Unit 5 Part 1: Is cancer in our genes? Bell Ringer Unit 5 Part 1: Is cancer in our genes? Identify the organelle that stores our genetic information Yesterday we learned that the BRCA1 protein helps prevent cells from becoming cancerous. What is the effect of having a mutation like Theresa’s in the BRCA1 gene?

How is our genetic information stored? Levels of Genetic Organization Largest Smallest Nucleus Organelle that contains the DNA

How is our genetic information stored? Levels of Genetic Organization Largest Smallest Nucleus Organelle that contains the DNA Chromosome Large coiled bundles of DNA

How is our genetic information stored? Levels of Genetic Organization Largest Smallest Nucleus Organelle that contains the DNA Chromosome Large coiled bundles of DNA Gene section of DNA that codes for a certain protein and leads to a certain trait

How is our genetic information stored? Levels of Genetic Organization Largest Smallest Nucleus Organelle that contains the DNA Chromosome Large coiled bundles of DNA Gene section of DNA that codes for a certain protein and leads to a certain trait Nucleotide/ Base The building blocks of DNA (A, T, C, & G)

How is our genetic information stored?

Base Pair Rule A + T (Adenine + Thymine) C + G (Cytosine + Guanine)

Is it a Chromosome, Gene, or Nucleotide? Circle one and explain how you know.

Yesterday we learned about a segment of nucleotides that serves as instructions about how to make the BRCA protein. This can be called a… chromosome gene nucleotide How do you know?

A scientist used an electron microscope and a laser to slice a nucleus in half and observe its contents. He saw 23 bundled structures inside. These can be called… chromosomes genes nucleotides How do you know?

These lines point to… chromosomes genes nucleotides How do you know?

Why do we look the way we do? determines determines A-T-C-C-G-A DNA Sequence Protein Made Trait

So does everyone have the same sequence of DNA? Why do we look the way we do? determines determines A-T-C-C-G-A DNA Sequence Protein Made Trait So does everyone have the same sequence of DNA?

Crazy Fact: Each one of your cells has the EXACT same sequence of DNA Nerve Cell Stomach Cell

How is it possible?! Genes that are needed in a cell are activated (turned on) and genes that are not needed are deactivated (turned off). Nerve Cell Stomach Cell

Stop and Jot DNA is made up 4 building blocks- A, T, C, G. Is the sequence (order) of these nucleotides the same in your cells as they are in the person sitting next to you? Why or Why not? Is the sequence of nucleotides the same in your eye cell as it is in your liver cell? Explain why or why not.

Partner Practice 1. Which statement describes one characteristic of this molecule? (1) It is the template for the replication of genetic information. (2) Organic catalysts are made up of these molecules. (3) It is different in each cell of an organism. (4) Cell membranes contain many of these molecules.

Partner Practice 2. Which diagram represents the relative sizes of the structures listed below?

Partner Practice A human liver cell is very different in structure and function from a nerve cell in the same person. This is best explained by the fact that different genes function in each type of cell (2) different DNA is present in each type of cell (3) liver cells contain fewer chromosomes than nerve cells (4) different DNA is present in each type of cell