1. NeSSI™ - Gen III Finding the Longitude – the microAnalytical Vision Rob Dubois CPAC/NeSSI™ Workshop – PM Session Seattle, Washington, USA May 6, 2004 “the best way to predict the future is to create it”

2. rnd/May 6, 20042 Who is John Harrison? Like squaring the circle or inventing a perpetual motion machine, the phrase 'finding the longitude' became a sort of catchphrase for the pursuits of fools and lunatics. Many people believed that the problem simply could not be solved. 1693-1776 Courtesy of ©NMM London.

3. rnd/May 6, 20043 Today’s Analytical System The Technology of Last Resort! More of an “art” than a “science” Expensive –up to 60% of costs after purchase Require large sample & utility usage Skilled maintenance staff required Courtesy of Dow Chemical, Freeport, TX

4. rnd/May 6, 20044 Smaller Size Higher System Reliability Time Ad Hoc Installations Engineered Analyzer House By-Line/In-Line Technology Explosion! Fast networks/computers Robust/miniature electronics Lab-on-a-chip; optics; wireless Fiber optic sensors What does the Market Need? Reliable, rugged, low cost & fast What are the Critical Issues? Development Cost Technology hurdles Market acceptance 1938 2000 MicroAnalytical & Process Analytical

5. rnd/May 6, 20045 The Ideal microAnalytical Device for Process Analytical (1/4) Has global electrical (hazardous) Certifications Embedded multi-drop digital protocol Plug & Play (self-identifies) Robust (> 99.9% uptime) –Embedded smarts/Self-diagnostics –minimum or no moving parts –modular replacement Low cost (c. <$5K) –<$1K “disposable” Embedded documentation

6. rnd/May 6, 20046 The Ideal microAnalytical Device for Process Analytical (2/4) Multi-Component Analysis –multi-component: GC, MS, SPECTROSCOPY –unimolecular sensors Suitable for operating as a Functional Clusters –pH, DO2, Conductivity: “water package” –NOx, O2, CO: “CEMS package” Gas and/or Liquid Service Wide Sensitivity: “Configurable” rangeability –PPB, PPM, PERCENT

7. rnd/May 6, 20047 The Ideal microAnalytical Device (3/4) Fast (continuous) Response (< 10 seconds) Physically small in size Low Power (for intrinsic safe operation) Impeccable selectivity –under both normal & upset conditions 316L SS (typ.) or process compatible Self Correcting (drift compensation within limits) –Ambient temp/pressure changes –Sample pressure/flow/temp changes Self-checking/calibrating Low/No Utility or Reagent Usage

8. rnd/May 6, 20048 The Ideal microAnalytical Device (4/4) (conditioned sample) Typ. Pressure: –(typical) vacuum to 150 psig –(higher) vacuum to 500 psig Typ. Temperature: -20 to 80 C. Flow (gas) –3 to 200 cc/min and 3 to 2,000 cc/min Flow (liquid) –1 to 300 cc/min and 1 to 1,500 cc/min

9. rnd/May 6, 20049 Analytical Sensors (Gen III) SAM Fiber Optic AT One sensor per component “lab on a chip” One Sensor measuring Multiple Analytes V T P A

10. rnd/May 6, 200410 NeSSI™: Enabler for MicroAnalytical (the “rail” concept) Standard Mechanical Interface “Rail” Standard Electrical (Digital) Interface “Rail” Anyone’s Sensor Anyone’s Actuator SAM* Standard “hockey-puckPC” P V *Sensor/Actuator Manager Standard “connectivity ”

11. rnd/May 6, 200411 NeSSI™ an Enabling Technology for microAnalytical provides clear “standards” lowers infrastructure development costs and associated entry risk (faster to market) developer can concentrate on providing a premiere microAnalytical sensor – rather than infrastructure

12. rnd/May 6, 200412 Water “Cluster” Measurement Sensor Capsule Courtesy of Predictive Controls

13. rnd/May 6, 200413 Substrate On/Off and Modulating valves Flow Sensor w/ Temp, Pressure w/ Temp Substrate Moisture in Dry Gases PHASED * Micro GC Other Analytical: Ion, Nox. O 2, pH Conductivity, NOx, Turbidity, Density, Opacity Refractive Index, OthersChemometric Sensors for Complex Analytical Measurements. Mod Valve D/A Network Press/ Temp A/D Network *PHASED: Courtesy of Honeywell microGC

14. rnd/May 6, 200414 Conclusion NeSSI™ provides an enabling platform for microAnalytical microAnalytical will provide the greatest value and impact to End Users Just like John Harrison, finding the longitude in microAnalytical, is fast becoming a reality. Solution to longitude problem – a miniature, accurate, seaworthy timepiece. Courtesy of ©NMM London