Did You Know? As you age, your skin is depleted of the energy required to fight free radicals and protect against oxidative stress, resulting in a loss of vitality and radiance. Find out how a unique combination of antioxidants can help fight free radical damage and promote cellular energy production.

Objectives From this presentation you should have an understanding of the following: Key benefits and key ingredients of Celltrex ® CoQ10 Complete. Role of coenzyme Q10 and the protective antioxidant network in promoting cellular energy. Usage and regimen recommendations.

Basic Skin Care Beautiful skin is determined by the healthy structure and proper function of components within the skin. To maintain beautiful skin and slow the rate at which it ages, the skin must be supplemented and protected.

Free Radicals and Antioxidants Free radicals are unstable, highly reactive molecules that damage the skin, leading to side effects associated with skin ageing, such as lines and wrinkles, dullness and sagging. Antioxidants are nature’s defence against the damaging effects of free radicals, guarding cellular structures and DNA against ageing free radicals.

The Antioxidant Network Antioxidants work optimally as a network to protect cellular health and viability. Carotenoids are known as “blotters” and provide the first line of defence by absorbing a large part of the free radicals’ load. Vitamin C Vitamin E Vitamin C CoQ10 (Carotenoids) In addition to carotenoids, the powerful “ redox ” (regenerating) antioxidants CoQ10 and vitamins C and E play a significant role in the antioxidant network.

Nu Skin ® Celltrex ® CoQ10 Complete Scientists understand that free radicals are the root cause of ageing. They damage cell structures, compromising the skin’s ability to function optimally. Fighting free radicals and repairing past damage is an essential part of preventing skin ageing and maintaining a youthful appearance. Skin requires adequate amounts of cellular energy to continue the fight against ageing. For this reason, many cosmetic companies have developed products containing the powerful anti-ageing ingredient CoQ10.

Nu Skin ® Celltrex ® CoQ10 Complete In addition to being a powerful antioxidant, CoQ10 can also act as a coenzyme* in cellular energy production, which is essential for healthy, youthful looking skin. Unfortunately, many CoQ10-containing products on the market today do not take advantage of the full potential of CoQ10. *What is a coenzyme? A non-protein organic substance, usually a vitamin or mineral, that combines with a specific protein to form an active enzyme.

Nu Skin ® Celltrex ® CoQ10 Complete Based on the scientific studies conducted by Dr. Lester Packer, the world’s foremost antioxidant research scientist, Nu Skin has developed a product that protects and promotes energy production while harnessing the full power of CoQ10.

Celltrex ® CoQ10 Complete Celltrex ® CoQ10 Complete promotes cellular energy production, allowing your skin to rebound beautifully from daily oxidative stress for a radiant, youthful appearance. Only this patent pending serum combines coenzyme Q10 with a protective antioxidant network of colourless carotenoids and vitamins C and E for optimal CoQ10 bioactivity. Celltrex ® CoQ10 Complete—Youthful Energy You Can See.

Key Benefits a) Promotes essential cellular energy production for a radiant, youthful appearance. b) Supplies an exclusive combination of CoQ10, colourless carotenoids and vitamins C and E for a complete antioxidant network of protection against skin-damaging free radicals. c) Enhances CoQ10 bioactivity for a healthier, more youthful appearance. d) Provides a daily antidote to the signs of ageing by increasing energy levels within the skin.

Key Ingredient Coenzyme Q10 (CoQ10)—an essential antioxidant found in your cells that functions as a coenzyme in generating cellular energy. CoQ10 helps maintain a healthier, more youthful appearance and can also act as a free radical fighter and regenerator of other antioxidants. O H 3 CO CoQ10 H 3 CO CH 3 O H 10

Additional Key Ingredients Colourless carotenoids —function as blotters, absorbing a significant number of attacking free radicals. In this way, carotenoids provide direct protection, enabling other antioxidants, such as CoQ10, to perform their critical functions. O CH 3 OH Vitamin E Vitamins E and C —vitamin E protects healthy cell membranes from oxidative free radical damage. Vitamin C works synergistically with vitamin E to quench free radicals and also works to regenerate vitamin E. Like CoQ10, vitamins E and C function best in a complete antioxidant network.

Key Benefits and Ingredients Supported

Key Benefit Supported a) Promotes essential cellular energy production for a radiant, youthful appearance. Highly concentrated within the cell’s energy-generating mitochondria, CoQ10 plays an important role as a coenzyme in generating cellular energy. Fortified with a reserve of energy, cells are able to more efficiently protect against the environmental stress that dulls the skin and leads to ageing. With adequate energy to fight free radicals and their ageing effects, the skin has a more radiant, youthful appearance.

Key Benefit Supported b) Supplies an exclusive combination of colourless carotenoids and vitamins C and E for a complete antioxidant network of protection against skin-damaging free radicals. CoQ10 functions as either an energy coenzyme or, if other antioxidants are unavailable, as a free radical fighter. Ideally, CoQ10 will function as an energy coenzyme. When CoQ10 is protected by a complete antioxidant network, it will be available to generate energy and promote healthy looking, more vibrant skin. Celltrex ® CoQ10 Complete is specifically formulated with vitamins C and E to help provide a complete and protective antioxidant network for maximum cellular energy.

Key Benefit Supported c) Enhances CoQ10 bioactivity for a healthier, more youthful appearance. When CoQ10 is protected by a complete antioxidant network, including colourless carotenoids with vitamins C and E, it is free to function as an energy coenzyme. Cells are provided with a reserve of energy to quench free radicals and repair oxidative damage. This abundance of energy results in a healthier, more youthful appearance as cellular processes function at ideal levels.

