VERIS ™ by Electro-Diagnostic Imaging, Inc. Redwood City, California, USA First in Multifocal Electrophysiology and its Future

The Multifocal ERG

The Multifocal VEP

Traditional Visual Electrodiagnostic Testing EOG Full-field ERG ISCEV Standards + full control of Ganzfeld stimulation and data analysis for supplementary testing Pattern ERG Traditional VECP Fast quadrant VECP using m-sequence stimulation

Special Features All solid state engineering Continuous computer control of Flash intensity (max. > 100 cdsec/m 2 ) Flash chromaticity Flash duration Background luminance (max. >1000 cd/m 2 ) Background chromaticity 3 Red Fixation LEDs for EOG recording Integrated infrared eye camera Monitor electrode & fixation while recording VERIS™ Ganzfeld Stimulator All Ganzfeld recording uses fully automated protocols that can be customized with VERIS Science software

System works with any laser or inkjet printer Wheelchair accessible stimulator Wheelchair accessible stimulator Software controlled amplifier system (up to 16 channels) Isolation Transformer FMS II Stimulator and Fundus/Eye Camera Ssolid State (RGB color) Ganzfeld Stimulator with IR Eye Camera Complete VERIS™ system using the FMSIII (fundus monitoring stimulator)

Monitoring the Patient’s Fixation (Essential for Multifocal Testing) Eye Camera   Fundus Camera Can monitor fixation stability Monitors position of the stimulus array on the fundus

Incorporates: High resolution color microdisplay for stimulation Eye camera for alignment Fundus camera for fixation monitoring FMS III Stimulator with Eye and Fundus Monitoring during Stimulation Stimulated field ~ 50 0 standard

Complete VERIS™ system using 9” stimulator with integrated refractor/camera

21” Ultra High Luminance Stimulator with Eye Camera/Refractor Stimulated field ~ 50 0 standard

Conventional and Multifocal stimulation of Retinal Preparation through Microscopes High resolution microdisplay (1280 x 1024) Fast Response time (<50 µs) RGB color High light intensity capability Attaches to camera port with C-mount Features:

Kernels v/s Responses and some New Developments in VERIS 6 The m-sequence technique provides a series of kernels. Most of us do not have an intuitive understanding of these mathematical constructs. However, from them we can easily predict the results of many experiments such as double and multi-flash tests from a single m-sequence stimulus series. This is illustrated in the following few slides that are derived from a single record of 54 seconds duration using m-sequence Ganzfeld flash stimulation. Ask for a Demo with VERIS!

First Order Kernel Second Order Third Order Forth Order Test Test: Ganzfeld standard flash Record length 54 s Base Inteval 20 ms Kernel Series Not all kernels used in the analysis are shown here

First Order Second Order Third Order Forth Order Test Test: Ganzfeld standard flash Record length 54 s Base Inteval 20 ms Kernel Series Not all kernels used in the analysis are shown here

First Order Second Order Third Order Forth Order Test Test: Ganzfeld standard flash Record length 54 s Base Inteval 20 ms Kernel Series Not all kernels used in the analysis are shown here

First Order Second Order Third Order Fourth Order Test Test: Ganzfeld standard flash Record length 54 s Base Inteval 20 ms Kernel Series Not all kernels used in the analysis are shown here

Ganzfeld standard flash Record length 54 s, Base Interval 20 ms Single Flash Response Double Flash Responses Interval 60 ms Interval 20 ms Response Sequence Derived from the Kernel Series Interval 40 ms

Ganzfeld standard flash Record length 54 s Base Interval 20 ms Single Flash Response Double Flash Responses Interval 60 ms Interval 20 ms Response Sequence Derived from the Kernel Series Interval 40 ms

Ganzfeld standard flash Record length 54 s Base Inteval 20 ms Single Flash Response Double Flash Responses Interval 60 ms Interval 20 ms Response Sequence Derived from the Kernel Series Interval 40 ms

Ganzfeld standard flash Record length 54 s Base Inteval 20 ms Single Flash Response Double Flash Responses Interval 60 ms Interval 20 ms Response Sequence Derived from the Kernel Series Interval 40 ms

Single Flash (transient) Response Flicker Response From the Same Short Record

Kernels v/s Responses The same kernel synthesis can be performed on multifocal records. The following three slides were all derived from the same single 7 minute record from a normal subject. Ask for a Demo with VERIS!

First Order Kernel Isolated Focal Flash Response

Multifocal Flicker 37 Hz

Multifocal Flicker 75 Hz

The Optic Nervehead Component (ONHC) for Evaluating Ganglion Cell and Optic Nerve Function

Direct Response First Induced Component Second Induced Component Response Epoch Used in this Study Feature contributed by the ONHC Fig. 1 Optic nerve head

Normal Subject

The ONHC in Primary Open-Angle Glaucoma

hb mfofo.100hz.600 os

The Multifocal VEP

Dartboard Pattern Stimulus for mfVEP Recording with Various Numbers of Sectors

VERIS ™ 6 Software Four Levels 1.BASIC Simple mfERG 2.CLINIC All Pre-programmed Tests 3.SCIENCE CLINIC + full stimulation and analysis creation and editing capability 4.PRO SCIENCE + advanced kernel synthesis

Apple OS X Platform Exceptionally stable VERIS data can be stored automatically to any local, network, or Internet-accessible storage device Choice of open or password-protected file locking of data, analysis settings, and recording settings files Easy creation of pdf copies of reports for electronic medical records or communications without additional (3rd party) software Easy to learn and fun to use!

Real-time Internet support from EDI Available to all VERIS users by appointment Real-time monitoring and control of your VERIS system from our California office for training and troubleshooting at your location. Fully encrypted with security controls and session transcripts to ensure privacy of medical information Supplied through Motorola Corp. eCare platform Requires only fast Internet connection