CENTER FOR PROCESS ANALYTICAL CHEMISTRY UNIVERSITY OF WASHINGTON, SEATTLE

 Provides a Forum for Multidisciplinary Participation in Process Analytical Technology  Established in 1984, the Objective of the Center is to Address Challenges in Real-Time Analysis and Process Control CPAC is a Consortium of Industrial Sponsors, National Laboratories and Government Agencies

CPAC Core Research Areas  Chemometrics  Sensors  Spectroscopy / Imaging  Chromatography  Micro-Flow Analysis  Process Control 22 research projects

Multidisciplinary  Chemistry  Chemical Engineering  Electrical Engineering  Bioengineering  Applied Physics  Forestry  Food Science & Engineering  Health Sciences Presently at 5 Universities

CPAC Industrial Sponsors Air Products Agilent Amgen Amersham Bioscience Ashland Aventis Axsum Baxter Healthcare Boeing Bristol-Myers Squibb Cargill - CPC Systems Chevron Texaco Dow Chemical Dupont Eli Lilly ExxonMobil Chemical Goodyear Tire & Rubber Honeywell Inc. ICI Kaiser Optical Systems Kraft Foods Master Foods Merck & Co. Metso Automation Miller Brewing Parker Hannifin Phillips Petroleum Swagelok Systematix Controls 3M NIST Westinghouse Savannah River PNNL for

Sponsor Focus Groups  Chemicals & Materials  Food & Consumer Products  Bio Tech / Pharmaceuticals  Oil & Petrochemicals

CPAC Activities Graduate Education Summer Institute Semiannual Sponsor Meetings Technical Workshops Visiting Scientist Program IFPAC, Pittcon, ISA PAT

ISAExpo October 2003: Houston, TX

CPAC CONTINUES TO REFLECT ON INDUSTRY NEEDS  SAMPLING  MIXING EFFICIENCY  CLEANING VALIDATION  PARTICLE SIZING  CHEMICAL COMPOSITION (molecular, spatial)  COATING CONSISTENCY  VAPOR CHARACTERIZATION  VISCOSITY / RHEOMETRICS  MOISTURE CONCENTRATION  BIOASSAY

A CPAC STRATEGIC RESEARCH OBJECTIVE IN 1996  DEVELOP VERSATILE MICRO- ANALYTICAL SYSTEMS (VMAS) THAT WILL ENHANCE PROCESS OPTIMIZATION, MONITORING, MODELING AND CONTROL

SOME RELEVANT CURRENT CPAC RESEARCH TO SUPPORT VMAS MICRO-LC SURFACE TENSION DETECTION GCxGC FRINGE FIELD SENSORS VAPOCHROMIC SENSORS RAMAN GRATED LIGHT REFLECTIVE SPECTROSCOPY REFLECTOMETRY FLOW-THROUGH PARTICLE ANALYZER SURFACE PLASMON RESONANCE MINI-NMR ULTRASOUND DATA HANDLING

CPAC INITIATIVES OPEN -NEW SAMPLING AND SENSOR INITIATIVE (NeSSI) -CONNECTIVITY INTIATIVE (ConnI) -CHEMOMETRICS ON-LINE INITIATIVE (COPA) CLOSED -MICRO-INSTRUMENTATION FOR HIGH THROUGHPUT EXPERIMENTATION -FERMENTATION MONITORING AND CONTROL (FermI)

MISSING LINK IDENTIFIED IN 1997, BRUCE KOWALSKI WROTE AN ARTICLE THAT QUESTIONED WHO WOULD SUPPORT THE DEVELOPMENT OF NEW MEASUREMENT TECHNOLOGY INTO A USEFUL INSTRUMENT.

The NeSSI Platform Will Also Become the Base for a Micro-Analytical Lab ‘A DEVELOPMENT PLATFORM’ NMR MS NIR RAMAN LC GC FIA Particle Size Viscosity Moisture Conductivity Mass Flow

NeSSI with an Array of Micro- Analytical Techniques will Impact Many Industries Process Control Process Optimization Product Development

This will provide Real Time Analytical for: Molecular Characterization (composition conformation) Validation of sample conditions Analytical Method development Improved sample turn-around time, cost Expanded use can be envisioned