Key Benefit Supported d) Provides a daily antidote to the signs of ageing by increasing energy levels within the skin. Scientists understand that the oxidative damage caused by free radicals breaks down key cellular components. This breakdown results in the decline of vital protective processes, including the cell’s ability to generate endogenous antioxidants and internal cellular rejuvenation. CoQ10 is necessary to help generate the cellular energy required to create and protect the proteins responsible for the appearance of youthful skin.

Scientific Studies The ability of colourless carotenoids to protect the energy producing potential of CoQ10 was investigated in two separate studies conducted by a third-party laboratory. Study 1 : Conducted on fibroblast cells in vitro. Results are summarised in the following two slides. Study 2 : Focuses on the ability of colourless carotenoids to protect CoQ10 availability when exposed to the negatively charged ion (anion) potassium hydroxide (KOH). This ion can have the same oxidative effects as free radicals on CoQ10 and mitochondria. Results are summarised in the slides following Study 1.

Level of Cellular Stress NoTreatment Control Group Study 1: Synergistic Effects of CoQ10 and Colourless Carotenoids on Cellular Stress in Fibroblasts The first bar (Control Group) represents human fibroblasts not stressed with interleukin-1 (IL-1), a pro-inflammatory cytokine. The second bar (No Treatment) represents human fibroblasts stressed with IL-1, but left unprotected by CoQ10 or colourless carotenoids. The third bar (CoQ10) represents human fibroblasts stressed with IL-1 and protected by CoQ10. The fourth bar (Colourless Carotenoids) represents human fibroblasts stressed with IL-1 and protected by colourless carotenoids. The fifth bar (CoQ10 and Colourless Carotenoids) represents human fibroblasts stressed with IL-1 and protected by both CoQ10 and colourless carotenoids.

CONCLUSIONS The results suggest that a combination of CoQ10 and colourless carotenoids is more effective in reducing the effects of cellular stress (often caused by UV radiation and environmental pollutants) than either one alone. Carotenoids alone inhibited cellular stress indicators by 47 percent; however, the combination of CoQ10 and colorless carotenoids showed almost a 70 percent inhibition in cellular stress indicators. Study 1: Synergistic Effects of CoQ10 and Colorless Carotenoids on Cellular Stress in Fibroblasts

The chart to the left shows the effect of potassium hydroxide (KOH), a strong base that oxidatively degrades the bioavailability of CoQ10, with and without the protection of colourless carotenoids. The first bar (Control) represents the base bioavailability of CoQ10. The second bar (KOH) represents the bioavailability of CoQ10 in the presence of KOH, an oxidative agent. The third bar (Carotenoids and KOH) represents the bioavailability of CoQ10 in the presence of KOH and colourless carotenoids. + KOH Study 2: CoQ10 Bioavailability in the Presence of KOH and Colourless Carotenoids CoQ10 Bioavailability

CONCLUSIONS The results suggest that colourless carotenoids are able to protect CoQ10 from oxidative degradation caused by environmental stressors (free radicals from UV radiation and environmental pollutants). This enhanced protection promotes CoQ10 bioavailability, enabling cells to produce optimal levels of cellular energy. With adequate energy stores cells are able to maintain a healthy and more youthful appearance. Study 2: CoQ10 Bioavailability in the Presence of KOH and Colourless Carotenoids

Usage and Regimen Recommendations

Usage Use in the morning after cleansing and toning to protect against free radical exposure throughout the day. Apply Celltrex ® Ultra Recovery Fluid in the evening for optimal nighttime recovery. Dispense a few drops on fingertips and gently smooth over face and neck. Follow with the Nu Skin ® moisturiser that best meets your skin’s needs.

Regimen Recommendation Celltrex ® CoQ10 Complete and Celltrex ® Ultra Recovery Fluid work synergistically to provide your skin the most powerful protection against environmental oxidation for radiant, youthful looking skin. Morning Celltrex ® CoQ10 Complete Promotes cellular energy for optimal cell function and protection; helps maintain a healthy, youthful appearance. Evening Celltrex ® Ultra Recovery Fluid Counteracts oxidative stress and inflammation for nighttime rejuvenation and recovery.

Supplement Your Skin’s Cellular Energy Inside and Out When used together, topical and internal CoQ10 supplementation can have a synergistic reserve effect. This provides extended protection to the skin against energy loss and environmental vulnerability. Energise Your Skin—Inside and Out.

Nutricentials ™ are topically applied nutrient building blocks proven by research to naturally enhance the healthy appearance of skin. These essential nutrients found in local diets around the world are delivered to the skin in their purest, most concentrated form. Nu Skin ® Celltrex ® CoQ10 Complete contains the Nutricentials ™ ingredient, colourless carotenoids, which play an important role in the antioxidant network. Working with vitamins E and C, colourless carotenoids help protect and maintain the bioavailability of the energy producing nutrient CoQ10. ™

Review Nu Skin ® Celltrex ® CoQ10 Complete with coenzyme Q10, the protective antioxidant network of colourless carotenoids, and vitamins C and E allows your skin to rebound beautifully from daily oxidative stress for a radiant, youthful appearance. CoQ10 —a naturally occurring antioxidant found in cells that functions as a coenzyme in generating cellular energy. Colourless carotenoids —protects by providing a protective antioxidant network to ensure optimal CoQ10 bioactivity for a radiant, firmer appearance. Vitamins E and C —two powerful redox (regenerating) antioxidants that contribute to cellular health and longevity. Like CoQ10, they function best in a complete antioxidant network.