarial Survival Based on Prednisone Use (Transplants: April 1994 - June 2001) p = 0.002

46. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTATION Actuarial Survival Based on Rejection within 1 st Year (Transplants: April 1994 - June 2001) P = 0.01

47. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART RECIPIENTS Relationship of Prednisone Use and CAV (Follow-ups: April 1994 – June 2002) Prednisone Use at Discharge and at 1 Year Reported CAV between 1 st and 2 nd years post- transplant Reported CAV between 1 st and 3 rd years post- transplant YesNoYesNo Yes34 5.2% 617 94.7% 30 7.0% 397 93.0% No4 2.5% 154 97.5% 3 2.7% 110 97.3% p = 0.15 p = 0.08

48. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART RECIPIENTS Relationship of Rejection and CAV (Follow-ups: April 1994 – June 2002) Rejection During 1 st Year Reported CAV between 1 st and 2 nd years post- transplant Reported CAV between 1 st and 3 rd years post- transplant YesNoYesNo Yes24 5.8% 390 94.2% 19 6.9% 258 93.1% No6 1.6% 361 98.4% 8 3.2% 242 96.8% p = 0.003 p = 0.06

49. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART RECIPIENTS Incidence of Hypertension between 1 and 3 Years (Transplants: April 1993 - June 2002) Maintenance Immunosuppression at discharge and 1 year % HTN reported between 1 and 3 years P-value For Patients on drug For Patients not on drug Cyclosporine19.4%14.0%0.3 Tacrolimus17.3%18.6%0.8 Azathioprine22.2%14.1%0.1 MMF15.9%20.9%0.4 Rapamycin-19.4%- Prednisone28.5%6.4%<0.0001

50. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART RECIPIENTS Growth Following Transplantation: Height Stratified by Prednisone Use at Discharge and at 1 Year

51. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART RECIPIENTS Growth Following Transplantation: Weight Stratified by Prednisone Use at Discharge and at 1 Year

52. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/1997) Risk Factors For Developing CAV between 1 and 5 Years N=363

53. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANTS (1/1995-6/1997) Risk Factors for Developing CAV between 1 and 5 Years Recipient Age

54. 2003 ISHLT J Heart Lung Transplant 2003; 22: 610-72. PEDIATRIC HEART TRANSPLANT RECIPIENTS: Cause of Death (Deaths: January 1992 - June 2002) CAUSE OF DEATH 0-30 Days (N = 276) 31 Days - 1 Year (N = 231) >1 Year - 3 Years (N = 147) >3 Years - 5 Years (N = 93) >5 Years (N = 156) CAV2 (0.7%)21 (9.1%)32 (21.8%)35 (37.6%)54 (34.6%) ACUTE REJECTION25 (9.1%)66 (28.6%)39 (26.5%)15 (16.1%)20 (12.8%) LYMPHOMA5 (2.2%)8 (5.4%)2 (2.2%)14 (9.0%) MALIGNANCY, OTHER4 (1.7%)1 (0.7%)1 (1.1%)6 (3.8%) CMV1 (0.4%)5 (2.2%) INFECTION, NON-CMV38 (13.8%)37 (16.0%)11 (7.5%)5 (5.4%)5 (3.2%) PRIMARY FAILURE44 (15.9%)12 (5.2%)5 (3.4%)6 (6.5%)10 (6.4%) GRAFT FAILURE76 (27.5%)28 (12.1%)25 (17.0%)17 (18.3%)30 (19.2%) TECHNICAL17 (6.2%)3 (1.3%)2 (1.4%)1 (1.1%)2 (1.3%) OTHER7 (2.5%)7 (3.0%)8 (5.4%)4 (4.3%)8 (5.1%) MULTIPLE ORGAN FAILURE 24 (8.7%)23 (10.0%)3 (2.0%)1 (1.1%)1 (0.6%) RENAL FAILURE1 (0.4%) PULMONARY22 (8.0%)12 (5.2%)7 (4.8%)5 (5.4%)4 (2.6%) CEREBROVASCULAR19 (6.9%)7 (3.0%)6 (4.1%)1 (1.1%)2 (1.3%)