Vascular Disorders Monique Killins Roll # 1043 Windsor University School of Medicine

Introduction Vascular Disorders occur because of inflamed blood vessels ​ Inflammation: neutrophils, macrophages and lymphocytes

Symptoms Fever ​ Fatigue ​ ​ Night sweats ​ Muscle and joint pain ​ Loss of appetite ​ Weight loss ​​

Signs ​ Blood Test: ​ high WBCs, high platelets, low red blood cells, high ESR ​ Urine Test : ​ red blood cells, protein (assess kidney function) ​ Biopsy displaying signs of inflammation ​

Causes ​ Idiopathic ​ Infection: Hepatitis B, C ​ Drugs: birth control pills, erythromycin ​ ​ Toxins ​​

Churg-Strauss Syndrome Asthma ​ Allergic problems ​ Chronic nasal inflammation ​ Inflammation damaging skin, nerves, lungs and kidney ​ SYMPTOMS ​ COUGH ​ FACIAL PAIN ​ RASHES ​ SHORTNESS OF BREATH ​

Giant Cell Arteritis large and medium blood vessels ​ head, neck, upper body and eye vessels affected ​ SYMPTOMS ​ SCALP PAIN ​ JAW PAIN ​ BLURRED VISION

Wegener Granulomatosis small and medium sized blood vessels ​ inflammation of upper airway, lungs and kidney ​ SYMPTOMS ​ CHRONIC SINUSITIS ​ NOSEBLEEDS ​ CHEST PAIN ​ COUGH ​

Management Treat primary problem ​ Corticosteroids:prednisone ​ Immunosuppressants :cyclophosphamide, rituximab, methotrexate ​

Complications Hemorrhage ​ Kidney Failure ​ Treatment Complications: ​ decreased bone density, high blood pressure, cataracts, weight gain, diabetes; immunosuppressant related infection

Case Study A 26-years-old man was referred with decreased visual acuity for one week in the left eye. Headache was a accompanying complaint and he was overwhelmed by oral ulcers. On ophthalmologic examination, he had a visual acuity of 16/20 on both eyes. Color vision tested with Ishihara plates was 12/12. The anterior segment was normal and intraocular pressure measured with applanation tonometer revealed 12 mmHg on the right eye and 11 mmHg on the left eye.

References _joint_and_muscle_disorders/vasculitic_di sorders/overview_of_vasculitis.html ​ ​ mation/chronicinflam.htm ​ rticle/ htm ​ ​ Windsor University Pathology I Lecture ​ Google Images ​